Detalhe da pesquisa
1.
ZCCHC17 Modulates Neuronal RNA Splicing and Supports Cognitive Resilience in Alzheimer's Disease.
J Neurosci
; 44(3)2024 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38050142
2.
The Alzheimer's disease-associated C99 fragment of APP regulates cellular cholesterol trafficking.
EMBO J
; 39(20): e103791, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32865299
3.
Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate.
Proc Natl Acad Sci U S A
; 118(8)2021 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33542154
4.
RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.
Acta Neuropathol
; 145(1): 29-48, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36357715
5.
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.
Brain
; 145(7): 2486-2506, 2022 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35148384
6.
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9.
Nature
; 533(7601): 125-9, 2016 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27120160
7.
Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies.
Am J Physiol Cell Physiol
; 308(3): C209-19, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25394470
8.
A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease.
bioRxiv
; 2024 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38370689
9.
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons.
Cell Stem Cell
; 31(5): 676-693.e10, 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38626772
10.
Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein.
J Biol Chem
; 287(3): 2247-56, 2012 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22128169
11.
ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease.
bioRxiv
; 2023 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36993746
12.
Aß42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy.
Nat Commun
; 13(1): 4444, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35915085
13.
Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer's disease.
Front Cell Dev Biol
; 10: 926914, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36092705
14.
Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics.
Cell Death Dis
; 13(11): 959, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36379916
15.
Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors.
Curr Protoc
; 1(6): e141, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34102035
16.
Alzheimer's disease and the autophagic-lysosomal system.
Neurosci Lett
; 697: 49-58, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29758300
17.
Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer's Disease iPSC-Derived Neural Stem Cells.
Mol Neurobiol
; 56(12): 8220-8236, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31203573
18.
CRISPR/Cas9 editing of APP C-terminus attenuates ß-cleavage and promotes α-cleavage.
Nat Commun
; 10(1): 53, 2019 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30604771
19.
Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation.
Front Mol Neurosci
; 10: 291, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28959184
20.
CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons.
Acta Neuropathol Commun
; 5(1): 77, 2017 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29078805