Detalhe da pesquisa
1.
Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides.
Bioconjug Chem
; 33(8): 1441-1445, 2022 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35894801
2.
Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.
Bioorg Med Chem Lett
; 30(11): 127163, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32273214
3.
Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2.
J Med Chem
; 66(14): 9881-9893, 2023 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37433017
4.
Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.
Nat Commun
; 14(1): 3583, 2023 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37328472
5.
Effective 1,5-, 1,6- and 1,7-remote stereocontrol in reactions of alkoxy- and hydroxy-substituted allylstannanes with aldehydes.
Org Biomol Chem
; 9(10): 3896-919, 2011 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21472165
6.
Influence of Lipophilicity on the Antibacterial Activity of Polymyxin Derivatives and on Their Ability to Act as Potentiators of Rifampicin.
ACS Infect Dis
; 7(4): 894-905, 2021 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33688718
7.
Diels-Alder exo selectivity in terminal-substituted dienes and dienophiles: experimental discoveries and computational explanations.
J Am Chem Soc
; 131(5): 1947-57, 2009 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19154113
8.
Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206.
ACS Infect Dis
; 5(10): 1645-1656, 2019 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31525992
9.
BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.
Bioorg Med Chem Lett
; 18(3): 1017-21, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18166458
10.
BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).
Bioorg Med Chem Lett
; 18(3): 1011-6, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18171614
11.
BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.
Bioorg Med Chem Lett
; 18(3): 1022-6, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18171615
12.
The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor.
Bioorg Med Chem Lett
; 18(24): 6429-36, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19006669
13.
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A.
J Med Chem
; 60(3): 1000-1017, 2017 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28075591
14.
3-Hydroxypyrrolidines from epoxysulfonamides and dimethylsulfoxonium methylide.
Chem Commun (Camb)
; (30): 3226-8, 2006 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17028751
15.
One-carbon homologation of N-sulfonylaziridines to allylic amines using dimethylsulfonium methylide.
Org Lett
; 7(15): 3295-8, 2005 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16018644
16.
Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate.
J Med Chem
; 52(4): 1180-9, 2009 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19191554
17.
The reactivity of epoxides with lithium 2,2,6,6-tetramethylpiperidide in combination with organolithiums or grignard reagents.
J Org Chem
; 72(13): 4763-73, 2007 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17530802
18.
Alkenes from terminal epoxides using lithium 2,2,6,6-tetramethylpiperidide and organolithiums or grignard reagents.
J Am Chem Soc
; 126(39): 12250-1, 2004 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15453742
19.
The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.
Bioorg Med Chem Lett
; 13(6): 1067-70, 2003 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12643913
20.
Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones.
Bioorg Med Chem Lett
; 12(1): 51-5, 2002 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-11738571