Detalhe da pesquisa
1.
Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides.
Bioconjug Chem
; 33(8): 1441-1445, 2022 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35894801
2.
Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2.
J Med Chem
; 66(14): 9881-9893, 2023 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37433017
3.
Effective 1,5-, 1,6- and 1,7-remote stereocontrol in reactions of alkoxy- and hydroxy-substituted allylstannanes with aldehydes.
Org Biomol Chem
; 9(10): 3896-919, 2011 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21472165
4.
Diels-Alder exo selectivity in terminal-substituted dienes and dienophiles: experimental discoveries and computational explanations.
J Am Chem Soc
; 131(5): 1947-57, 2009 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19154113
5.
The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor.
Bioorg Med Chem Lett
; 18(24): 6429-36, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19006669
6.
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A.
J Med Chem
; 60(3): 1000-1017, 2017 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28075591
7.
3-Hydroxypyrrolidines from epoxysulfonamides and dimethylsulfoxonium methylide.
Chem Commun (Camb)
; (30): 3226-8, 2006 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17028751
8.
One-carbon homologation of N-sulfonylaziridines to allylic amines using dimethylsulfonium methylide.
Org Lett
; 7(15): 3295-8, 2005 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16018644
9.
Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate.
J Med Chem
; 52(4): 1180-9, 2009 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19191554
10.
The reactivity of epoxides with lithium 2,2,6,6-tetramethylpiperidide in combination with organolithiums or grignard reagents.
J Org Chem
; 72(13): 4763-73, 2007 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17530802
11.
Alkenes from terminal epoxides using lithium 2,2,6,6-tetramethylpiperidide and organolithiums or grignard reagents.
J Am Chem Soc
; 126(39): 12250-1, 2004 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15453742
12.
The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.
Bioorg Med Chem Lett
; 13(6): 1067-70, 2003 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12643913
13.
Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones.
Bioorg Med Chem Lett
; 12(1): 51-5, 2002 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-11738571
14.
The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man.
Bioorg Med Chem Lett
; 12(18): 2603-6, 2002 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-12182870