Detalhe da pesquisa
1.
Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition.
Proc Natl Acad Sci U S A
; 119(27): e2200260119, 2022 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35771941
2.
Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
Bioorg Med Chem
; 28(21): 115738, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33065433
3.
Identification of azabenzimidazoles as potent JAK1 selective inhibitors.
Bioorg Med Chem Lett
; 26(1): 60-7, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26614408
4.
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Bioorg Med Chem
; 24(18): 4008-4015, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27377864
5.
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.
Proc Natl Acad Sci U S A
; 108(37): 15366-71, 2011 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21896751
6.
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition.
Bioorg Med Chem Lett
; 22(17): 5563-8, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22858142
7.
Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors.
Nat Commun
; 13(1): 6447, 2022 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36307407
8.
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.
J Med Chem
; 65(14): 9819-9845, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35816678
9.
The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis.
Biochemistry
; 49(37): 7972-4, 2010 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20726546
10.
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
Bioorg Med Chem
; 18(21): 7486-96, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20869876
11.
Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction.
ACS Med Chem Lett
; 11(5): 740-746, 2020 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32435379
12.
Design of selective Cathepsin inhibitors.
Bioorg Med Chem Lett
; 19(16): 4622-5, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19616430
13.
Dipeptidyl nitrile inhibitors of Cathepsin L.
Bioorg Med Chem Lett
; 19(15): 4280-3, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19515558
14.
Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability.
J Med Chem
; 62(15): 7032-7041, 2019 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31283222
15.
Molecular Insights into Function and Competitive Inhibition of Pseudomonas aeruginosa Multiple Virulence Factor Regulator.
mBio
; 9(1)2018 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29339431
16.
Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau.
Acta Neuropathol Commun
; 6(1): 59, 2018 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30001207
17.
Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
J Med Chem
; 61(3): 989-1000, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29227683
18.
Discovery of a Potent, Orally Bioavailable PI4KIIIß Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.
J Med Chem
; 61(15): 6705-6723, 2018 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29952567
19.
A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun
; 6(1): 43, 2018 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29855358
20.
Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.
J Med Chem
; 60(8): 3511-3517, 2017 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28300404