Detalhe da pesquisa
1.
Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo.
Nucleic Acids Res
; 51(20): 11258-11276, 2023 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37791873
2.
Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling.
EMBO Rep
; 22(5): e51740, 2021 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33738926
3.
Altered calcium dynamics and glutamate receptor properties in iPSC-derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations.
Hum Mol Genet
; 28(17): 2835-2850, 2019 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31108504
4.
Investigating human disease using stem cell models.
Nat Rev Genet
; 15(9): 625-39, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25069490
5.
Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors.
Proc Natl Acad Sci U S A
; 114(11): E2243-E2252, 2017 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28246330
6.
Genome Wide Analysis Points towards Subtype-Specific Diseases in Different Genetic Forms of Amyotrophic Lateral Sclerosis.
Int J Mol Sci
; 21(18)2020 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32967368
7.
Human Spinal Motor Neurons Are Particularly Vulnerable to Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients.
Int J Mol Sci
; 21(10)2020 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32443559
8.
Combined Dendritic and Axonal Deterioration Are Responsible for Motoneuronopathy in Patient-Derived Neuronal Cell Models of Chorea-Acanthocytosis.
Int J Mol Sci
; 21(5)2020 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32151030
9.
FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy.
Acta Neuropathol
; 138(1): 67-84, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30937520
10.
Defective mitochondrial and lysosomal trafficking in chorea-acanthocytosis is independent of Src-kinase signaling.
Mol Cell Neurosci
; 92: 137-148, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30081151
11.
Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß.
Angew Chem Int Ed Engl
; 58(46): 16617-16628, 2019 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31454140
12.
Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization.
J Neurosci
; 36(47): 12027-12043, 2016 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27881786
13.
4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from Amyotrophic Lateral Sclerosis Patient-Derived Induced Pluripotent Stem Cells.
Stem Cells
; 34(6): 1563-75, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26946488
14.
Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction.
Angew Chem Int Ed Engl
; 56(42): 13021-13025, 2017 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28833911
15.
Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway.
Hum Mol Genet
; 23(8): 2005-22, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24271013
16.
Stepwise acquirement of hallmark neuropathology in FUS-ALS iPSC models depends on mutation type and neuronal aging.
Neurobiol Dis
; 82: 420-429, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26253605
17.
MAPT Mutations V337M and N297K Alter Organelle Trafficking in Frontotemporal Dementia Patient-Specific Motor Neurons.
Biomedicines
; 12(3)2024 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38540253
18.
Glycolic acid and D-lactate-putative products of DJ-1-restore neurodegeneration in FUS - and SOD1-ALS.
Life Sci Alliance
; 7(8)2024 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-38760174
19.
Axonal Lysosomal Assays for Characterizing the Effects of LRRK2 G2019S.
Biology (Basel)
; 13(1)2024 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38275734
20.
Targeting low levels of MIF expression as a potential therapeutic strategy for ALS.
Cell Rep Med
; : 101546, 2024 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38703766