RESUMO
The interplay between mycobacteria and host determines the outcome of infection. After uptake of mycobacteria by macrophages, several possible scenarios may emerge; mycobacteria may be destroyed immediately or there is establishment of persistent infection. This review is focused around mycobacteria-host interactions with reference to Mycobacterium avium subspecies paratuberculosis (MAP) infection and highlights protective mechanisms involved in order to design vaccines and other control strategies.
Assuntos
Citocinas/metabolismo , Macrófagos/imunologia , Mycobacterium avium subsp. paratuberculosis/imunologia , Paratuberculose/imunologia , Receptores Toll-Like/imunologia , Animais , Anticorpos Antibacterianos/biossíntese , Linfócitos T CD4-Positivos/imunologia , Citocinas/imunologia , Citotoxicidade Imunológica , Células Dendríticas/imunologia , Humanos , Macrófagos/microbiologia , Mycobacterium avium subsp. paratuberculosis/patogenicidade , Paratuberculose/microbiologia , Fagocitose , Receptores de Antígenos de Linfócitos T gama-delta/imunologia , Receptores de Antígenos de Linfócitos T gama-delta/metabolismo , Receptores Toll-Like/metabolismoRESUMO
Mycobacterium avium subspecies paratuberculosis (MAP) is the etiological agent of paratuberculosis, a chronic gastroenteritis of ruminants and has zoonotic importance. We present here a review of MAP with respect to--(i) present diagnostic techniques and important developments; and (ii) MAP strain-typing tools. A summary of the findings to date is presented, and advantages and disadvantages of each of the methods are compared and discussed.