Detalhe da pesquisa
1.
Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain.
Bioorg Med Chem Lett
; 28(23-24): 3780-3783, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30337231
2.
Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes.
Bioorg Med Chem Lett
; 28(5): 841-846, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456108
3.
Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists.
Bioorg Med Chem Lett
; 27(8): 1760-1764, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28285911
4.
Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists.
Bioorg Med Chem Lett
; 27(15): 3272-3278, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28642104
5.
Discovery and SAR of 5-aminooctahydrocyclopentapyrrole-3a-carboxamides as potent CCR2 antagonists.
Bioorg Med Chem Lett
; 24(4): 1239-42, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23916257
6.
The discovery and SAR of cyclopenta[b]furans as inhibitors of CCR2.
Bioorg Med Chem Lett
; 24(9): 2137-40, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24685539
7.
Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel.
Bioorg Med Chem Lett
; 24(9): 2053-6, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24726802
8.
Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors.
Bioorg Med Chem Lett
; 24(9): 2057-61, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24726803
9.
A novel series of N-(azetidin-3-yl)-2-(heteroarylamino)acetamide CCR2 antagonists.
Bioorg Med Chem Lett
; 23(4): 1063-9, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23294701
10.
Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists.
Bioorg Med Chem Lett
; 23(1): 351-4, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23182090
11.
Erratum to "Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes" Bioorg. Med. Chem. Lett. 28 (2018) [841-846].
Bioorg Med Chem Lett
; 28(9): 1676-1678, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29605534
12.
A novel series of pyrazolylpiperidine N-type calcium channel blockers.
Bioorg Med Chem Lett
; 22(12): 4080-3, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22608964
13.
Effect of Interfacial Lubrication between Rubber and Metal on Reducing Mixer Chamber Wall Wear in Mixing Process.
Polymers (Basel)
; 14(17)2022 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36080556
14.
Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads.
J Med Chem
; 65(6): 4600-4615, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35293760
15.
Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors.
Bioorg Med Chem Lett
; 21(16): 4762-7, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21767952
16.
Design, synthesis and SAR of indazole and benzoisoxazole containing 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists.
Bioorg Med Chem Lett
; 21(20): 6042-8, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21917454
17.
Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists.
Bioorg Med Chem Lett
; 21(18): 5577-82, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21783361
18.
The discovery of novel cyclohexylamide CCR2 antagonists.
Bioorg Med Chem Lett
; 21(24): 7496-501, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22061641
19.
Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J Med Chem
; 64(8): 4430-4449, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33829783
20.
MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage.
Cancer Cell
; 39(2): 209-224.e11, 2021 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33450196