RESUMO
We report the case of a Caucasian 73-year-old woman, without medical history, who is operated of two lesions of the forehead and the scalp measuring 0.4 and 1cm. There is no adenopathy. Histopathological examination revealed a diffuse vascular proliferation of the dermis and the hypodermis composed of small vessels bordered of plump "epthelioid" endothelial cells. There is no mitotic figure. The stroma is slightly fibrous accompanied by a polymorphic inflammatory infiltrate rich in lymphocytes, sometimes arranged in lymphoid follicles, plasma cells and eosinophils. The proposed diagnosis is angiolymphoid hyperplasia with eosinophilia. This is a rare vascular tumor, benign according with the OMS classification and preferentially observed in the skin. We report a cutaneous case, clinical and histopathological data of the reported cases and present the main differential diagnoses.
Assuntos
Hiperplasia Angiolinfoide com Eosinofilia/patologia , Neoplasias de Cabeça e Pescoço/patologia , Hemangioma/patologia , Couro Cabeludo/patologia , Neoplasias Cutâneas/patologia , Idoso , Hiperplasia Angiolinfoide com Eosinofilia/diagnóstico , Hiperplasia Angiolinfoide com Eosinofilia/epidemiologia , Angiomatose Bacilar/diagnóstico , Diagnóstico Diferencial , Neoplasias Faciais/diagnóstico , Neoplasias Faciais/patologia , Feminino , Testa , Neoplasias de Cabeça e Pescoço/diagnóstico , Hemangioma/diagnóstico , Hemangioma/epidemiologia , Humanos , Inflamação , Linfócitos/patologia , Linfoma não Hodgkin/diagnóstico , Plasmócitos/patologia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/epidemiologiaAssuntos
Neoplasias da Mama , Lipoma , Mama , Neoplasias da Mama/cirurgia , Feminino , Humanos , Lipoma/diagnósticoRESUMO
We report the case of a 57-year-old man, who is hospitalized for the surgery of a gallbladder mass associated by an increase in fluorodeoxyglucose-activity on positron emission tomography/computed tomography scan. This is an incidental finding occurring during monitoring of a skin melanoma. A cholecystectomy is performed. Microscopic examination identified an infiltration of the gallbladder wall by a proliferation of atypical pigmented spindled melanocytes with numerous mitoses. The immunohistochemical analysis confirmed the melanocytic nature of this proliferation with the staining of HMB-45, S100 protein and Melan-A. A complementary immunohistochemical (p16, desmin and BRAFV600E) and molecular (BRAF sequencing) study is performed. The results are consistent with the hypothesis of a gallbladder metastasis of a cutaneous melanoma is proposed. Gallbladder metastases of melanoma are exceptional. The aim of our work is to describe a new case with immunohistochemical and molecular characterization, to review the literature on this topic and to consider the main differential diagnosis (primary malignant melanoma of the gallbladder).
Assuntos
Neoplasias da Vesícula Biliar/secundário , Melanoma/secundário , Biomarcadores Tumorais/análise , Colecistectomia , Neoplasias da Vesícula Biliar/química , Neoplasias da Vesícula Biliar/diagnóstico por imagem , Neoplasias da Vesícula Biliar/cirurgia , Humanos , Achados Incidentais , Masculino , Melanoma/química , Melanoma/patologia , Melanoma/cirurgia , Pessoa de Meia-Idade , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Neoplasias Cutâneas/patologiaAssuntos
Carcinoma de Célula de Merkel/diagnóstico , Diagnóstico Diferencial , Biomarcadores Tumorais , Carcinoma de Célula de Merkel/patologia , Humanos , Imuno-Histoquímica , Masculino , Poliomavírus das Células de Merkel/isolamento & purificação , Pessoa de Meia-Idade , Metástase Neoplásica , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/patologia , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/patologia , Neoplasias Gástricas/secundárioRESUMO
We report the case of a 52-year-old man, who was admitted in the department of otorhinolaryngology for a mass of the right parotid gland. The radiological and clinical hypothesis was a squamous cell carcinoma. Histopathological examination revealed a biphasic proliferation composed of epithelial cells arranged in a tubular pattern stained with cytokeratins 5-6 and 7 and EMA surrounded by clear myoepithelial cells stained with smooth muscle actin and p63. Ki-67 labeling index was low. The diagnosis of epithelial myoepithelial carcinoma was proposed. One year after, the patient noticed a centimetric mass of the left parotid gland. The radiological hypothesis was the presence of an intraparotidian lymph node. Histopathological examination showed a second epithelial myoepithelial carcinoma. This is an uncommon neoplasm comprising approximately 1% of all salivary gland tumours, affecting mainly the parotid gland. It is occurring preferably in patients older than 60years old. This is a low-grade malignant tumour with tendency to local recurrence and lymph node metastatic potential. We describe an exceptional bilateral epithelial myoepithelial carcinoma of the parotid gland.