Detalhe da pesquisa
1.
The MYPT2-regulated striated muscle-specific myosin light chain phosphatase limits cardiac myosin phosphorylation in vivo.
J Biol Chem
; 300(2): 105652, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38224947
2.
Molecular basis of force-pCa relation in MYL2 cardiomyopathy mice: Role of the super-relaxed state of myosin.
Proc Natl Acad Sci U S A
; 119(8)2022 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35177471
3.
Hydroxychloroquine Mitigates Dilated Cardiomyopathy Phenotype in Transgenic D94A Mice.
Int J Mol Sci
; 23(24)2022 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36555229
4.
Mavacamten decreases maximal force and Ca2+ sensitivity in the N47K-myosin regulatory light chain mouse model of hypertrophic cardiomyopathy.
Am J Physiol Heart Circ Physiol
; 320(2): H881-H890, 2021 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33337957
5.
Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice.
Proc Natl Acad Sci U S A
; 115(10): E2338-E2347, 2018 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29463717
6.
Allele-Specific Silencing Ameliorates Restrictive Cardiomyopathy Attributable to a Human Myosin Regulatory Light Chain Mutation.
Circulation
; 140(9): 765-778, 2019 08 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31315475
7.
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.
FASEB J
; 33(3): 3152-3166, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30365366
8.
Insights into myosin regulatory and essential light chains: a focus on their roles in cardiac and skeletal muscle function, development and disease.
J Muscle Res Cell Motil
; 41(4): 313-327, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31131433
9.
Genomic Amplification and Functional Dependency of the Gamma Actin Gene ACTG1 in Uterine Cancer.
Int J Mol Sci
; 21(22)2020 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33217970
10.
Hereditary heart disease: pathophysiology, clinical presentation, and animal models of HCM, RCM, and DCM associated with mutations in cardiac myosin light chains.
Pflugers Arch
; 471(5): 683-699, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30706179
11.
Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.
Proc Natl Acad Sci U S A
; 112(30): E4138-46, 2015 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26124132
12.
N-Terminus of Cardiac Myosin Essential Light Chain Modulates Myosin Step-Size.
Biochemistry
; 55(1): 186-98, 2016 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26671638
13.
Gene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain.
Arch Biochem Biophys
; 601: 121-32, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26906074
14.
Myosin regulatory light chain phosphorylation enhances cardiac ß-myosin in vitro motility under load.
Arch Biochem Biophys
; 580: 14-21, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26116789
15.
Molecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutations.
J Muscle Res Cell Motil
; 36(6): 433-45, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26385864
16.
Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains.
J Muscle Res Cell Motil
; 36(6): 447-61, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26668058
17.
Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.
J Mol Cell Cardiol
; 74: 318-29, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24992035
18.
In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain.
Arch Biochem Biophys
; 552-553: 29-39, 2014 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24374283
19.
Mechanistic basis for rescuing hypertrophic cardiomyopathy with myosin regulatory light chain phosphorylation.
Cytoskeleton (Hoboken)
; 2024 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38494592
20.
Diversity and similarity of motor function and cross-bridge kinetics in papillary muscles of transgenic mice carrying myosin regulatory light chain mutations D166V and R58Q.
J Mol Cell Cardiol
; 62: 153-63, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23727233