Detalhe da pesquisa
1.
Distinctive sphingolipid patterns in chronic multiple sclerosis lesions.
J Lipid Res
; 61(11): 1464-1479, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32769146
2.
Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis.
J Biol Chem
; 294(2): 502-519, 2019 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30420430
3.
Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis.
Cytokine
; 135: 155219, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32738771
4.
The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction.
FASEB J
; 33(6): 7647-7666, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30917007
5.
Mechanistic insights into ceramidase inhibitor LCL521-enhanced tumor cell killing by photodynamic and thermal ablation therapies.
Photochem Photobiol Sci
; 19(9): 1145-1151, 2020 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32821888
6.
Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML.
Blood
; 128(15): 1944-1958, 2016 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27540013
7.
Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.
Prostaglandins Other Lipid Mediat
; 130: 47-56, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28377281
8.
Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line.
J Lipid Res
; 57(11): 2028-2039, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27623848
9.
Interaction of acid ceramidase inhibitor LCL521 with tumor response to photodynamic therapy and photodynamic therapy-generated vaccine.
Int J Cancer
; 139(6): 1372-8, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27136745
10.
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
Nat Chem Biol
; 8(10): 831-8, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22922758
11.
Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.
Bioorg Med Chem
; 22(24): 6933-44, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25456083
12.
Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors.
iScience
; 27(6): 109860, 2024 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38779482
13.
2'-hydroxy C16-ceramide induces apoptosis-associated proteomic changes in C6 glioma cells.
J Proteome Res
; 12(10): 4366-75, 2013 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23987666
14.
Ceramide channels: influence of molecular structure on channel formation in membranes.
Biochim Biophys Acta
; 1818(5): 1291-301, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22365970
15.
LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria.
J Pharmacol Exp Ther
; 344(1): 167-78, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23086228
16.
Bax and Bcl-xL exert their regulation on different sites of the ceramide channel.
Biochem J
; 445(1): 81-91, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22494048
17.
Ceramide is implicated in humoral peripheral and intrathecal autoimmune response in MS patients.
Mult Scler Relat Disord
; 71: 104565, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36821978
18.
Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects.
Aging Cell
; 22(10): e13954, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37614052
19.
Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia.
bioRxiv
; 2023 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37961314
20.
Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia.
Cancers (Basel)
; 15(24)2023 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38136410