Detalhe da pesquisa
1.
Bioactivation and reactivity research advances - 2022 year in review.
Drug Metab Rev
; 55(4): 267-300, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37608698
2.
Biotransformation research advances - 2022 year in review.
Drug Metab Rev
; 55(4): 301-342, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37737116
3.
The Absolute Bioavailability and Absorption, Metabolism, and Excretion of Ipatasertib, a Potent and Highly Selective Protein Kinase B (Akt) Inhibitor.
Drug Metab Dispos
; 51(10): 1332-1341, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37524543
4.
Characterization of Hepatic UDP-Glucuronosyltransferase Enzyme Abundance-Activity Correlations and Population Variability Using a Proteomics Approach and Comparison with Cytochrome P450 Enzymes.
Drug Metab Dispos
; 49(9): 760-769, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34187837
5.
Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate.
Drug Metab Dispos
; 48(2): 86-92, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31757797
6.
Novel Homodimer Metabolites of GDC-0994 via Cytochrome P450-Catalyzed Radical Coupling.
Drug Metab Dispos
; 48(6): 521-527, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32234735
7.
Regional Proteomic Quantification of Clinically Relevant Non-Cytochrome P450 Enzymes along the Human Small Intestine.
Drug Metab Dispos
; 48(7): 528-536, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32350063
8.
Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human.
Mol Pharm
; 17(11): 4114-4124, 2020 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32955894
9.
Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species.
Anal Biochem
; 556: 85-90, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29959909
10.
Applying Stable Isotope Labeled Amino Acids in Micropatterned Hepatocyte Coculture to Directly Determine the Degradation Rate Constant for CYP3A4.
Drug Metab Dispos
; 45(6): 581-585, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28289057
11.
CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339.
Drug Metab Dispos
; 45(10): 1084-1092, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28790146
12.
Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450.
Drug Metab Dispos
; 45(5): 430-440, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28188299
13.
Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions.
Mol Pharm
; 14(5): 1754-1759, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28345929
14.
Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs.
Xenobiotica
; 47(1): 50-65, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27055783
15.
Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans.
Drug Metab Dispos
; 44(1): 28-39, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26451002
16.
Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450-Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor.
Drug Metab Dispos
; 43(12): 1929-33, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26438627
17.
Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases.
J Med Chem
; 67(7): 5758-5782, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38511649
18.
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
J Med Chem
; 65(24): 16290-16312, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36469401
19.
Coexpression of Human Hepatic Uridine Diphosphate Glucuronosyltransferase Proteins: Implications for Ontogenetic Mechanisms and Isoform Coregulation.
J Clin Pharmacol
; 60(6): 722-733, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31879975
20.
The effect of allelic variation in aldo-keto reductase 1C2 on the in vitro metabolism of dihydrotestosterone.
J Pharmacol Exp Ther
; 329(3): 1032-9, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19258517