1.
Chemistry
; 20(29): 8893-7, 2014 Jul 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24938426
RESUMO
A highly chemo-, enantio-, and regioselective synthesis of furanones bearing an α,α-disubstituted quaternary stereogenic center is reported. The Cu-catalyzed enantioselective conjugate addition of organoaluminum reagents to unsaturated ketoesters at room temperature and subsequent lactonization took place. Synthetic transformations of furanones represent facile approaches to various cyclic or acyclic compounds bearing a quaternary stereogenic center.