Detalhe da pesquisa
1.
GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease.
Gastroenterology
; 155(5): 1463-1473.e6, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30059671
2.
Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis.
Clin Gastroenterol Hepatol
; 16(12): 1983-1991.e3, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29705265
3.
Proof of Concept for an Automated Image Analysis Method to Quantify Rat Bone Marrow Hematopoietic Lineages on H&E Sections.
Toxicol Pathol
; 46(3): 336-347, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29683092
4.
Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats.
J Pharmacol Exp Ther
; 360(1): 226-238, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27821712
5.
MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats.
Toxicol Pathol
; 45(2): 353-361, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27565173
6.
Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid.
Toxicol Mech Methods
; 25(3): 201-11, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25894564
7.
Development of a safety biomarker signature to detect hepatic sinusoidal dilation associated with an anti-DLL4 biotherapeutic.
Biomarkers
; 19(5): 391-401, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24842386
8.
Unexpected hematologic effects of biotherapeutics in nonclinical species and in humans.
Toxicol Pathol
; 41(2): 280-302, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23471185
9.
Current practices in preclinical drug development: gaps in hemostasis testing to assess risk of thromboembolic injury.
Toxicol Pathol
; 41(3): 445-53, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-22991386
10.
A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity.
J Immunol
; 185(6): 3158-66, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20709950
11.
Filgotinib, a JAK1 Inhibitor, Modulates Disease-Related Biomarkers in Rheumatoid Arthritis: Results from Two Randomized, Controlled Phase 2b Trials.
Rheumatol Ther
; 7(1): 173-190, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31912462
12.
Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer.
PLoS One
; 13(6): e0198099, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29879147
13.
The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses.
Mol Cell Biol
; 22(14): 5006-18, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12077330
14.
Therapeutic Antibody-Induced Vascular Toxicity Due to Off-Target Activation of Nitric Oxide in Cynomolgus Monkeys.
Toxicol Sci
; 151(2): 245-60, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26917699
15.
The role of flow cytometry in companion animal diagnostic medicine.
Vet J
; 170(3): 278-88, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16266842
16.
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.
Sci Transl Med
; 7(279): 279ra40, 2015 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25787766
17.
Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier.
Sci Transl Med
; 5(183): 183ra57, 1-12, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23636093
18.
Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.
Toxicol Sci
; 125(1): 187-95, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21976371
19.
Blood cytokines as biomarkers of in vivo toxicity in preclinical safety assessment: considerations for their use.
Toxicol Sci
; 117(1): 4-16, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20447938
20.
Overestimation of canine albumin concentration with the bromcresol green method in heparinized plasma samples.
Vet Clin Pathol
; 30(4): 170-176, 2001.
Artigo
em Inglês
| MEDLINE | ID: mdl-12024297