Detalhe da pesquisa
1.
Alpha-hydroxytropolones are noncompetitive inhibitors of human RNase H1 that bind to the active site and modulate substrate binding.
J Biol Chem
; 298(4): 101790, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35247386
2.
Effects of Troponoids on Mitochondrial Function and Cytotoxicity.
Antimicrob Agents Chemother
; 66(1): e0161721, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34694883
3.
Synthesis of Polyoxygenated Tropolones and their Antiviral Activity against Hepatitis B Virus and Herpes Simplex Virus-1.
Chemistry
; 28(10): e202104112, 2022 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34984767
4.
Design, synthesis, and biological evaluation of novel sulfamoylbenzamide derivatives as HBV capsid assembly modulators.
Bioorg Chem
; 129: 106192, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36265355
5.
Efficient Inhibition of Hepatitis B Virus (HBV) Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors during Infection.
Antimicrob Agents Chemother
; 65(12): e0146021, 2021 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34516242
6.
Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV.
Virol J
; 17(1): 140, 2020 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32948191
7.
Endonuclease Activity Inhibition of the NS1 Protein of Parvovirus B19 as a Novel Target for Antiviral Drug Development.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30530599
8.
Synergistic Interactions between Hepatitis B Virus RNase H Antagonists and Other Inhibitors.
Antimicrob Agents Chemother
; 61(3)2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27956427
9.
Troponoids Can Inhibit Growth of the Human Fungal Pathogen Cryptococcus neoformans.
Antimicrob Agents Chemother
; 61(4)2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28167553
10.
Biographical Feature: William S. M. Wold, Ph.D., 1944-2021.
J Virol
; 95(22): e0118421, 2021 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34549981
11.
Synthetic α-Hydroxytropolones Inhibit Replication of Wild-Type and Acyclovir-Resistant Herpes Simplex Viruses.
Antimicrob Agents Chemother
; 60(4): 2140-9, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26787704
12.
Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.
Antimicrob Agents Chemother
; 59(2): 1070-9, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25451058
13.
Comparative analysis of hepatitis B virus polymerase sequences required for viral RNA binding, RNA packaging, and protein priming.
J Virol
; 88(3): 1564-72, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24227865
14.
The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes.
PLoS Pathog
; 9(1): e1003125, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23349632
15.
Inhibitors of nucleotidyltransferase superfamily enzymes suppress herpes simplex virus replication.
Antimicrob Agents Chemother
; 58(12): 7451-61, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25267681
16.
NVR 3-778 Plus Pegylated Interferon-α Treatment for Chronic Hepatitis B Viral Infections: Could 1 + 1 = 3?
Gastroenterology
; 154(3): 481-482, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29337155
17.
Sexual transmission of hepatitis C virus among monogamous heterosexual couples: the HCV partners study.
Hepatology
; 57(3): 881-9, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23175457
18.
Host factor-targeted hepatitis B virus therapies.
Intervirology
; 57(3-4): 158-62, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25034483
19.
Hepatitis C virus envelope glycoprotein signatures are associated with treatment failure and modulation of viral entry and neutralization.
J Infect Dis
; 207(8): 1306-15, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23335805
20.
Identification and assessment of the 1,6-dihydroxy-pyridin-2-one moiety as privileged scaffold for HBV ribonuclease H inhibition.
Antiviral Res
; 223: 105833, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38325606