Detalhe da pesquisa
1.
A single post-exposure oxime RS194B treatment rapidly reactivates acetylcholinesterase and reverses acute symptoms in macaques exposed to diethylphosphorothioate parathion and chlorpyrifos insecticides.
J Neurochem
; 168(4): 370-380, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-36786545
2.
Cholinergic Capsules and Academic Admonitions.
Annu Rev Pharmacol Toxicol
; 61: 25-46, 2021 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33411578
3.
The Cyclic Imine Core Common to the Marine Macrocyclic Toxins Is Sufficient to Dictate Nicotinic Acetylcholine Receptor Antagonism.
Mar Drugs
; 22(4)2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38667766
4.
Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects.
J Biol Chem
; 297(3): 101007, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34324828
5.
Differential Activation and Desensitization States Promoted by Noncanonical α7 Nicotinic Acetylcholine Receptor Agonists.
J Pharmacol Exp Ther
; 383(2): 157-171, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36279397
6.
Interactions of Nereistoxin and Its Analogs with Vertebrate Nicotinic Acetylcholine Receptors and Molluscan ACh Binding Proteins.
Mar Drugs
; 20(1)2022 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35049904
7.
Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase.
J Biol Chem
; 295(13): 4079-4092, 2020 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32019865
8.
Ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical.
J Neurochem
; 158(6): 1217-1222, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33638151
9.
Enhancing Target Tissue Levels and Diminishing Plasma Clearance of Ionizing Zwitterionic Antidotes in Organophosphate Exposures.
J Pharmacol Exp Ther
; 378(3): 315-321, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34145064
10.
Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase.
J Biol Chem
; 294(27): 10607-10618, 2019 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31138650
11.
Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.
Toxicol Appl Pharmacol
; 372: 40-46, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30978400
12.
Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase.
Chemistry
; 25(16): 4100-4114, 2019 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30458057
13.
Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure.
J Pharmacol Exp Ther
; 367(2): 363-372, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30190337
14.
Planarian cholinesterase: molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity.
Arch Toxicol
; 92(3): 1161-1176, 2018 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-29167930
15.
Substituted 2-Aminopyrimidines Selective for α7-Nicotinic Acetylcholine Receptor Activation and Association with Acetylcholine Binding Proteins.
J Am Chem Soc
; 139(10): 3676-3684, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28221788
16.
Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors.
J Neurochem
; 142 Suppl 2: 41-51, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28326551
17.
Butyrylcholinesterase identification in a phenylvalerate esterase-enriched fraction sensitive to low mipafox concentrations in chicken brain.
Arch Toxicol
; 91(2): 909-919, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26838044
18.
Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation.
Arch Toxicol
; 91(8): 2837-2847, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-27990564
19.
Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
Proc Natl Acad Sci U S A
; 111(29): 10749-54, 2014 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25006260
20.
Mechanisms of inhibition and potentiation of α4ß2 nicotinic acetylcholine receptors by members of the Ly6 protein family.
J Biol Chem
; 290(40): 24509-18, 2015 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26276394