αEß7 Expression Increases With the Extent of Cutaneous Involvement in Mycosis Fungoides.

BACKGROUND: Cell adhesion molecules are essential to lymphocyte migration in neoplastic and inflammatory skin diseases. Our aim was to investigate possible differences in cell adhesion molecule expression between mycosis fungoides (MF) and inflammatory skin diseases (drug reactions and allergic contact dermatitis). METHODS: We selected 33 biopsies from patients with MF and 10 biopsies of patients with inflammatory skin diseases from Department of Pathology-Universidade Federal de São Paulo (UNIFESP) from January 1997 to December 2013. Expression of α4ß1 integrin and αEß7 integrin was assessed by immunohistochemistry in intraepidermal lymphocytes by counting 4 microscopic epidermal fields (×400) and comparing those between the 2 groups. RESULTS: We observed increased expression of integrin αEß7 in intraepidermal lymphocytes in advanced stages of MF (T3 and T4). αEß7 expression was detected in intraepidermal dendritic cells of MF and inflammatory diseases samples. The expression of E-cadherin in epidermal cells in MF outlined Pautrier microabscesses, whereas in inflammatory diseases, spongiosis reduced its expression in keratinocytes. CONCLUSIONS: The findings presented here support the idea that the lymphocyte migratory mechanism observed in neoplasms is similar to that of inflammatory processes of the skin.

Dynamic ultrasound evaluation of body fillers and biostimulators in the buttocks of fresh-frozen specimen.

BACKGROUND: Ultrasound imaging is a useful tool to study the injection of fillers and biostimulators in the body. OBJECTIVE: Sonographically evaluate real-time injections of fillers and biostimulators and describe their behavior in the subcutaneous tissue of the buttocks of fresh-frozen specimen. METHODS: injection of two brands of high-density hyaluronic acid (HA), one brand of calcium hydroxyapatite (CaHA), one brand of hybrid injectable (CaHa + HA), one brand of polycaprolactone (PCL) and three brands of poly-l-lactic acid (PLLA) were performed in the subcutaneous tissue of the gluteal region under ultrasonography visualization on a fresh-frozen specimen. Videos during injection and static images immediately after injection were obtained. The sonographic aspects of the substances and their dispersion and interaction with the surrounding tissues were described. RESULTS: Real-time ultrasound showed different dispersion patterns of the two brands of HA, CaHA, hybrid injectable (CaHa + HA) and the three brands of PLLA. The sonographic aspects among the brands of PLLA were also different. CONCLUSIONS: The dynamic ultrasound evaluation of the injection of HA, CaHA, hybrid injectable (CaHa + HA), PCL and PLLA in a fresh-frozen specimen shed some light on their aspects and dispersion pattern in the buttock. If these patterns are confirmed in further studies in vivo, there will be a positive impact on the selection and development of safer and more effective techniques to enhance buttock contour.

Lenalidomide in the management of eosinophilic dermatosis of hematological malignancy.

Eosinophilic dermatosis of hematological malignancy is a paraneoplastic skin eruption associated with chronic lymphocytic leukemia and other B-cell malignancies. It clinically resembles an insect bite reaction and it can precede the symptoms of the hematological malignancy or be related to a more aggressive course. Different treatments have been proposed, but partial response and recurrence are frequent. Herein, we describe a case of eosinophilic dermatosis associated with mantle cell lymphoma with remission after lenalidomide therapy.

Tratamento não invasivo com ultrassom não focado transcutâneo na redução do tecido subcutâneo abdominal / Non-invasive treatment with transcutaneous non-focused ultrasound for the reduction of abdominal subcutaneous tissue

Introdução: O ultrassom não focado é alternativa não invasiva para melhora do contorno corporal. Métodos: São relatados cinco casos tratados com oito sessões semanais de ultrassom não focado no abdômen. Resultados: O tratamento não interferiu na rotina dos pacientes, tendo sido considerado confortável e seguro. Houve redução na espessura do subcutâneo avaliado por ultrassom e nas medidas circunferenciais em todos os pacientes, com melhora clínica evidenciada na documentação fotográfica principalmente nos pacientes com subcutâneo de baixa espessura. Conclusão: O tratamento se mostrou seguro, com evidências de redução do tecido subcutâneo abdominal.

Introduction: Introduction: Not focused ultrasound is a noninvasive alternative to improve body contour. Methods: It's reported five cases treated with eight weekly sessions of not focused ultrasound on the abdomen. Results: The treatment did not affect the routine of patients; it was comfortable and safe for most. There was a reduction in the thickness of the fat layer evaluated by ultrasound and in the circumferential measures in all patients, with clinical improvement evidenced in the photographic documentation especially in patients with lesser thickness of subcutaneous. Conclusion: The device was safe, and was shown clear reduction in abdominal subcutaneous tissue.

Limitations of DNA sequencing for diagnosis of a mixed infection by two fungi, Phaeoacremonium venezuelense and a Plectophomella sp., in a transplant recipient.

We describe a rare case of a subcutaneous infection by both Phaeoacremonium venezuelense and Plectophomella sp. in a Brazilian male. Sequencing of a beta-tubulin gene fragment allowed us to confirm the identification of the former. However, a similar procedure of sequencing rRNA gene fragments was not useful for the identification of the latter fungus.

Fotoproteção / Photoprotection

A radiação UV está associada ao desenvolvimento de alterações cutâneas agudas e crônicas, como queimadura, imunossupressão, alterações de pigmentação, fotoenvelhecimento e câncer de pele. A principal medida para minimizar os danos causados pelo UV é a fotoproteção. Muitos fatores afetam a transmissão UV na pele humana e a associação de medidas de fotoproteção física, uso adequado de filtros solares e suplementação com substâncias moduladoras e com atividade antirradical livre promove melhora significativa na prevenção dessas manifestações.

Maquiagem e camuflagem / x

O principal objetivo da Dermatologia é a prevenção e cura das doenças da pele, porém, nem sempre é possível atingir esse propósito, o que leva o paciente, muitas vezes, a ter de conviver com lesões inestéticas, deformantes.A camuflagem cosmética é uma modalidade terapêutica desenvolvida para diminuir o sofrimento de pacientes com lesões deformantes congênitas ou adquiridas, não acessíveis a tratamentos clínicos ou cirúrgicos, permitindo uma melhora na aparência.Estudos sobre o uso de camuflagem cosmética em pessoas com lesões desfigurantes mostram melhora significativa na qualidade de vida desses indivíduos.Atualmente, todos os dermatologistas deveriam estar familiarizados com os produtos de maquiagem corretiva para melhor ajudar seus pacientes com dermatoses desfigurantes.