Detalhe da pesquisa
1.
Design, synthesis, and optimization of a series of 2-azaspiro[3.3]heptane derivatives as orally bioavailable fetal hemoglobin inducers.
Bioorg Med Chem Lett
; 30(19): 127425, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32717372
2.
Analysis of signal transduction pathways involved in anti-CD30 mAb-induced human eosinophil apoptosis.
Int Arch Allergy Immunol
; 152 Suppl 1: 2-8, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20523057
3.
Phenotypic-screening generates active novel fetal globin-inducers that downregulate Bcl11a in a monkey model.
Biochem Pharmacol
; 171: 113717, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31751536
4.
Development of an exon skipping therapy for X-linked Alport syndrome with truncating variants in COL4A5.
Nat Commun
; 11(1): 2777, 2020 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32488001
5.
G protein-coupled receptor 39 plays an anti-inflammatory role by enhancing IL-10 production from macrophages under inflammatory conditions.
Eur J Pharmacol
; 834: 240-245, 2018 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30053407
6.
Heterogeneity of auto-antibodies against nAChR in myasthenic serum and their pathogenic roles in experimental autoimmune myasthenia gravis.
J Neuroimmunol
; 320: 64-75, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29759142
7.
Rapid and strong induction of apoptosis in human eosinophils by anti-CD30 mAb-coated microspheres and phagocytosis by macrophages.
Int Arch Allergy Immunol
; 143 Suppl 1: 60-7, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17541279
8.
Analysis of peripheral B cells and autoantibodies against the anti-nicotinic acetylcholine receptor derived from patients with myasthenia gravis using single-cell manipulation tools.
PLoS One
; 12(10): e0185976, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29040265
9.
Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils.
Eur J Pharmacol
; 538(1-3): 175-81, 2006 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16690053
10.
Design, synthesis, and biological evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2α inhibitors.
J Med Chem
; 57(17): 7244-62, 2014 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25102418
11.
Pharmacokinetic/pharmacodynamic analyses of chymase inhibitor SUN13834 in NC/Nga mice and prediction of effective dosage for atopic dermatitis patients.
Int Immunopharmacol
; 11(10): 1628-32, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21642018
12.
Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis.
Eur J Pharmacol
; 601(1-3): 186-91, 2008 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18996112
13.
CpG oligodeoxynucleotide prolongs eosinophil survival through activation of contaminating B cells and plasmacytoid dendritic cells in vitro.
Int Arch Allergy Immunol
; 140 Suppl 1: 42-50, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16772726
14.
Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway.
Biochem Biophys Res Commun
; 332(4): 969-75, 2005 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15919053
15.
NR4A orphan nuclear receptor family in peripheral blood eosinophils from patients with atopic dermatitis and apoptotic eosinophils in vitro.
Int Arch Allergy Immunol
; 137 Suppl 1: 35-44, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15947483
16.
Extremely rapid and intense induction of apoptosis in human eosinophils by anti-CD30 antibody treatment in vitro.
J Immunol
; 172(4): 2186-93, 2004 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14764685
17.
Oral administration of chymase inhibitor improves dermatitis in NC/Nga mice.
J Invest Dermatol
; 127(4): 971-3, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17255959