Detalhe da pesquisa
1.
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models.
Proc Natl Acad Sci U S A
; 120(1): e2211297120, 2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36574664
2.
Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors.
J Med Chem
; 66(24): 16783-16806, 2023 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38085679
3.
Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization.
J Med Chem
; 65(8): 6287-6312, 2022 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35436124
4.
Discovery of 1-Benzoyl 4-Phenoxypiperidines as Small-Molecule Inhibitors of the ß-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.
J Med Chem
; 64(15): 11195-11218, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34270257
5.
Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3).
J Med Chem
; 64(19): 14757-14772, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34597046
6.
Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
J Med Chem
; 63(2): 656-675, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31858797
7.
A Versatile Method to Determine the Cellular Bioavailability of Small-Molecule Inhibitors.
J Med Chem
; 60(1): 157-169, 2017 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27935314
8.
Direct α-heteroarylation of amides (α to nitrogen) and ethers through a benzaldehyde-mediated photoredox reaction.
Chem Sci
; 7(3): 2111-2118, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29899938
9.
Structure-Based Design of 1,4-Dibenzoylpiperazines as ß-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction Inhibitors.
ACS Med Chem Lett
; 7(5): 508-13, 2016 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27190602
10.
Protocol for fragment hopping.
Methods Mol Biol
; 1289: 57-73, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25709033