Detalhe da pesquisa
1.
Molecular mechanism by which a potent hepatitis C virus NS3-NS4A protease inhibitor overcomes emergence of resistance.
J Biol Chem
; 288(8): 5673-81, 2013 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23271737
2.
Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.
J Biol Chem
; 286(13): 11434-43, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21270126
3.
In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335.
Antimicrob Agents Chemother
; 56(1): 569-72, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22024816
4.
Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease.
Antimicrob Agents Chemother
; 54(11): 4611-8, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20823284
5.
Protease and helicase activities of hepatitis C virus genotype 4, 5, and 6 NS3-NS4A proteins.
Biochem Biophys Res Commun
; 391(1): 692-7, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19944069
6.
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.
Nature
; 426(6963): 186-9, 2003 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-14578911
7.
Use of the fused NS4A peptide-NS3 protease domain to study the importance of the helicase domain for protease inhibitor binding to hepatitis C virus NS3-NS4A.
Biochemistry
; 48(4): 744-53, 2009 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19119853
8.
Peptide-based inhibitors of the hepatitis C virus NS3 protease: structure-activity relationship at the C-terminal position.
J Med Chem
; 47(10): 2511-22, 2004 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15115394
9.
Human rhinovirus VPg uridylylation AlphaScreen for high-throughput screening.
J Biomol Screen
; 19(2): 259-69, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23813021
10.
Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN 2061.
J Virol
; 78(14): 7352-9, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15220408
11.
An NS3 serine protease inhibitor abrogates replication of subgenomic hepatitis C virus RNA.
J Biol Chem
; 278(22): 20374-80, 2003 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-12646587