Detalhe da pesquisa
1.
Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV.
Neurobiol Dis
; 169: 105734, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35462006
2.
Targeting Mitochondria in Tumor-Associated Macrophages using a Dendrimer-Conjugated TSPO Ligand that Stimulates Antitumor Signaling in Glioblastoma.
Biomacromolecules
; 21(9): 3909-3922, 2020 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786523
3.
Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker.
Bioorg Med Chem
; 28(20): 115698, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33069080
4.
Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer.
Proteomics
; 19(21-22): e1800451, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31231915
5.
Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.
Nephrol Dial Transplant
; 33(8): 1343-1353, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420817
6.
Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs.
Mol Pharm
; 14(10): 3248-3257, 2017 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28763226
7.
Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain.
Neurobiol Dis
; 94: 116-28, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27326668
8.
Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.
Nephrol Dial Transplant
; 35(10): 1824, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31329939
9.
Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility.
Bioorg Med Chem Lett
; 25(21): 4787-4792, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26231156
10.
Small molecule glutaminase inhibitors block glutamate release from stimulated microglia.
Biochem Biophys Res Commun
; 443(1): 32-6, 2014 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24269238
11.
Netupitant and palonosetron trigger NK1 receptor internalization in NG108-15 cells.
Exp Brain Res
; 232(8): 2637-44, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24969614
12.
Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.
Biochem Biophys Res Commun
; 438(2): 243-8, 2013 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23850693
13.
Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase.
Bioorg Med Chem Lett
; 23(13): 3910-3, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23683589
14.
T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade.
JCI Insight
; 8(12)2023 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37166984
15.
Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy.
J Control Release
; 358: 27-42, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37054778
16.
Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice.
Pharmaceutics
; 15(9)2023 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37765332
17.
Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold.
Eur J Med Chem
; 259: 115674, 2023 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37536209
18.
A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis.
Sci Transl Med
; 15(708): eabn7491, 2023 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37556558
19.
Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer's disease.
Res Sq
; 2023 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37502930
20.
Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer's disease mouse model.
Transl Neurodegener
; 12(1): 56, 2023 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38049923