Detalhe da pesquisa
1.
EzMechanism: an automated tool to propose catalytic mechanisms of enzyme reactions.
Nat Methods
; 20(10): 1516-1522, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37735566
2.
The mission to ensure continued funding for excellent basic research.
EMBO Rep
; 24(7): e57498, 2023 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37227159
3.
Enzyme function and evolution through the lens of bioinformatics.
Biochem J
; 480(22): 1845-1863, 2023 11 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37991346
4.
GRaSP-web: a machine learning strategy to predict binding sites based on residue neighborhood graphs.
Nucleic Acids Res
; 50(W1): W392-W397, 2022 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35524575
5.
Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system.
Proc Natl Acad Sci U S A
; 118(8)2021 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33593901
6.
A global analysis of function and conservation of catalytic residues in enzymes.
J Biol Chem
; 295(2): 314-324, 2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31796628
7.
GRaSP: a graph-based residue neighborhood strategy to predict binding sites.
Bioinformatics
; 36(Suppl_2): i726-i734, 2020 12 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33381849
8.
Functional conservation in genes and pathways linking ageing and immunity.
Immun Ageing
; 18(1): 23, 2021 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33990202
9.
An automated protocol for modelling peptide substrates to proteases.
BMC Bioinformatics
; 21(1): 586, 2020 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33375946
10.
The impact of AlphaFold2 one year on.
Nat Methods
; 19(1): 15-20, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35017725
11.
VarMap: a web tool for mapping genomic coordinates to protein sequence and structure and retrieving protein structural annotations.
Bioinformatics
; 35(22): 4854-4856, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31192369
12.
Finding enzyme cofactors in Protein Data Bank.
Bioinformatics
; 35(18): 3510-3511, 2019 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30759194
13.
Using the drug-protein interactome to identify anti-ageing compounds for humans.
PLoS Comput Biol
; 15(1): e1006639, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30625143
14.
Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites.
Nucleic Acids Res
; 46(D1): D618-D623, 2018 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29106569
15.
Structural analysis of pathogenic mutations in the DYRK1A gene in patients with developmental disorders.
Hum Mol Genet
; 26(3): 519-526, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28053047
16.
Transform-MinER: transforming molecules in enzyme reactions.
Bioinformatics
; 34(20): 3597-3599, 2018 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29762650
17.
cuRRBS: simple and robust evaluation of enzyme combinations for reduced representation approaches.
Nucleic Acids Res
; 45(20): 11559-11569, 2017 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29036576
18.
Exploring the chemistry and evolution of the isomerases.
Proc Natl Acad Sci U S A
; 113(7): 1796-801, 2016 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26842835
19.
Integrating population variation and protein structural analysis to improve clinical interpretation of missense variation: application to the WD40 domain.
Hum Mol Genet
; 25(5): 927-35, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26740553
20.
EC-BLAST: a tool to automatically search and compare enzyme reactions.
Nat Methods
; 11(2): 171-4, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24412978