Detalhe da pesquisa
1.
Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.
Bioorg Med Chem Lett
; 26(2): 429-434, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26684851
2.
Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).
Bioorg Med Chem Lett
; 25(6): 1310-7, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25683622
3.
Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency.
Bioorg Med Chem Lett
; 24(15): 3641-6, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24961642
4.
An approach to the tricyclic core of madangamines based upon a biogenetic scheme.
Org Lett
; 7(12): 2437-40, 2005 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-15932217
5.
Identification of a novel orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor with efficacy in animal models of schizophrenia.
J Med Chem
; 58(2): 978-93, 2015 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25495129
6.
Discovery of a potent, selective, and orally active phosphodiesterase 10A inhibitor for the potential treatment of schizophrenia.
J Med Chem
; 57(10): 4196-212, 2014 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24758746
7.
Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).
J Med Chem
; 57(13): 5620-37, 2014 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24914612