Detalhe da pesquisa
1.
Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor.
Nat Chem Biol
; 10(1): 18-20, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24212135
2.
M2 Subtype preferring dibenzodiazepinone-type muscarinic receptor ligands: Effect of chemical homo-dimerization on orthosteric (and allosteric?) binding.
Bioorg Med Chem
; 23(14): 3970-90, 2015 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25650309
3.
The GPRC5A frameshift variant c.183del is not associated with increased breast cancer risk in BRCA1 mutation carriers.
Int J Cancer
; 144(7): 1761-1763, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30474284
4.
Semisynthetic analogues of toxiferine I and their pharmacological properties at α7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors.
J Nat Prod
; 77(9): 2006-13, 2014 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25192059
5.
Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors.
Angew Chem Int Ed Engl
; 52(2): 508-16, 2013 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23225228
6.
Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.
Mol Pharmacol
; 80(1): 163-73, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21498659
7.
LBH589 induces up to 10-fold SMN protein levels by several independent mechanisms and is effective even in cells from SMA patients non-responsive to valproate.
Hum Mol Genet
; 18(19): 3645-58, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19584083
8.
Allosteric ligands for G protein-coupled receptors: a novel strategy with attractive therapeutic opportunities.
Med Res Rev
; 30(3): 463-549, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19557759
9.
Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity.
FASEB J
; 23(2): 442-50, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18842964
10.
Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors.
Eur J Pharmacol
; 883: 173183, 2020 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32534072
11.
Ligand-Specific Allosteric Coupling Controls G-Protein-Coupled Receptor Signaling.
ACS Pharmacol Transl Sci
; 3(5): 859-867, 2020 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33073186
12.
Novel BQCA- and TBPB-Derived M1 Receptor Hybrid Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism.
ChemMedChem
; 14(14): 1349-1358, 2019 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31166078
13.
The peroxisome proliferator-activated receptor-gamma agonist troglitazone inhibits transforming growth factor-beta-mediated glioma cell migration and brain invasion.
Mol Cancer Ther
; 6(6): 1745-54, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17541035
14.
Characterization of methanthelinium binding and function at human M1-M5 muscarinic acetylcholine receptors.
Naunyn Schmiedebergs Arch Pharmacol
; 391(10): 1037-1052, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29938305
15.
First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.
J Med Chem
; 50(23): 5685-95, 2007 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17944454
16.
Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275.
Mol Cancer Ther
; 5(5): 1248-55, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16731757
17.
Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M1 and M2.
Medchemcomm
; 8(6): 1346-1359, 2017 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108847
18.
Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist.
Naunyn Schmiedebergs Arch Pharmacol
; 372(4): 267-76, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16362429
19.
Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors.
Naunyn Schmiedebergs Arch Pharmacol
; 372(5): 354-61, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16489449
20.
Rational design of partial agonists for the muscarinic m1 acetylcholine receptor.
J Med Chem
; 58(2): 560-76, 2015 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25478907