Detalhe da pesquisa
1.
Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS).
J Org Chem
; 89(10): 6639-6650, 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38651358
2.
Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1.
Bioorg Med Chem Lett
; 88: 129280, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37054759
3.
Synthesis of Bicyclo[1.1.0]butanes from Iodo-Bicyclo[1.1.1]pentanes.
Org Lett
; 25(44): 7947-7952, 2023 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37284784
4.
Amination of Nitro-Substituted Heteroarenes by Nucleophilic Substitution of Hydrogen.
Org Lett
; 24(41): 7643-7648, 2022 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36214755
5.
Structural and Thermal Characterization of Halogenated Azidopyridines: Under-Reported Synthons for Medicinal Chemistry.
Org Lett
; 24(3): 799-803, 2022 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34714083
6.
Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy.
ACS Med Chem Lett
; 12(3): 494-501, 2021 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33738077
7.
Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1.
ACS Med Chem Lett
; 12(2): 288-294, 2021 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33603977
8.
Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.
J Med Chem
; 64(19): 14247-14265, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34543572
9.
Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors.
ACS Med Chem Lett
; 12(7): 1143-1150, 2021 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34267885
10.
Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.
J Med Chem
; 64(21): 15549-15581, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34709814
11.
Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo.
J Med Chem
; 63(4): 1660-1670, 2020 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31990537
12.
Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672.
ACS Med Chem Lett
; 10(3): 300-305, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891130
13.
Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro.
Drug Metab Dispos
; 36(12): 2513-22, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18787056
14.
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3S)-3-benzylpiperidine in a series of potent CCR3 antagonists.
Bioorg Med Chem Lett
; 18(2): 586-95, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18160284
15.
The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton's tyrosine kinase.
J Chromatogr A
; 1487: 116-128, 2017 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28131592
16.
Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.
J Med Chem
; 49(24): 6946-9, 2006 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125246
17.
Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.
J Med Chem
; 59(19): 9173-9200, 2016 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27583770
18.
Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity.
J Med Chem
; 58(3): 1556-62, 2015 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25584393
19.
Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5.
ACS Med Chem Lett
; 6(4): 439-44, 2015 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25893046
20.
Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.
Bioorg Med Chem Lett
; 16(15): 3937-42, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16730979