Detalhe da pesquisa
1.
Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H1-antihistamines for insomnia.
Bioorg Med Chem Lett
; 22(1): 421-6, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22153347
2.
Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands.
Bioorg Med Chem Lett
; 18(17): 4817-22, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18682322
3.
Syntheses of tetrahydrothiophenes and tetrahydrofurans and studies of their derivatives as melanocortin-4 receptor ligands.
Bioorg Med Chem Lett
; 18(3): 1124-30, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18082401
4.
Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands.
Bioorg Med Chem Lett
; 18(6): 1931-8, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18294847
5.
Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors.
Bioorg Med Chem Lett
; 18(13): 3682-6, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18539031
6.
Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors.
Bioorg Med Chem Lett
; 18(11): 3328-32, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18445525
7.
Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor.
Bioorg Med Chem Lett
; 18(1): 129-36, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18032040
8.
Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists.
Bioorg Med Chem
; 16(10): 5606-18, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18417348
9.
Studies on the structure-activity relationship of the basic amine of phenylpiperazines as melanocortin-4 receptor antagonists.
Med Chem
; 4(1): 67-74, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18220971
10.
Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor.
J Med Chem
; 50(25): 6356-66, 2007 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-17994683
11.
Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia.
J Med Chem
; 50(22): 5249-52, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17918824
12.
Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor.
Bioorg Med Chem Lett
; 17(24): 6825-31, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17964151
13.
Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor.
Bioorg Med Chem Lett
; 17(23): 6546-52, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17933528
14.
4-{(2R)-[3-Aminopropionylamido]-3-(2,4-dichlorophenyl)propionyl}-1-{2-[(2-thienyl)ethylaminomethyl]phenyl}piperazine as a potent and selective melanocortin-4 receptor antagonist--design, synthesis, and characterization.
J Med Chem
; 47(27): 6821-30, 2004 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15615531
15.
Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain.
J Med Chem
; 51(22): 7265-72, 2008 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18954038
16.
Pyrrolidines as potent functional agonists of the human melanocortin-4 receptor.
Bioorg Med Chem Lett
; 17(18): 5165-70, 2007 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17629702
17.
Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity.
Bioorg Med Chem
; 15(15): 5166-76, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17544282
18.
Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor.
Bioorg Med Chem Lett
; 17(20): 5610-3, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17822895
19.
Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor.
Bioorg Med Chem Lett
; 16(17): 4674-8, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16777413
20.
Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor.
Bioorg Med Chem Lett
; 16(14): 3693-6, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16697187