Detalhe da pesquisa
1.
Modulation of α1ß3γ2 GABAA receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix.
Proc Natl Acad Sci U S A
; 118(8)2021 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33593898
2.
Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity.
Int J Mol Sci
; 21(7)2020 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32252459
3.
An intersubunit electrostatic interaction in the GABAA receptor facilitates its responses to benzodiazepines.
J Biol Chem
; 293(21): 8264-8274, 2018 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29622679
4.
Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.
Pharmacol Rev
; 66(2): 396-412, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24515646
5.
Endothelial fate mapping in mice with pulmonary hypertension.
Circulation
; 129(6): 692-703, 2014 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24201301
6.
Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors.
Alcohol Clin Exp Res
; 39(6): 962-8, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25973519
7.
Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.
Mol Pharmacol
; 86(6): 635-46, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25245406
8.
GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites.
J Neurochem
; 128(3): 363-75, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24117469
9.
Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders.
Int J Neuropsychopharmacol
; 17(6): 907-16, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24451653
10.
Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.
Alcohol Clin Exp Res
; 38(3): 595-603, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24164436
11.
Structural basis for alcohol modulation of a pentameric ligand-gated ion channel.
Proc Natl Acad Sci U S A
; 108(29): 12149-54, 2011 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21730162
12.
Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectin.
Biophys J
; 105(3): 640-7, 2013 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23931312
13.
Mutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo.
J Pharmacol Exp Ther
; 344(2): 489-500, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23230213
14.
Assessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor.
Anesthesiology
; 119(5): 1087-95, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23770602
15.
Molecular mechanism for the dual alcohol modulation of Cys-loop receptors.
PLoS Comput Biol
; 8(10): e1002710, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23055913
16.
Zinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol.
Alcohol Clin Exp Res
; 37(12): 2002-10, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23895467
17.
Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation.
Proc Natl Acad Sci U S A
; 107(17): 7987-92, 2010 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-20385800
18.
The TM2 6' position of GABA(A) receptors mediates alcohol inhibition.
J Pharmacol Exp Ther
; 340(2): 445-56, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22072732
19.
Charge and geometry of residues in the loop 2 ß hairpin differentially affect agonist and ethanol sensitivity in glycine receptors.
J Pharmacol Exp Ther
; 341(2): 543-51, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22357974
20.
Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.
J Pharmacol Exp Ther
; 340(2): 304-16, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22037201