Detalhe da pesquisa
1.
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.
Proc Natl Acad Sci U S A
; 108(17): 7177-82, 2011 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21482786
2.
Integration of human stem cell-derived in vitro systems and mouse preclinical models identifies complex pathophysiologic mechanisms in retinal dystrophy.
Front Cell Dev Biol
; 11: 1252547, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37691820
3.
Ocular phenotypes in a mouse model of impaired glucocerebrosidase activity.
Sci Rep
; 11(1): 6079, 2021 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33727605
4.
Publisher Correction: Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy.
Sci Rep
; 8(1): 13055, 2018 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30143651
5.
Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy.
Sci Rep
; 8(1): 7348, 2018 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29743491
6.
IL-33 amplifies an innate immune response in the degenerating retina.
J Exp Med
; 213(2): 189-207, 2016 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26755704
7.
Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR).
J Med Chem
; 56(7): 3090-101, 2013 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23473235
8.
Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.
ACS Med Chem Lett
; 4(1): 103-7, 2013 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900569
9.
mTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations.
Cancer Lett
; 326(2): 168-75, 2012 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22902509
10.
CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency.
Cancer Res
; 72(8): 2129-39, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22345154
11.
An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.
Cancer Res
; 72(22): 5812-23, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23139210
12.
Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity.
J Med Chem
; 55(24): 10958-71, 2012 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23199076
13.
Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine.
J Med Chem
; 54(9): 3426-35, 2011 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21495671
14.
Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab.
Clin Cancer Res
; 15(12): 4147-56, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19509167
15.
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.
Clin Cancer Res
; 15(14): 4649-64, 2009 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19567590