Detalhe da pesquisa
1.
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.
Mol Cell
; 81(15): 3128-3144.e7, 2021 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34216544
2.
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.
Mol Cell
; 81(15): 3227, 2021 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34358459
3.
The mechanistic role of cardiac glycosides in DNA damage response and repair signaling.
Cell Mol Life Sci
; 80(9): 250, 2023 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37584722
4.
Characterization and initial demonstration of in vivo efficacy of a novel heat-activated metalloenediyne anti-cancer agent.
Int J Hyperthermia
; 39(1): 405-413, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35236209
5.
Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku-DNA interaction.
Nucleic Acids Res
; 48(20): 11536-11550, 2020 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33119767
6.
Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) independent of downstream damage response (DDR) pathways.
J Biol Chem
; 287(29): 24263-72, 2012 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22621925
7.
Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma.
Biochem Biophys Res Commun
; 439(4): 586-90, 2013 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24041688
8.
Ku-DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks.
NAR Cancer
; 5(1): zcad003, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36755959
9.
ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe.
NAR Cancer
; 5(1): zcac045, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36644397
10.
Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response.
ChemMedChem
; 17(21): e202200415, 2022 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36054918
11.
In Vivo Targeting Replication Protein A for Cancer Therapy.
Front Oncol
; 12: 826655, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35251993
12.
Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair.
Front Oncol
; 12: 850883, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35463312
13.
OB-Folds and Genome Maintenance: Targeting Protein-DNA Interactions for Cancer Therapy.
Cancers (Basel)
; 13(13)2021 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34283091
14.
Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct.
Biochemistry
; 49(4): 669-78, 2010 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20028083
15.
Intrinsic hTRF1 fluorescence quenching reveals details of telomere DNA binding activity: impact of DNA length, structure and position of telomeric repeats.
Arch Biochem Biophys
; 493(2): 207-12, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19887064
16.
A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining.
Nucleic Acids Res
; 36(12): 4022-31, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18515838
17.
Structure-Guided Optimization of Replication Protein A (RPA)-DNA Interaction Inhibitors.
ACS Med Chem Lett
; 11(6): 1118-1124, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32550990
18.
Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A Is Mediated by Replication Protein A in Ovarian Cancer.
Mol Cancer Res
; 18(11): 1699-1710, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32801161
19.
ATM mediates repression of DNA end-degradation in an ATP-dependent manner.
DNA Repair (Amst)
; 7(3): 464-75, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18207464
20.
Molecular analysis of Ku redox regulation.
BMC Mol Biol
; 10: 86, 2009 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-19715578