Detalhe da pesquisa
1.
2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors.
Bioorg Med Chem Lett
; 22(17): 5392-5, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22877629
2.
Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
Bioorg Med Chem Lett
; 21(8): 2394-9, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21414779
3.
Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity.
J Med Chem
; 51(6): 1637-48, 2008 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18278858
4.
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
J Med Chem
; 51(6): 1681-94, 2008 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18321037
5.
N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR.
Bioorg Med Chem Lett
; 18(3): 1172-6, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18083554
6.
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
J Med Chem
; 49(16): 4981-91, 2006 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16884310
7.
Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.
J Med Chem
; 49(19): 5671-86, 2006 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16970394
8.
Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.
J Med Chem
; 56(11): 4320-42, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23701517
9.
Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.
J Med Chem
; 56(24): 10003-15, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24294969
10.
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties.
Bioorg Med Chem Lett
; 17(8): 2299-304, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17276681
11.
Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.
Bioorg Med Chem Lett
; 17(8): 2305-9, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17280833