Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Variations in MHC Class II Antigen Processing and Presentation in Health and Disease.

Unanue, Emil R; Turk, Vito; Neefjes, Jacques.

Annu Rev Immunol ; 34: 265-97, 2016 05 20.

Artigo em Inglês | MEDLINE | ID: mdl-26907214

2.

Antigen presentation in the autoimmune diabetes of the NOD mouse.

Unanue, Emil R.

Annu Rev Immunol ; 32: 579-608, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-24499272

3.

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy.

Molgora, Martina; Esaulova, Ekaterina; Vermi, William; Hou, Jinchao; Chen, Yun; Luo, Jingqin; Brioschi, Simone; Bugatti, Mattia; Omodei, Andrea Salvatore; Ricci, Biancamaria; Fronick, Catrina; Panda, Santosh K; Takeuchi, Yoshiko; Gubin, Matthew M; Faccio, Roberta; Cella, Marina; Gilfillan, Susan; Unanue, Emil R; Artyomov, Maxim N; Schreiber, Robert D; Colonna, Marco.

Cell ; 182(4): 886-900.e17, 2020 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-32783918

4.

The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides.

Wan, Xiaoxiao; Vomund, Anthony N; Peterson, Orion J; Chervonsky, Alexander V; Lichti, Cheryl F; Unanue, Emil R.

Nat Immunol ; 21(4): 455-463, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-32152506

5.

Publisher Correction: The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides.

Wan, Xiaoxiao; Vomund, Anthony N; Peterson, Orion J; Chervonsky, Alexander V; Lichti, Cheryl F; Unanue, Emil R.

Nat Immunol ; 21(5): 589, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32238948

6.

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.

Ulland, Tyler K; Song, Wilbur M; Huang, Stanley Ching-Cheng; Ulrich, Jason D; Sergushichev, Alexey; Beatty, Wandy L; Loboda, Alexander A; Zhou, Yingyue; Cairns, Nigel J; Kambal, Amal; Loginicheva, Ekaterina; Gilfillan, Susan; Cella, Marina; Virgin, Herbert W; Unanue, Emil R; Wang, Yaming; Artyomov, Maxim N; Holtzman, David M; Colonna, Marco.

Cell ; 170(4): 649-663.e13, 2017 Aug 10.

Artigo em Inglês | MEDLINE | ID: mdl-28802038

7.

MHC-II neoantigens shape tumour immunity and response to immunotherapy.

Alspach, Elise; Lussier, Danielle M; Miceli, Alexander P; Kizhvatov, Ilya; DuPage, Michel; Luoma, Adrienne M; Meng, Wei; Lichti, Cheryl F; Esaulova, Ekaterina; Vomund, Anthony N; Runci, Daniele; Ward, Jeffrey P; Gubin, Matthew M; Medrano, Ruan F V; Arthur, Cora D; White, J Michael; Sheehan, Kathleen C F; Chen, Alex; Wucherpfennig, Kai W; Jacks, Tyler; Unanue, Emil R; Artyomov, Maxim N; Schreiber, Robert D.

Nature ; 574(7780): 696-701, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-31645760

8.

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides.

Wan, Xiaoxiao; Zinselmeyer, Bernd H; Zakharov, Pavel N; Vomund, Anthony N; Taniguchi, Ruth; Santambrogio, Laura; Anderson, Mark S; Lichti, Cheryl F; Unanue, Emil R.

Nature ; 560(7716): 107-111, 2018 08.

Artigo em Inglês | MEDLINE | ID: mdl-30022165

9.

A minor subset of Batf3-dependent antigen-presenting cells in islets of Langerhans is essential for the development of autoimmune diabetes.

Ferris, Stephen T; Carrero, Javier A; Mohan, James F; Calderon, Boris; Murphy, Kenneth M; Unanue, Emil R.

Immunity ; 41(4): 657-69, 2014 Oct 16.

Artigo em Inglês | MEDLINE | ID: mdl-25367577

10.

Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.

Epelman, Slava; Lavine, Kory J; Beaudin, Anna E; Sojka, Dorothy K; Carrero, Javier A; Calderon, Boris; Brija, Thaddeus; Gautier, Emmanuel L; Ivanov, Stoyan; Satpathy, Ansuman T; Schilling, Joel D; Schwendener, Reto; Sergin, Ismail; Razani, Babak; Forsberg, E Camilla; Yokoyama, Wayne M; Unanue, Emil R; Colonna, Marco; Randolph, Gwendalyn J; Mann, Douglas L.

Immunity ; 40(1): 91-104, 2014 Jan 16.

Artigo em Inglês | MEDLINE | ID: mdl-24439267

11.

Cytocidal macrophages in symbiosis with CD4 and CD8 T cells cause acute diabetes following checkpoint blockade of PD-1 in NOD mice.

Hu, Hao; Zakharov, Pavel N; Peterson, Orion J; Unanue, Emil R.

Proc Natl Acad Sci U S A ; 117(49): 31319-31330, 2020 12 08.

Artigo em Inglês | MEDLINE | ID: mdl-33229539

12.

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes.

Mohan, James F; Levisetti, Matteo G; Calderon, Boris; Herzog, Jeremy W; Petzold, Shirley J; Unanue, Emil R.

Nat Immunol ; 11(4): 350-4, 2010 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-20190756

13.

CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.

Ise, Wataru; Kohyama, Masako; Nutsch, Katherine M; Lee, Hyang Mi; Suri, Anish; Unanue, Emil R; Murphy, Theresa L; Murphy, Kenneth M.

Nat Immunol ; 11(2): 129-35, 2010 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-20037585

14.

CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes.

Edelson, Brian T; Bradstreet, Tara R; Hildner, Kai; Carrero, Javier A; Frederick, Katherine E; KC, Wumesh; Belizaire, Roger; Aoshi, Taiki; Schreiber, Robert D; Miller, Mark J; Murphy, Theresa L; Unanue, Emil R; Murphy, Kenneth M.

Immunity ; 35(2): 236-48, 2011 Aug 26.

Artigo em Inglês | MEDLINE | ID: mdl-21867927

15.

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice.

Carrero, Javier A; McCarthy, Derrick P; Ferris, Stephen T; Wan, Xiaoxiao; Hu, Hao; Zinselmeyer, Bernd H; Vomund, Anthony N; Unanue, Emil R.

Proc Natl Acad Sci U S A ; 114(48): E10418-E10427, 2017 11 28.

Artigo em Inglês | MEDLINE | ID: mdl-29133420

16.

The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse.

Unanue, Emil R; Ferris, Stephen T; Carrero, Javier A.

Immunol Rev ; 272(1): 183-201, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27319351

17.

The resident macrophages in murine pancreatic islets are constantly probing their local environment, capturing beta cell granules and blood particles.

Zinselmeyer, Bernd H; Vomund, Anthony N; Saunders, Brian T; Johnson, Michael W; Carrero, Javier A; Unanue, Emil R.

Diabetologia ; 61(6): 1374-1383, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29589072

18.

Listeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice.

Valderrama, Carolina; Clark, Amy; Urano, Fumihiko; Unanue, Emil R; Carrero, Javier A.

Eur J Immunol ; 47(5): 830-840, 2017 05.

Artigo em Inglês | MEDLINE | ID: mdl-28267207

19.

Herman Eisen (1918-2014).

Chakraborty, Arup K; Unanue, Emil R.

Immunity ; 41(6): 869-70, 2014 Dec 18.

Artigo em Inglês | MEDLINE | ID: mdl-25667944

20.

Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.

Vomund, Anthony N; Zinselmeyer, Bernd H; Hughes, Jing; Calderon, Boris; Valderrama, Carolina; Ferris, Stephen T; Wan, Xiaoxiao; Kanekura, Kohsuke; Carrero, Javier A; Urano, Fumihiko; Unanue, Emil R.

Proc Natl Acad Sci U S A ; 112(40): E5496-502, 2015 Oct 06.

Artigo em Inglês | MEDLINE | ID: mdl-26324934

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