Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.

Urgaonkar, Sameer; Nosol, Kamil; Said, Ahmed M; Nasief, Nader N; Bu, Yahao; Locher, Kaspar P; Lau, Johnson Y N; Smolinski, Michael P.

J Med Chem ; 65(1): 191-216, 2022 01 13.

Artigo em Inglês | MEDLINE | ID: mdl-34928144

2.

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.

Barker, Robert H; Urgaonkar, Sameer; Mazitschek, Ralph; Celatka, Cassandra; Skerlj, Renato; Cortese, Joseph F; Tyndall, Erin; Liu, Hanlan; Cromwell, Mandy; Sidhu, Amar Bir; Guerrero-Bravo, Jose E; Crespo-Llado, Keila N; Serrano, Adelfa E; Lin, Jing-Wen; Janse, Chris J; Khan, Shahid M; Duraisingh, Manoj; Coleman, Bradley I; Angulo-Barturen, Inigo; Jiménez-Díaz, María Belén; Magán, Noemí; Gomez, Vanesa; Ferrer, Santiago; Martínez, María Santos; Wittlin, Sergio; Papastogiannidis, Petros; O'Shea, Thomas; Klinger, Jeffrey D; Bree, Mark; Lee, Edward; Levine, Mikaela; Wiegand, Roger C; Munoz, Benito; Wirth, Dyann F; Clardy, Jon; Bathurst, Ian; Sybertz, Edmund.

Antimicrob Agents Chemother ; 55(6): 2612-22, 2011 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21422215

3.

Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.

Smolinski, Michael P; Urgaonkar, Sameer; Pitzonka, Laura; Cutler, Murray; Lee, GwanSun; Suh, Kwee Hyun; Lau, Johnson Y N.

J Med Chem ; 64(7): 3677-3693, 2021 04 08.

Artigo em Inglês | MEDLINE | ID: mdl-33729781

4.

Water solubilization of DDGS via derivatization with phosphite esters.

Oshel, Reed E; Nandakumar, Mecheril V; Urgaonkar, Sameer; Hendricker, David G; Verkade, John G.

Bioresour Technol ; 99(12): 5193-205, 2008 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-18063363

5.

N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli.

Mukherjee, Shubhasish; Robinson, Carolyn A; Howe, Andrew G; Mazor, Tali; Wood, Peter A; Urgaonkar, Sameer; Hebert, Alan M; Raychaudhuri, Debabrata; Shaw, Jared T.

Bioorg Med Chem Lett ; 17(23): 6651-5, 2007 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-17923406

6.

Synthesis of (-)-viriditoxin: a 6,6'-binaphthopyran-2-one that targets the bacterial cell division protein FtsZ.

Park, Young Sam; Grove, Charles I; González-López, Marcos; Urgaonkar, Sameer; Fettinger, James C; Shaw, Jared T.

Angew Chem Int Ed Engl ; 50(16): 3730-3, 2011 Apr 11.

Artigo em Inglês | MEDLINE | ID: mdl-21413107

7.

P(i-BuNCH2CH2)3N: an efficient promoter for the nucleophilic aromatic substitution reaction of aryl fluorides with aryl TBDMS (or TMS) ethers.

Urgaonkar, Sameer; Verkade, John G.

Org Lett ; 7(15): 3319-22, 2005 Jul 21.

Artigo em Inglês | MEDLINE | ID: mdl-16018650

8.

A highly effective catalyst system for the Pd-catalyzed amination of vinyl bromides and chlorides.

Venkat Reddy, Chinta Reddy; Urgaonkar, Sameer; Verkade, John G.

Org Lett ; 7(20): 4427-30, 2005 Sep 29.

Artigo em Inglês | MEDLINE | ID: mdl-16178550

9.

Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.

Urgaonkar, Sameer; La Pierre, Henry S; Meir, Israel; Lund, Henrik; RayChaudhuri, Debabrata; Shaw, Jared T.

Org Lett ; 7(25): 5609-12, 2005 Dec 08.

Artigo em Inglês | MEDLINE | ID: mdl-16321003

10.

Separation and characterization of underivatized oligosaccharides using liquid chromatography and liquid chromatography-electrospray ionization mass spectrometry.

Liu, Ying; Urgaonkar, Sameer; Verkade, John G; Armstrong, Daniel W.

J Chromatogr A ; 1079(1-2): 146-52, 2005 Jun 24.

Artigo em Inglês | MEDLINE | ID: mdl-16038300

11.

P[N(i-Bu)CH2CH2]3N: a versatile ligand for the Pd-catalyzed amination of aryl chlorides.

Urgaonkar, Sameer; Nagarajan, M; Verkade, John G.

Org Lett ; 5(6): 815-8, 2003 Mar 20.

Artigo em Inglês | MEDLINE | ID: mdl-12633079

12.

Pd2(dba)3/P(i-BuNCH2CH2)3N-catalyzed Stille cross-coupling of aryl chlorides.

Su, Weiping; Urgaonkar, Sameer; Verkade, John G.

Org Lett ; 6(9): 1421-4, 2004 Apr 29.

Artigo em Inglês | MEDLINE | ID: mdl-15101757

13.

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.

Dong, Carolyn K; Urgaonkar, Sameer; Cortese, Joseph F; Gamo, Francisco-Javier; Garcia-Bustos, Jose F; Lafuente, Maria J; Patel, Vishal; Ross, Leila; Coleman, Bradley I; Derbyshire, Emily R; Clish, Clary B; Serrano, Adelfa E; Cromwell, Mandy; Barker, Robert H; Dvorin, Jeffrey D; Duraisingh, Manoj T; Wirth, Dyann F; Clardy, Jon; Mazitschek, Ralph.

Chem Biol ; 18(12): 1602-10, 2011 Dec 23.

Artigo em Inglês | MEDLINE | ID: mdl-22195562

14.

A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity.

Urgaonkar, Sameer; Cortese, Joseph F; Barker, Robert H; Cromwell, Mandy; Serrano, Adelfa E; Wirth, Dyann F; Clardy, Jon; Mazitschek, Ralph.

Org Lett ; 12(18): 3998-4001, 2010 Sep 17.

Artigo em Inglês | MEDLINE | ID: mdl-20718474

15.

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.

Patel, Vishal; Mazitschek, Ralph; Coleman, Bradley; Nguyen, Cokey; Urgaonkar, Sameer; Cortese, Joseph; Barker, Robert H; Greenberg, Edward; Tang, Weiping; Bradner, James E; Schreiber, Stuart L; Duraisingh, Manoj T; Wirth, Dyann F; Clardy, Jon.

J Med Chem ; 52(8): 2185-7, 2009 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-19317450

16.

Synthesis of kaempferitrin.

Urgaonkar, Sameer; Shaw, Jared T.

J Org Chem ; 72(12): 4582-5, 2007 Jun 08.

Artigo em Inglês | MEDLINE | ID: mdl-17497804

17.

Scope and limitations of Pd2(dba)3/P(i-BuNCH2CH2)3N-catalyzed Buchwald-Hartwig amination reactions of aryl chlorides.

Urgaonkar, Sameer; Verkade, John G.

J Org Chem ; 69(26): 9135-42, 2004 Dec 24.

Artigo em Inglês | MEDLINE | ID: mdl-15609947

18.

Ligand-, copper-, and amine-free sonogashira reaction of aryl iodides and bromides with terminal alkynes.

Urgaonkar, Sameer; Verkade, John G.

J Org Chem ; 69(17): 5752-5, 2004 Aug 20.

Artigo em Inglês | MEDLINE | ID: mdl-15307751

19.

P(i-BuNCH2CH2)3N: an effective ligand in the palladium-catalyzed amination of aryl bromides and iodides.

Urgaonkar, Sameer; Nagarajan, M; Verkade, J G.

J Org Chem ; 68(2): 452-9, 2003 Jan 24.

Artigo em Inglês | MEDLINE | ID: mdl-12530871

20.

Application of a new bicyclic triaminophosphine ligand in Pd-catalyzed Buchwald-Hartwig amination reactions of aryl chlorides, bromides, and iodides.

Urgaonkar, Sameer; Xu, Ju-Hua; Verkade, John G.

J Org Chem ; 68(22): 8416-23, 2003 Oct 31.

Artigo em Inglês | MEDLINE | ID: mdl-14575466

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Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.

Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.

Water solubilization of DDGS via derivatization with phosphite esters.

N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli.

Synthesis of (-)-viriditoxin: a 6,6'-binaphthopyran-2-one that targets the bacterial cell division protein FtsZ.

P(i-BuNCH2CH2)3N: an efficient promoter for the nucleophilic aromatic substitution reaction of aryl fluorides with aryl TBDMS (or TMS) ethers.

A highly effective catalyst system for the Pd-catalyzed amination of vinyl bromides and chlorides.

Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.

Separation and characterization of underivatized oligosaccharides using liquid chromatography and liquid chromatography-electrospray ionization mass spectrometry.

P[N(i-Bu)CH2CH2]3N: a versatile ligand for the Pd-catalyzed amination of aryl chlorides.

Pd2(dba)3/P(i-BuNCH2CH2)3N-catalyzed Stille cross-coupling of aryl chlorides.

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.

A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity.

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.

Synthesis of kaempferitrin.

Scope and limitations of Pd2(dba)3/P(i-BuNCH2CH2)3N-catalyzed Buchwald-Hartwig amination reactions of aryl chlorides.

Ligand-, copper-, and amine-free sonogashira reaction of aryl iodides and bromides with terminal alkynes.

P(i-BuNCH2CH2)3N: an effective ligand in the palladium-catalyzed amination of aryl bromides and iodides.

Application of a new bicyclic triaminophosphine ligand in Pd-catalyzed Buchwald-Hartwig amination reactions of aryl chlorides, bromides, and iodides.