Detalhe da pesquisa
1.
Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module.
Mol Cell
; 71(2): 343-351.e4, 2018 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30029007
2.
Effective Inhibition of TDP-43 Aggregation by Native State Stabilization.
Angew Chem Int Ed Engl
; 63(3): e202314587, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37949836
3.
Auxiliary domains of the HrpB bacterial DExH-box helicase shape its RNA preferences.
RNA Biol
; 17(5): 637-650, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32050838
4.
Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1.
Proc Natl Acad Sci U S A
; 114(8): 1982-1987, 2017 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28167755
5.
Structure of lipid kinase p110ß/p85ß elucidates an unusual SH2-domain-mediated inhibitory mechanism.
Mol Cell
; 41(5): 567-78, 2011 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21362552
6.
Different inhibition of Gßγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gßγ-dependent regulator of PI3Kγ enzymatic activity.
Biochem J
; 469(1): 59-69, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26173259
7.
Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).
Proc Natl Acad Sci U S A
; 110(47): 18862-7, 2013 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24190998
8.
Probing the dynamic regulation of peripheral membrane proteins using hydrogen deuterium exchange-MS (HDX-MS).
Biochem Soc Trans
; 43(5): 773-86, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26517882
9.
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).
Proc Natl Acad Sci U S A
; 109(38): 15259-64, 2012 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22949682
10.
Non-Invasive Delivery of Negatively Charged Nanobodies by Anodal Iontophoresis: When Electroosmosis Dominates Electromigration.
Pharmaceutics
; 16(4)2024 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38675200
11.
Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in Plasmodium falciparum.
RSC Chem Biol
; 5(1): 19-29, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38179191
12.
Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation.
Science
; 381(6663): 1217-1225, 2023 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37708276
13.
Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii.
Elife
; 122023 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37014051
14.
Inactivation mechanisms of influenza A virus under pH conditions encountered in aerosol particles as revealed by whole-virus HDX-MS.
mSphere
; 8(5): e0022623, 2023 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37594288
15.
Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii.
Nat Commun
; 13(1): 345, 2022 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35039477
16.
Conoid extrusion regulates glideosome assembly to control motility and invasion in Apicomplexa.
Nat Microbiol
; 7(11): 1777-1790, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36109645
17.
Structural basis of phosphatidylinositol 3-kinase C2α function.
Nat Struct Mol Biol
; 29(3): 218-228, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35256802
18.
SUV39 SET domains mediate crosstalk of heterochromatic histone marks.
Elife
; 102021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34524082
19.
Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion.
Nat Commun
; 12(1): 3788, 2021 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34145271
20.
Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b.
Nat Commun
; 12(1): 1538, 2021 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33750786