Detalhe da pesquisa
1.
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Cell
; 156(4): 771-85, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24529379
2.
Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA).
Proc Natl Acad Sci U S A
; 114(50): E10755-E10762, 2017 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29183982
3.
mTORC1 activity oscillates throughout the cell cycle promoting mitotic entry and differentially influencing autophagy induction.
bioRxiv
; 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38370755
4.
Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity.
J Biol Chem
; 287(6): 3823-32, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22184111
5.
The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish.
J Dev Biol
; 11(3)2023 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37489330
6.
Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex.
iScience
; 25(11): 105458, 2022 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36388985
7.
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.
Elife
; 102021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33646118
8.
IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex.
JCI Insight
; 5(7)2020 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32271165
9.
Molecular logic of mTORC1 signalling as a metabolic rheostat.
Nat Metab
; 1(3): 321-333, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32694720
10.
Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R.
Oncotarget
; 8(24): 38099-38112, 2017 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28498820
11.
mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.
Cancer Cell
; 32(5): 624-638.e5, 2017 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29056426
12.
Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi.
Sci Signal
; 8(393): rs9, 2015 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26350902
13.
Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish.
Dis Model Mech
; 7(1): 63-71, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24092877
14.
GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder.
Front Mol Neurosci
; 5: 1, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22319467
15.
Glycogen synthase kinase-3 is essential for ß-arrestin-2 complex formation and lithium-sensitive behaviors in mice.
J Clin Invest
; 121(9): 3756-62, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21821916