Detalhe da pesquisa
1.
Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening.
J Enzyme Inhib Med Chem
; 36(1): 198-206, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33530764
2.
6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum.
Bioorg Med Chem
; 27(24): 115158, 2019 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31685330
3.
Characterization of the binding of a glycosylated serine protease from Euphorbia cf. lactea latex to human fibrinogen.
Biotechnol Appl Biochem
; 64(6): 862-870, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28150441
4.
Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.
Proc Natl Acad Sci U S A
; 109(42): 16823-8, 2012 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23035243
5.
Single-Molecule Analysis of SARS-CoV-2 Double-Stranded Polynucleotides Using Solid-State Nanopore with AI-Assisted Detection and Classification: Implications for Understanding Disease Severity.
ACS Appl Bio Mater
; 7(2): 1017-1027, 2024 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38194666
6.
Characterizing a visual lateral flow device for rapid SARS-CoV-2 virus protein detection: pre-clinical and system assessment.
Anal Methods
; 16(17): 2740-2750, 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38634326
7.
Key interactions of pyrimethamine derivatives specific to wild-type and mutant P. falciparum dihydrofolate reductase based on 3D-QSAR, MD simulations and quantum chemical calculations.
J Biomol Struct Dyn
; 41(12): 5728-5743, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-35815526
8.
Discovery of rigid biphenyl Plasmodium falciparum DHFR inhibitors using a fragment linking strategy.
RSC Med Chem
; 14(9): 1755-1766, 2023 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37731689
9.
Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil.
Antimicrob Agents Chemother
; 56(7): 3928-35, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22526319
10.
Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase.
ACS Chem Biol
; 17(7): 1691-1702, 2022 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35715223
11.
MANORAA: A machine learning platform to guide protein-ligand design by anchors and influential distances.
Structure
; 30(1): 181-189.e5, 2022 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34614393
12.
Molecular Docking Studies, Synthesis and Biological Evaluation of Substituted Pyrimidine-2,4-diamines as Inhibitors of Plasmodium falciparum Dihydrofolate Reductase.
ChemMedChem
; 17(22): e202200418, 2022 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36193872
13.
Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities.
Eur J Med Chem
; 195: 112263, 2020 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32294614
14.
Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases.
J Comput Aided Mol Des
; 23(4): 241-52, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19156529
15.
Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance.
ACS Med Chem Lett
; 9(12): 1235-1240, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613332
16.
The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase.
Int J Parasitol
; 37(7): 787-93, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17320089
17.
Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum.
J Med Chem
; 47(2): 345-54, 2004 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14711307
18.
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.
J Med Chem
; 45(6): 1244-52, 2002 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-11881993
19.
Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.
J Med Chem
; 47(3): 673-80, 2004 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-14736247
20.
Trypanosomal dihydrofolate reductase reveals natural antifolate resistance.
ACS Chem Biol
; 6(9): 905-11, 2011 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21650210