Detalhe da pesquisa
1.
Cocaine-induced locomotor stimulation involves autophagic degradation of the dopamine transporter.
Mol Psychiatry
; 26(2): 370-382, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33414501
2.
Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker.
Bioorg Med Chem
; 28(20): 115698, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33069080
3.
Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs.
Mol Pharm
; 16(10): 4292-4301, 2019 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31503493
4.
"Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4": Revisiting the Significance of the Epoxide Intermediate and Glutathione Trapping.
Chem Res Toxicol
; 33(2): 281-282, 2020 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31833760
5.
A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis.
Sci Transl Med
; 15(708): eabn7491, 2023 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37556558
6.
Thieno[2,3-d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1).
J Med Chem
; 65(4): 3218-3228, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35119273
7.
Whole blood or plasma: what is the ideal matrix for pharmacokinetic-driven drug candidate selection?
Future Med Chem
; 13(2): 157-171, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33275044
8.
Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement.
Curr Drug Metab
; 22(9): 735-745, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34488583
9.
Three-dimensional aspects of formulation excipients in drug discovery: a critical assessment on orphan excipients, matrix effects and drug interactions.
J Pharm Anal
; 10(6): 522-531, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33425449
10.
Critical Assessment of Pharmacokinetic Drug-Drug Interaction Potential of Tofacitinib, Baricitinib and Upadacitinib, the Three Approved Janus Kinase Inhibitors for Rheumatoid Arthritis Treatment.
Drug Saf
; 43(8): 711-725, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32367507
11.
Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease.
J Med Chem
; 63(11): 6028-6056, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32298582
12.
The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor.
Mol Cancer Ther
; 19(2): 397-408, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31594823
13.
Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.
J Med Chem
; 62(7): 3524-3538, 2019 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30892035
14.
Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists.
J Med Chem
; 62(18): 8631-8641, 2019 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31498617