Detalhe da pesquisa
1.
Aurones and derivatives as promising New Delhi metallo-ß-lactamase (NDM-1) inhibitors.
Bioorg Med Chem
; 97: 117559, 2024 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38109811
2.
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-ß-lactamase inhibitors.
Bioorg Med Chem
; 72: 116964, 2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36030663
3.
4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-ß-lactamase inhibitors.
Bioorg Chem
; 113: 105024, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34116340
4.
Zidovudine-ß-Lactam Pronucleoside Strategy for Selective Delivery into Gram-Negative Bacteria Triggered by ß-Lactamases.
ACS Infect Dis
; 9(8): 1546-1557, 2023 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37439673
5.
Structure-Based Optimization of 1,2,4-Triazole-3-Thione Derivatives: Improving Inhibition of NDM-/VIM-Type Metallo-ß-Lactamases and Synergistic Activity on Resistant Bacteria.
Pharmaceuticals (Basel)
; 16(12)2023 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38139809
6.
A fragment-based drug discovery strategy applied to the identification of NDM-1 ß-lactamase inhibitors.
Eur J Med Chem
; 240: 114599, 2022 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35841882
7.
1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-ß-Lactamase Inhibitors.
ChemMedChem
; 17(7): e202100699, 2022 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35050549
8.
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-ß-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates.
J Med Chem
; 65(24): 16392-16419, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36450011
9.
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-ß-lactamase inhibitors with re-sensitization activity.
Eur J Med Chem
; 226: 113873, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34626878
10.
Virtual screening identifies broad-spectrum ß-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases.
Sci Rep
; 10(1): 12763, 2020 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32728062
11.
4-(N-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-ß-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition.
Biomolecules
; 10(8)2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32717907
12.
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-ß-lactamase inhibitors.
Eur J Med Chem
; 208: 112720, 2020 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32937203