Detalhe da pesquisa
1.
Evaluation of amidoxime derivatives as prodrug candidates of potent bis-cationic antimalarials.
Bioorg Med Chem Lett
; 29(16): 2203-2207, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31255483
2.
Contribution of the precursors and interplay of the pathways in the phospholipid metabolism of the malaria parasite.
J Lipid Res
; 59(8): 1461-1471, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29853527
3.
High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death.
Antimicrob Agents Chemother
; 61(8)2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28607017
4.
An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei.
PLoS Pathog
; 11(5): e1004875, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25946070
5.
Uncovering new structural insights for antimalarial activity from cost-effective aculeatin-like derivatives.
Org Biomol Chem
; 13(7): 2064-77, 2015 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25519040
6.
New insight into the mechanism of accumulation and intraerythrocytic compartmentation of albitiazolium, a new type of antimalarial.
Antimicrob Agents Chemother
; 58(9): 5519-27, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25001307
7.
Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs.
Antimicrob Agents Chemother
; 58(5): 2586-97, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24550329
8.
Design, synthesis and evaluation of new tricyclic endoperoxides as potential antiplasmodial agents.
Org Biomol Chem
; 12(28): 5212-21, 2014 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24914508
9.
Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active.
Biochem J
; 450(1): 159-67, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23198904
10.
Composite aromatic boxes for enzymatic transformations of quaternary ammonium substrates.
Angew Chem Int Ed Engl
; 53(49): 13471-6, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25283789
11.
Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis.
PLoS Pathog
; 7(2): e1001286, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21379336
12.
A novel live-dead staining methodology to study malaria parasite viability.
Malar J
; 12: 190, 2013 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23758788
13.
CRIMALDDI: platform technologies and novel anti-malarial drug targets.
Malar J
; 12: 396, 2013 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24498961
14.
Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids.
Malar J
; 12: 71, 2013 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23433124
15.
Flexible synthesis and evaluation of diverse anti-Apicomplexa cyclic peptides.
J Org Chem
; 78(8): 3655-75, 2013 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23535138
16.
PG12, a phospholipid analog with potent antimalarial activity, inhibits Plasmodium falciparum CTP:phosphocholine cytidylyltransferase activity.
J Biol Chem
; 286(33): 28940-28947, 2011 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21705805
17.
Multiple roles for Plasmodium berghei phosphoinositide-specific phospholipase C in regulating gametocyte activation and differentiation.
Cell Microbiol
; 13(7): 955-66, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21518218
18.
Synergistic role of micronemal proteins in Toxoplasma gondii virulence.
J Exp Med
; 201(3): 453-63, 2005 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15684324
19.
Antiplasmodial properties of acyl-lysyl oligomers in culture and animal models of malaria.
Antimicrob Agents Chemother
; 55(8): 3803-11, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21646484
20.
Symmetrical choline-derived dications display strong anti-kinetoplastid activity.
J Antimicrob Chemother
; 66(1): 111-25, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078603