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BACKGROUND AND OBJECTIVES: Stroke is the rapid onset of neurological symptoms that persist for >24 hours or death due to vascular causes. Biochemical alterations indicate stroke severity and outlook. Serum calcium has an important role in signal transduction pathways and may influence the severity of stroke in the acute stages. Serum uric acid acts as an indicator of tissue infarction. However, serum calcium, albumin and uric acid are rarely tested in acute ischemic stroke for severity and short-term prognosis. MATERIALS AND METHODS: This is a 1-year, observational cross-sectional study of 65 individuals who experienced an acute ischemic stroke within 24 hours of onset. Patients with hemorrhagic stroke, chronic liver, and renal disease were excluded. At admission, serum calcium, albumin, and uric acid were measured along with the National Institute of Health Stroke Scale (NIHSS) severity. The Modified Rankin scale (MRS) grading done at the end of 1st week determined the short-term prognosis. RESULTS: In our 65-person study, stroke was common among 50-80-year-old patients. Participants included 45 (69.23%) males and 20 (30.77%) females. Male preponderance of the ratio 2.25:1 was observed. A total of 17 (26.15%) individuals had hypertension, 19 (29.23%) had overlapping comorbidities, six (9.23%) had diabetes, and five (7.69%) had coronary artery disease (CAD). Hypertension and diabetes did not show a significant correlation. Only low serum calcium was found to be positively correlated to NIHSS rating. Serum albumin and uric acid did not affect NIHSS severity. All three signals were unrelated to MRS. INTERPRETATION AND CONCLUSION: Low serum calcium exacerbates NIHSS. NIHSS was unrelated to albumin, uric acid, or demography. MRS grades were unaffected by three lab factors. In order to decrease bias and relate these three lab measures to acute ischemic stroke, large-scale prospective research is required.
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Biomarcadores , Cálcio , AVC Isquêmico , Albumina Sérica , Índice de Gravidade de Doença , Ácido Úrico , Humanos , Masculino , Feminino , Ácido Úrico/sangue , Cálcio/sangue , Pessoa de Meia-Idade , AVC Isquêmico/sangue , AVC Isquêmico/diagnóstico , Estudos Transversais , Idoso , Albumina Sérica/análise , Albumina Sérica/metabolismo , Biomarcadores/sangue , Prognóstico , Idoso de 80 Anos ou maisRESUMO
OBJECTIVE: The present study intend to determine the association of anatomical site and clinical outcome in intracerebral hemorrhage patients with or without intraventricular extension. METHODS: The present 1-year cross-sectional study included 56 patients presenting with spontaneous intracerebral hemorrhage with or without intraventricular extension. Relevant data were collected through a detailed interview with either the patient or the attender. Clinical examination was performed with the help of a predesigned and pretested proforma. Anatomical site of intracerebral hemorrhage and volume of ventricular bleed was estimated by computed tomography/magnetic resonance imagining scans. Clinical outcome was assessed based on modified Rankin scale score and Glasgow outcome scale. Mann-Whitney U test and chi-square test were employed in the analysis. RESULTS: The most common clinical presentations were neuronal deficits, speech disorder, and cranial nerve dysfunction. Hypertension was the most important risk factor observed among the patients. Age, gender, habits, severity of hypertension, duration of hypertension, and site of bleed (P > 0.05) were not significantly associated with outcome. However, clinical features including neuronal deficits (P = 0.01), cranial nerve palsy (P = 0.0002), altered sensorium (P = 0.004), vomiting (P = 0.0006), volume or quantum of bleed (P < 0.04), and IVE of ICH (P = 0.026; significantly affected the outcome. CONCLUSION: The present study revealed that immediate outcome of patients with intracerebral hemorrhage associated with the clinical presentation of patients, quantum of bleed, and intraventricular extension of bleed.
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Hemorragia Cerebral , Estudos Transversais , Humanos , Hipertensão , Prognóstico , Fatores de RiscoRESUMO
A new series of spiropyrrolidine compounds containing indole/indazole moieties as side chains have been accomplished via a one-pot multicomponent synthesis. The method uses the 1,3-dipolar cycloaddition reaction between N-alkylvinylindole/indazole and azomethine ylides, prepared in situ from cyclic/acyclic amino acids. The 1,3-dipolar cycloaddition proceeds efficiently under thermal conditions to afford the regio- and stereospecific cyclic adducts.
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The Poly(vinyl alcohol)/copper acetate/calcium acetate sol was prepared by sol-gel route. Poly(vinyl alcohol)/copper acetate/calcium acetate composite nanofibers were synthesized by electrospinning process. These nanofibers had an average diameter of 200 nm. Calcining these fibers at 1000 degrees C produced copper oxide/calcium oxide nanofibers with average diameter of 75 nm. These fibers were characterized by Atomic Force Microscopy, Scanning Electron Microscopy, Fourier Transform Infrared spectroscopy, powder X-ray Diffraction, Ultraviolet spectroscopy, dielectric study and Second Harmonic Generation (SHG) efficiency test. Band gap energy was calculated as 4.1 eV. SHG efficiency was found to be 1.7 times than that of KDP.
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Vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor is effective in reducing HbA1c levels in patients with type 2 diabetes (T2DM) when administered as monotherapy, dual or triple combination therapy. In India, Vildagliptin is commonly prescribed in T2DM patients because it reduces mean amplitude of glycemic excursion (MAGE), has lower risk of hypoglycemia and is weight neutral. Early combination therapy with vildagliptin and metformin is effective and well-tolerated in patients with T2DM, regardless of age or ethnicity. In view of already existing data on vildagliptin and the latest emerging clinical evidence, a group of endocrinologists, diabetologists and cardiologists convened for an expert group meeting to discuss the role and various combinations of vildagliptin in T2DM management. This practical document aims to guide Physicians and Specialists regarding the different available strengths and formulations of vildagliptin for the initiation and intensification of T2DM therapy.
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BACKGROUND: India has the second largest diabetic population (61 million) and tobacco users (275 million) in the world. Data on smoking cessation among diabetic patients are limited in low and middle income countries. The objective of the study was to document the effectiveness of diabetic specific smoking cessation counseling by a non-doctor health professional in addition to a cessation advice to quit, delivered by doctors. METHODS: In our parallel-group randomized controlled trial, we selected 224 adult diabetes patients aged 18 years or older who smoked in the last month, from two diabetes clinics in South India. Using a computer generated random sequence with block size four; the patients were randomized equally into intervention-1 and intervention-2 groups. Patients in both groups were asked and advised to quit smoking by a doctor and distributed diabetes specific education materials. The intervention-2 group received an additional diabetes specific 30 minutes counseling session using the 5As (Ask, Advise, Assess, Assist and Arrange), and 5 Rs (Relevance, Risks, Rewards, Roadblocks and Repetition) from a non-doctor health professional. Follow up data were available for 87.5% of patients at six months. The Quit Tobacco International Project is supported by a grant from the Fogarty International Centre of the US National Institutes of Health (RO1TW005969-01).The primary outcomes were quit rate (seven day smoking abstinence) and harm reduction (reduction of the number of cigarettes / bidis smoked per day > 50% of baseline use) at six months. RESULTS: In the intention to treat analysis, the odds for quitting was 8.4 [95% confidence interval (CI): 4.1-17.1] for intervention-2 group compared to intervention-1 group. Even among high level smokers the odds of quitting was similar. The odds of harm reduction was 1.9 (CI: 0.8-4.1) for intervention-2 group compared to intervention-1 group. CONCLUSIONS: The value addition of culturally sensitive diabetic specific cessation counseling sessions delivered by non-doctor health professional was an impressive and efficacious way of preventing smoking related diabetic complications. TRIAL REGISTRATION: Clinical Trial Registry of India (CTRI/2012/01/002327).
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Aconselhamento/métodos , Diabetes Mellitus/psicologia , Relações Profissional-Paciente , Abandono do Hábito de Fumar/métodos , Prevenção do Hábito de Fumar , Adulto , Idoso , Seguimentos , Humanos , Índia , Masculino , Pessoa de Meia-Idade , Educação de Pacientes como Assunto , Relações Médico-Paciente , Projetos Piloto , Avaliação de Programas e Projetos de Saúde , Comportamento de Redução do Risco , Abandono do Hábito de Fumar/estatística & dados numéricosRESUMO
Serum protein analysis for noninvasive quantification of airway inflammation in asthma is a promising research tool in the field of lung diseases. Cytokines are believed to have major role in inflammatory process of the airways of the lung. There is an imbalance between T-helper (Th)-2 cells, which secrete interleukin (IL)-4 and interleukin (IL)-13, and Th1 cells, which secrete interferon (IFN)-gamma in asthma. To test the hypothesis that serum IL-13 and IL-4 levels may be elevated whereas IFN-gamma would be decreased in this cohort of patients, a property that could make them possible candidate biomarkers in determining asthma occurrence and severity, we measured concentrations of IL-4, IL-13 and IFN-gamma in serum samples of 88 subjects (44 normal, 12 with mild asthma, 16 with moderate asthma, and 16 with severe asthma). Serum Levels of IL-4, IL-13, and IFN-gamma were determined by an enzyme-linked immune-sorbent assay (ELISA). Median serum level of IFN-gamma in asthmatic patients was 8.0 pg/ml, while it was 11.4 pg/ml in healthy controls. However, the difference was not significant. Among the different age groups in whom IFN-gamma was assessed, the highest median value in both cases and controls was observed in the age group of 31-40 years. The median serum level of IL-13 was 40.0 pg/ml in asthmatic patients and 58.25 pg/ml in healthy controls. The difference was not significant. On subgroup analysis, no significant difference of IFN-gamma and IL-13 between asthma of different severities was observed. The study also revealed nonsignificant difference of serum cytokines with the duration of asthma, number of allergens, and severity of sensitization. Normal serum levels of IFN-gamma and IL-13 in asthmatic patients suggest their neutral role in the inflammatory process; however, more studies are required to establish the effect of these cytokines in adulthood asthma in different ethnic populations.
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Asma/sangue , Interferon gama/sangue , Interleucina-13/sangue , Adulto , Alérgenos/imunologia , Asma/imunologia , Asma/patologia , Estudos de Casos e Controles , Demografia , Feminino , Humanos , Índia , Masculino , Pessoa de Meia-IdadeRESUMO
Twenty apparently healthy buffaloes were withdrawn of feed and water for 48 hours. Buffaloes were administered with fluids and were subjected to endoscopy every 12 hours. Olympus™ [GIF V70] flexible video endoscope was passed through the ventral nasal meatus, the pharynx, oesophagus and then into the reticulo-rumen in physically restrained buffaloes. The entire reticulum and part of the rumen could be visualized, when the animals were off feed and water for at least 48 hours and evacuations of rumen contents were done even after 48 hours of starvation to visualize the rumen in six buffaloes. The reticulum appeared light brown to pink coloured with honeycomb shape and the rumen appeared smooth, shiny pink, with numerous papillae throughout its surface. The procedure was well tolerated by all the buffaloes and satisfactory reticular and ruminal images could be obtained including biopsy.
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Bison , Búfalos , Animais , Estresse do Retículo Endoplasmático , Endoscopia Gastrointestinal/veterinária , Rúmen/patologia , ÁguaRESUMO
In the title hydrated complex, [Co(C15H10ClN3)2]Cl2·4H2O, the complete dication is generated by symmetry. The CoN6 moiety shows distortion from regular octa-hedral geometry with the trans bond angles of two N-Co-N units being 160.62â (9)°. In the crystal, O-Hâ¯Cl and C-Hâ¯O inter-actions link the components into (001) sheets. The title compound exhibits blue-light emission, as indicated by photoluminescence data, and a HOMO-LUMO energy separation of 2.23â eV was obtained from its diffuse reflectance spectrum.
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Soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) are important factors in immunological processes of inflammatory cell buildup in target tissues. Studies have suggested that these molecules could be important markers of inflammatory diseases. This study was undertaken to assess the levels of sICAM-1 and sE-selectin during an acute attack of asthma in adults and children and to establish normal values (95th percentile) in healthy control subjects. We analyzed serum levels of ICAM-1 and E-selectin in 120 children and adults obtained during an acute attack of asthma: 40 with severe and 80 with moderately severe attack, and 50 healthy subjects as controls by ELISA (enzyme linked immunosorbent assay). sICAM-1 from patients with asthma was significantly higher than healthy controls (P < 0.001) but not for sE-selectin (P = 0.778). Significant differences were observed in moderately severe attack versus controls and severe attack of asthma for sICAM-1. With 95th percentile levels as cutoff for normal values (sICAM-1 = 585.08 ng/ml, sE-selectin = 160.87 ng/ml), it was observed that 88.3% of subjects (sICAM-1) and 98.5% of subjects (sE-selectin) with an acute attack of asthma had levels within the normal range. Although mean serum levels of sICAM-1 are higher in asthmatics than normal controls, it may be necessary to establish individual baseline values for serial estimation to evaluate their clinical relevance.
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Asma/imunologia , Selectina E/sangue , Mediadores da Inflamação/sangue , Molécula 1 de Adesão Intercelular/sangue , Adolescente , Adulto , Asma/diagnóstico , Biomarcadores/sangue , Estudos de Casos e Controles , Criança , Pré-Escolar , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Índia , Lactente , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Índice de Gravidade de Doença , Regulação para Cima , Adulto JovemRESUMO
BACKGROUND: Within India, inter-regional disparities in burden of type 2 diabetes mellitus (DM) are expected because of varying lifestyles and demographic patterns. Hence, to estimate the prevalence of DM and impaired fasting glycaemia (IFG), and to explore the predictors of DM, a study was conducted in rural Kerala. METHODS: In 2007, a cross-sectional survey was conducted among 1990 adults (women: 1149; men: 841) of two Panchayat Wards in Venmony Panchayat, Chengannur Taluk, Kerala, India. Those who were already on drugs for DM and/or having fasting plasma glucose (FBS) > or = 126 mg/dL were considered as DMs; those with FBS 100 -125 mg/dL were considered as IFGs. Pearson's Chi-Square test and multiple logistic regression were used for statistical analysis. RESULTS: The response rate was 82.7 percent. The crude- and age-adjusted prevalence of DM was 14.6 percent and 12.5 percent respectively, and that of IFG was 5.1 percent and 4.6 percent respectively. The crude prevalence of hypertension (BP > or = 140/90), hypercholesterolemia (fasting total serum cholesterol > or = 200 mg/dL) and central obesity (WHR > or = 0.80 [women] and > or = 0.90 [men]) was 36.1 percent, 37.0 percent and 85.6 percent respectively. Adjusted for age and sex, DM was significantly associated with positive family history of DM [Odds ratio: 2.81; 95% CI (2.04-3.86)], high socioeconomic status [1.43; (1.04-1.95)], central obesity [3.91; (1.77-8.64)], hypercholesterolemia [1.93; (1.42-2.62)], and hypertension [1.71; (1.24-2.37)]. CONCLUSION: High prevalence of DM even in rural community validates the pandemic trend of DM. The coexistence of other non-communicable diseases amplifies the burden of DM. The impact of socioeconomic transition on the occurrence of DM needs to be explored further.
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Diabetes Mellitus Tipo 2/epidemiologia , Adolescente , Adulto , Feminino , Humanos , Hipercolesterolemia/epidemiologia , Hipertensão/epidemiologia , Índia/epidemiologia , Estilo de Vida , Masculino , Pessoa de Meia-Idade , Obesidade/epidemiologia , Prevalência , População Rural , Fatores Socioeconômicos , Adulto JovemRESUMO
A novel aggregation induced emission based 2-(1-(3, 5-bis(trifluoromethyl)phenyl)-4,5-diphenyl-1H-imidazol-2-yl) phenol (4) (IMD) fluorescent tags (FTs) was designed by simple acid catalyzed five-member N-heterocyclic ring forming reaction process. Powder X-ray diffraction results showed mechanofluorochromic properties of IMD FTs are easily reversible under external force due to the decrease in crystallinity. These IMD FTs also exhibits strong cyan-blue luminescence in solid state with high quantum efficiency. Detailed investigation of latent fingerprints (LFPs) showed permanent, immutable and unique pores that are distributed on the ridges. The visualization of such sweat pores opens new avenue in the field of forensic science. Hence, the prepared IMD FTs exhibit excellent Lipophicity (LP) properties, which endorse its possible applications for the visualization of sweat pores present in the LFPs. The LFPs visualized by IMD FTs exhibit excellent efficiency, sensitivity, selectivity, low background hindrance and less toxicity. The obtained result evident that the prepared FT and followed technique opens possible applications for the visualization of LFPs on various porous/semi-porous/non-porous surfaces under UV 365â¯nm light.
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Imidazóis/química , Luminescência , Animais , Humanos , Luz , SuorRESUMO
AIM: The primary objective of this document is to develop practice-based expert group opinion on certain important but less discussed endocrine and metabolic effects of modern sulfonylureas (SUs) and their usage in the management of diabetes mellitus (DM). BACKGROUND: Modern SUs may be considered a panacea in DM care with their beneficial extra-pancreatic, pleiotropic, and cardiovascular effects. Safe glycemic control with SUs could be achieved with appropriate patient selection, drug and dosage selection, and patient empowerment. Additionally, sulfonylureas also exhibit certain endocrine and metabolic effects, which could be considered beneficial in the management of DM. In this regard, a group of international clinical experts discussed the less known beneficial aspects of SUs and safe and smart prescription of modern SUs in DM care. RESULTS: The concept of glucocrinology or the relationship of glycemia with the endocrine system was emphasized during the meetings. Clinical experts arrived at a consensus for the usage of modern SUs in the presence of other endocrine dysfunction and the impact of these drugs on endocrine health. The beneficial pleiotropic and cardiovascular effects of modern SUs were also discussed. The key discussion points were considered to develop clinical expert opinions for the use of modern SUs in persons with DM. Clinical expert opinions were developed for indications, pleiotropic benefits, cardiovascular outcomes, adherence, and safe use of modern SUs. CONCLUSIONS: Appropriate clinical judgement coupled with a patient-centered approach is crucial to achieve the best outcome in persons with DM. Owing to their safety, efficacy, extra-pancreatic benefits including effects on endocrine and metabolic aspects, and low cost of therapy, modern SUs could be considered as drugs/agents of choice for the treatment of diabetes. FUNDING: Sanofi India.
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AIM: To develop an evidence-based expert group opinion on various types of euthymia associated with diabetes mellitus (DM) and its management. BACKGROUND: Diabetes mellitus is a metabolic syndrome characterized by diverse biomedical and psychosocial features. Emotional health disturbances may lead to psychological and psychiatric dysfunction and may negatively influence glycemic control. Patients with DM may experience diabetes distress (DD) associated with burden of self-care, interpersonal issues, and emotional worries regarding the ability to cope with the illness. Euthymia or a state of positive mental health and psychological well-being should be considered a key outcome of diabetes care. Therefore, to achieve optimal outcomes, the consideration and measurement of psychological and psychiatric aspects along with glycemic levels are very important. A group of multidisciplinary clinical experts came together in an international meeting held in India to develop a workable concept for euthymia in diabetes care. A multidisciplinary approach was suggested to enhance the clinical outcomes and facilitate patient-centered care. During the meeting emphasis was given to the concept of a euthymia model in diabetes care. This model focuses on enhancement of self-care skills in diabetic patients and preventative health awareness among diabetes care providers. Euthymia also encompasses patient-provider communication to aid enhancement of coping skills. RESULTS: After due discussions and extensive deliberations, the expert group provided several recommendations on implementing the concept of euthymia in DM care. CONCLUSIONS: Introduction of the concept of euthymia in routine clinical practice is important to improve the quality of life and coping skills in patients with DM. A timely clinical assessment of psychological and psychiatric aspects along with patient-reported outcomes of diabetes contributes to overall health and well-being of affected individuals. FUNDING: Sanofi India.
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The past three decades have seen a quadruple rise in the number of people affected by diabetes mellitus worldwide, with the disease being the ninth major cause of mortality. Type 2 diabetes mellitus (T2DM) often remains undiagnosed for several years due to its asymptomatic nature during the initial stages. In India, 70% of diagnosed diabetes cases remain uncontrolled. Current guidelines endorse the initiation of insulin early in the course of the disease, specifically in patients with HbA1c > 10%, as the use of oral agents alone is unlikely to achieve glycemic targets. Early insulin initiation and optimization of glycemic control using insulin titration algorithms and patient empowerment can facilitate the effective management of uncontrolled diabetes. Early glucose control has sustained benefits in people with diabetes. However, insulin initiation, dose adjustment, and the need to repeatedly assess blood glucose levels are often perplexing for both physicians and patients, and there are misconceptions and concerns regarding its use. Hence, an early transition to insulin and ideal intensification of treatment may aid in delaying the onset of diabetes complications. This opinion statement was formulated by an expert panel on the basis of existing guidelines, clinical experience, and economic and cultural contexts. The statement stresses the timely and appropriate use of basal insulin in T2DM. It focuses on the seven vital Ts-treatment initiation, timing of administration, transportation and storage, technique of administration, targets for titration, tablets, and tools for monitoring.Funding: Sanofi.
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The cationic surfactants assisted ultrasound route was used to prepare Dy3+ doped Zn2SiO4 nanophosphors. The final products were characterized by powder X-ray diffraction (PXRD), ultraviolet visible spectroscopy, scanning electron microscopy, transmission electron microscopy and photoluminescence. Orthorhombic phase of Zn2SiO4:Dy3+ (JCPDS card No. 35-1485) was confirmed from PXRD. It was evident that the morphology of spherical and broom like structures were obtained with epigallocatechin gallate (EGCG) and cetyltrimethylammonium bromide (CTAB) surfactants respectively. Further the size and agglomeration of the products were varied with surfactants concentration, sonication time, pH and sonication power. The probable formation mechanisms to obtain various micro/nano superstructures were discussed. The characteristic PL peaks were observed at 484, 574 and 666nm due to the electronic transitions 4F9/2â6Hj (j=15/2, 13/2, 11/2) of Dy3+ ions upon excited at NUV pumping wavelength of 350nm [6H15/2â6P7/2 (4M15/2)]. The Judd-Ofelt intensity parameters and radiative properties were estimated by using PL emission data. The photometric studies indicated that the obtained phosphors could be promising materials in white light emitting diodes (wLED's). The present synthesis route was rapid, environmentally benign, cost-effective and useful for industrial applications such as solid state lighting and display devices.
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A novel Sr2SiO4:Eu (1-5mol %) superstructures (SS) were synthesized using bio-sacrificial A.V. gel assisted ultrasound method. Powder X-ray diffraction patterns confirmed the presence of both α and ß phase formation. It was evident that the morphological growth was highly reliant on A.V. gel concentration, sonication time, pH and sonication power. The formation mechanisms for different hierarchical SS were proposed. From diffuse reflectance spectra, the energy band gap was estimated and found to be â¼4.70-5.11eV. The photoluminescence emission spectra for the excitation at 392nm, shows characteristic emission peaks at 593, 613, 654 and 702nm which were attributed to 5D0â7F0, 7F1,7F2 and 7F3 transitions of Eu3+ ions respectively. Conversely, when the samples were subjected to the heat treatment at 850°C for 3h under argon atmosphere, display an intense broad emission peak with two de-convoluted peaks at 490 and 550nm due to 4f65d1â4f1 (8S7/2) transitions of Eu2+ ions. The concentration quenching phenomenon was discussed which attributes to energy transfer, electron-phonon coupling and ion-ion interaction. The Judd-Ofelt intensity parameters and other radiative properties were estimated by using emission spectra. The CIE chromaticity coordinate values of Sr2SiO4:Eu2+ and Eu3+ nanophosphors were located in green and red regions respectively. The calculated CCT and CRI values specify that the present phosphor can be fairly useful for both green and red components of white LED's. Luminescence decay and quantum yield suggest the suitability of this phosphor as an efficient luminescent medium for light emitting diodes. Overall, the results elucidated a rapid, environmentally benign, cost-effective and convenient method for Sr2SiO4:Eu3+ synthesis and for the possible applications such as solid state lighting and display devices.
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Európio/química , Raio , Luminescência , Estrôncio/química , Ondas Ultrassônicas , Cor , Óxidos/químicaRESUMO
Diabetes remains asymptomatic for a long period of time and its real burden gets noticed only once the complications set in. The number of individuals affected with the disease is also on the rise and more so in the low income countries. This scenario calls for urgent precautionary measures that need to be undertaken to equip ourselves to fight against this chronic disease. Individuals with financial constraints cannot afford to access even the basic treatment facilities and thus stands the most burdened. The International Diabetes Federation calls for 'Eyes on Diabetes' for the society to focus on early screening and early intervention. The rising cost of diabetes results from delayed and denied treatment. The panel discussion organized as a part of 4th Annual global diabetes convention of Jothydev's Professional Education Forum (JPEF, 2016) facilitated a platform to address diabetes as a serious health concern that needs to be given immediate priority by the policymakers as well as public and also to discuss about the feasible measures that will help achieve cost effective and affordable diabetes treatment. This was followed by in-depth literature search and finally a set of recommendations have been arrived at by the key opinion leaders to realize the dream of affordable diabetes care to all deserving individuals.
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Redução de Custos/métodos , Diabetes Mellitus/economia , Gerenciamento Clínico , Efeitos Psicossociais da Doença , Diabetes Mellitus/terapia , HumanosRESUMO
About 12 glycosides prepared through amyloglucosidase catalysis and 23 amino acyl esters of carbohydrates prepared through lipase catalysis in organic solvents showed angiotensin converting enzyme (ACE) inhibition activity. Both amino acyl esters of carbohydrates and glycosides exhibited IC50 values for ACE inhibition in the 0.5 mM to 15.7 mM range. Eugenyl-D-glucoside (IC50: 0.5+/-0.04 mM), L-isoleucyl-D-glucose (IC50: 0.7+/-0.067 mM), vanillyl-D-sorbitol (IC50: 0.8+/-0.09 mM), L-histidyl-D-fructose (IC50: 0.9+/-0.087 mM), L-tryptophanyl-D-fructose (IC50: 0.9+/-0.092 mM), octyl-D-glucoside (IC50: 1.0+/-0.093 mM), vanillyl-D-mannoside (IC50: 1.0+/-0.089 mM), L-valyl-D-mannitol (IC50: 1.0+/-0.092 mM) and L-phenylalanyl-D-glucose (IC50: 1.0+/-0.089 mM) were the compounds, which showed the best ACE inhibitory activities.
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Inibidores da Enzima Conversora de Angiotensina/química , Inibidores da Enzima Conversora de Angiotensina/farmacologia , Carboidratos/química , Carboidratos/farmacologia , Ésteres/química , Peptidil Dipeptidase A/metabolismo , Aminoacilação , Concentração Inibidora 50 , Estrutura Molecular , Relação Estrutura-AtividadeRESUMO
This paper reports for the first time ultrasound, EGCG assisted synthesis of pure and Eu(3+) (1-5mol%) activated Ca2SiO4 nanophosphors having self-assembled superstructures with high purity. The shape, size and morphology of the product were tuned by controlling influential parameters. It was found that morphology was highly dependent on EGCG concentration, sonication time, pH and sonication power. The probable formation mechanism for various hierarchical superstructures was proposed. The PL studies of Ca2SiO4:Eu(3+) phosphors can be effectively excited by the near ultraviolet (UV) (396nm) light and exhibited strong red emission around 613nm, which was attributed to the Eu(3+) ((5)D0â(7)F2) transition. The concentration quenching phenomenon was explained based on energy transfer between defect and Eu(3+) ions, electron-phonon coupling and Eu(3+)-Eu(3+) interaction. The Judd-Ofelt intensity parameters and radiative properties were estimated by using PL emission spectra. The photometric studies indicate that the obtained phosphors could be a promising red component for possible applications in the field of white light emitting diodes.