Detalhe da pesquisa
1.
Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides.
Nucleic Acids Res
; 51(10): 4713-4725, 2023 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37099382
2.
PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [18F]PF-06684511.
Eur J Nucl Med Mol Imaging
; 47(10): 2429-2439, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32140803
3.
Dihedral Angle-Based Sampling of Natural Product Polyketide Conformations: Application to Permeability Prediction.
J Chem Inf Model
; 56(11): 2194-2206, 2016 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27731994
4.
Design, synthesis and evaluation of [(3)H]PF-7191, a highly specific nociceptin opioid peptide (NOP) receptor radiotracer for in vivo receptor occupancy (RO) studies.
Bioorg Med Chem Lett
; 24(22): 5219-23, 2014 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25442316
5.
Borrelidin B: isolation, biological activity, and implications for nitrile biosynthesis.
J Nat Prod
; 77(11): 2570-4, 2014 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25393949
6.
Dopamine D1 Receptor Agonist PET Tracer Development: Assessment in Nonhuman Primates.
J Nucl Med
; 62(9): 1307-1313, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33579806
7.
Quantitative Analysis of 18F-PF-06684511, a Novel PET Radioligand for Selective ß-Secretase 1 Imaging, in Nonhuman Primate Brain.
J Nucl Med
; 60(7): 992-997, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-30530832
8.
Author Correction: Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs.
Sci Rep
; 9(1): 6076, 2019 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30967561
9.
Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity.
J Med Chem
; 62(18): 8532-8543, 2019 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31483137
10.
Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs.
Sci Rep
; 8(1): 897, 2018 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29343833
11.
Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging ß-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain.
J Med Chem
; 61(8): 3296-3308, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29356535
12.
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, ß-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
J Med Chem
; 61(10): 4476-4504, 2018 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29613789
13.
Strategies to facilitate the discovery of novel CNS PET ligands.
EJNMMI Radiopharm Chem
; 1(1): 13, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29564389
14.
The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging.
J Med Chem
; 60(20): 8538-8551, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28957634
15.
Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery.
ACS Chem Neurosci
; 7(6): 767-75, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26991242
16.
Preclinical Evaluation of 18F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme.
J Nucl Med
; 57(9): 1448-53, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27199356
17.
Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure.
J Med Chem
; 47(6): 1575-86, 2004 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-14998342
18.
Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease.
Eur J Pharmacol
; 486(1): 9-17, 2004 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-14751402
19.
Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand.
J Med Chem
; 56(11): 4568-79, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23651455
20.
The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH).
Nucl Med Biol
; 39(7): 1058-67, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22571907