Detalhe da pesquisa
1.
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Cell
; 182(4): 1009-1026.e29, 2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32730809
2.
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.
Cell
; 171(3): 696-709.e23, 2017 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28965760
3.
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor.
Nat Chem Biol
; 19(7): 815-824, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36823351
4.
Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes.
J Am Chem Soc
; 146(1): 62-67, 2024 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38134034
5.
Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1.
J Am Chem Soc
; 144(40): 18688-18699, 2022 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36170674
6.
Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4-MyD88 Complex.
J Immunol
; 202(9): 2737-2746, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30885957
7.
Organometallic palladium reagents for cysteine bioconjugation.
Nature
; 526(7575): 687-91, 2015 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26511579
8.
2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles.
J Am Chem Soc
; 142(19): 8972-8979, 2020 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32302104
9.
A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex.
Angew Chem Int Ed Engl
; 59(10): 3896-3899, 2020 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31863675
10.
Arylation Chemistry for Bioconjugation.
Angew Chem Int Ed Engl
; 58(15): 4810-4839, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30399206
11.
The Proteome-Wide Potential for Reversible Covalency at Cysteine.
Angew Chem Int Ed Engl
; 58(33): 11385-11389, 2019 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31222866
12.
Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes.
J Am Chem Soc
; 140(26): 8069-8073, 2018 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29894184
13.
Correction to "Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1".
J Am Chem Soc
; 145(23): 12948, 2023 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37268298
14.
Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ.
Bioorg Med Chem Lett
; 28(16): 2682-2687, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29731364
15.
Design of New Ligands for the Palladium-Catalyzed Arylation of α-Branched Secondary Amines.
Angew Chem Int Ed Engl
; 54(28): 8259-62, 2015 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26032920
16.
Structural reevaluation of the electrophilic hypervalent iodine reagent for trifluoromethylthiolation supported by the crystalline sponge method for X-ray analysis.
Angew Chem Int Ed Engl
; 53(12): 3125-8, 2014 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24677728
17.
Covalent Targeting of Splicing in T Cells.
bioRxiv
; 2023 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38187674
18.
Using a function-first 'scout fragment'-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes.
bioRxiv
; 2023 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37808863
19.
Autoregulatory control of mitochondrial glutathione homeostasis.
Science
; 382(6672): 820-828, 2023 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37917749
20.
Palladium-catalyzed cross-coupling of aryl chlorides and triflates with sodium cyanate: a practical synthesis of unsymmetrical ureas.
J Am Chem Soc
; 134(27): 11132-5, 2012 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22716197