Detalhe da pesquisa
1.
Distinct biological events generated by ECM proteolysis by two homologous collagenases.
Proc Natl Acad Sci U S A
; 113(39): 10884-9, 2016 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27630193
2.
Effects of flexibility of the α2 chain of type I collagen on collagenase cleavage.
J Struct Biol
; 203(3): 247-254, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29763735
3.
Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.
J Biol Chem
; 291(42): 22160-22172, 2016 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27582494
4.
The recognition of collagen and triple-helical toolkit peptides by MMP-13: sequence specificity for binding and cleavage.
J Biol Chem
; 289(35): 24091-101, 2014 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-25008319
5.
Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1.
Proc Natl Acad Sci U S A
; 109(31): 12461-6, 2012 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22761315
6.
Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain.
FASEB J
; 27(11): 4395-405, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23913860
7.
Defining requirements for collagenase cleavage in collagen type III using a bacterial collagen system.
J Biol Chem
; 287(27): 22988-97, 2012 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22573319
8.
The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions.
J Biol Chem
; 286(9): 7587-600, 2011 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21193411
9.
Molecular mechanism of type I collagen homotrimer resistance to mammalian collagenases.
J Biol Chem
; 285(29): 22276-81, 2010 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20463013
10.
Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications.
Biochem J
; 431(1): 113-22, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20645923
11.
Crystal structure of an active form of human MMP-1.
J Mol Biol
; 362(1): 78-88, 2006 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-16890240
12.
Structure and function of matrix metalloproteinases and TIMPs.
Cardiovasc Res
; 69(3): 562-73, 2006 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16405877
13.
Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.
Circ Res
; 92(8): 827-39, 2003 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-12730128
14.
MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.
Matrix Biol
; 56: 57-73, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27084377
15.
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization.
Eur J Med Chem
; 47(1): 143-52, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22088955
16.
Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion.
Cancer Res
; 70(11): 4366-74, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20460529
17.
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
J Med Chem
; 52(15): 4757-73, 2009 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19606871
18.
Catalytic properties of ADAM12 and its domain deletion mutants.
Biochemistry
; 47(2): 537-47, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18081311
19.
The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity.
J Biol Chem
; 281(50): 38302-13, 2006 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17065155
20.
X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding.
J Biol Chem
; 280(10): 9578-85, 2005 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-15611040