Detalhe da pesquisa
1.
Xenografted Tumors Share Comparable Fraction Unbound and Can Be Surrogated by Mouse Lung Tissue.
Drug Metab Dispos
; 2024 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38670798
2.
Absorption, Distribution, Metabolism, and Excretion of [14C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism.
Drug Metab Dispos
; 50(5): 600-612, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35153196
3.
Pharmacokinetics, Disposition, and Biotransformation of [14C]Omecamtiv Mecarbil in Healthy Male Subjects after a Single Intravenous or Oral Dose.
Drug Metab Dispos
; 49(8): 619-628, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34011533
4.
Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat.
Toxicol Appl Pharmacol
; 423: 115578, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34004237
5.
Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking.
Mult Scler
; 27(7): 1014-1026, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32729352
6.
Nonclinical Safety Profile of Sotorasib, a KRASG12C-Specific Covalent Inhibitor for the Treatment of KRAS p.G12C-Mutated Cancer.
Int J Toxicol
; 40(5): 427-441, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34137282
7.
Strain-Dependent Variability of Early Discovery Small Molecule Pharmacokinetics in Mice: Does Strain Matter?
Drug Metab Dispos
; 48(8): 613-621, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32474442
8.
Approach for Identifying Human Leukocyte Antigen (HLA)-DR Bound Peptides from Scarce Clinical Samples.
Mol Cell Proteomics
; 15(9): 3017-29, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27452731
9.
T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis.
Clin Immunol
; 169: 114-120, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27339331
10.
T-cell receptor-HLA-DRB1 associations suggest specific antigens in pulmonary sarcoidosis.
Eur Respir J
; 47(3): 898-909, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26585430
11.
Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective.
Drug Metab Dispos
; 44(8): 1399-423, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27052879
12.
T cell receptor-Vß repertoires in lung and blood CD4+ and CD8+ T cells of pulmonary sarcoidosis patients.
BMC Pulm Med
; 14: 50, 2014 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24656074
13.
Tolerability and efficacy of the monoaminergic stabilizer (-)-OSU6162 (PNU-96391A) in Huntington's disease: a double-blind cross-over study.
Acta Neuropsychiatr
; 26(5): 298-306, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25241758
14.
Impact of Sotorasib on the Pharmacokinetics and Pharmacodynamics of Metformin, a MATE1/2K Substrate, in Healthy Subjects.
Clin Pharmacokinet
; 62(2): 267-275, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36529835
15.
Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration-QTc analysis.
Clin Transl Sci
; 16(3): 436-446, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36369797
16.
Antigen-specific multifunctional T-cells in sarcoidosis patients with Lofgren's syndrome.
Eur Respir J
; 40(1): 110-21, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22183480
17.
Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition.
Drug Metab Dispos
; 40(1): 47-53, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21976621
18.
Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors.
Drug Metab Dispos
; 40(12): 2239-49, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22930276
19.
Absorption, metabolism and excretion of [14C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate.
Cancer Chemother Pharmacol
; 90(4): 357-367, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36063185
20.
Evaluation of CYP2C8 inhibition in vitro: utility of montelukast as a selective CYP2C8 probe substrate.
Drug Metab Dispos
; 39(9): 1546-54, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21697463