Detalhe da pesquisa
1.
Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists.
Bioorg Med Chem Lett
; 22(6): 2167-71, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22361135
2.
Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers.
Amino Acids
; 40(2): 371-80, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20577889
3.
5-(2'-Pyridyl)-2-aminothiazoles: alkyl amino sulfonamides and sulfamides as potent NPY(5) antagonists.
Bioorg Med Chem Lett
; 21(21): 6500-4, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21924902
4.
Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.
Bioorg Med Chem Lett
; 21(18): 5436-41, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21782428
5.
N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists.
Bioorg Med Chem Lett
; 21(18): 5573-6, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21782430
6.
The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.
J Pharmacol Exp Ther
; 328(3): 900-11, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19098165
7.
3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.
J Med Chem
; 49(13): 3757-8, 2006 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16789730
8.
Use of Caenorhabditis elegans G{alpha}q chimeras to detect G-protein-coupled receptor signals.
J Biomol Screen
; 10(2): 127-36, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15799956
9.
Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility.
Bioorg Med Chem Lett
; 16(15): 3950-4, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16730981
10.
Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.
Proc Natl Acad Sci U S A
; 102(48): 17489-94, 2005 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16287967
11.
High-throughput synthesis optimization of sulfonamide NPY Y5 antagonists.
Bioorg Med Chem Lett
; 12(13): 1771-4, 2002 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-12067558
12.
Discovery of potent and selective small molecule NPY Y5 receptor antagonists.
Bioorg Med Chem Lett
; 12(13): 1767-9, 2002 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-12067557