1.
J Org Chem
; 76(2): 744-7, 2011 Jan 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21182271
RESUMO
A mild, metal-free, and environmently benign iodine-promoted regioselective C-C and C-N bonds formation of N-protected indole derivatives giving 2,3'-biindoles 2 and 4-(1H-indol-2-yl)morpholines 4 is successfully demonstrated. Various bioactive 2,3'-biindoles and 4-(1H-indol-2-yl)morpholines, bearing electron-rich to moderately electron-poor substituents, can be prepared in moderate to good yields.
Assuntos
Indóis/química , Iodo/química , Morfolinas/química , Espectroscopia de Ressonância Magnética , Modelos Moleculares , Estrutura Molecular , Estereoisomerismo
2.
Chem Commun (Camb)
; 48(17): 2343-5, 2012 Feb 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22262372
RESUMO
Highly substituted 2-aminated indoles can be prepared in moderate to excellent yields by regioselective C2-amination of indoles promoted by iodine. As a key step in a concise synthesis of (±)-folicanthine, its core structure was easily obtained by one step cyclization-dimerization of substituted tryptophan in high yield on a gram scale.