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1.
World J Surg Oncol ; 22(1): 262, 2024 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-39350212

RESUMO

OBJECTIVE: This study sought to explore the efficiency of para-aortic and pelvic lymphadenectomy in the treatment of locally advanced cervical cancer (LACC) with pelvic lymph node (PLN) metastasis. METHODS: A total of 171 LACC patients with imaging-confirmed pelvic lymph node metastasis were included in this study. These patients were divided into two groups: the surgical staging group, comprising 58 patients who had received para-aortic and pelvic lymphadenectomy (surgical staging) along with concurrent chemoradiation therapy (CCRT), and the imaging staging group, comprising 113 patients who had received only CCRT. The two groups' progression-free survival (PFS), overall survival (OS) and treatment-related complications were compared. RESULTS: The surgical staging group started radiotherapy 10.2 days (range 9-12 days) later than the imaging staging group. The overall incidence of lymphatic cysts was 9.30%. In the surgical staging group, para-aortic lymph node metastasis was identified in 34.48% (20/58) of patients, while pathology-negative PLN was observed in 12.07% (7/58). Over a median follow-up period of 52 months, no significant differences in PFS and OS rates were found between the two groups (p > 0.05). Subgroup analysis of patients with lymph node diameters of ≥ 1.5 cm revealed a five-year PFS rate of 75.0% and an OS rate of 80.0% in the surgical staging group, compared to 41.5% and 50.1% in the imaging staging group, respectively, showing statistically significant differences (p = 0.022, HR:0.34 [0.13, 0.90] and p = 0.038, HR: 0.34 [0.12,0.94], respectively for PFS and OS). Additionally, in patients with two or more metastatic lymph nodes, the five-year PFS and OS rates were 69.2% and 73.1% in the surgical staging group, versus 41.0% and 48.4% in the imaging staging group, with these differences also being statistically significant (p = 0.025, HR: 0.41[0.19,0.93] and p = 0.046, HR: 0.42[0.18,0.98], respectively). CONCLUSION: Performing surgical staging before CCRT is safe and delivers accurate lymph node details crucial for tailoring radiotherapy. This approach merits further investigation, particularly in women with pelvic lymph nodes measuring 1.5 cm or more in diameter or patients with two or more imaging-positive PLNs.


Assuntos
Excisão de Linfonodo , Linfonodos , Metástase Linfática , Pelve , Neoplasias do Colo do Útero , Humanos , Feminino , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/cirurgia , Neoplasias do Colo do Útero/terapia , Neoplasias do Colo do Útero/mortalidade , Excisão de Linfonodo/métodos , Pessoa de Meia-Idade , Adulto , Seguimentos , Taxa de Sobrevida , Linfonodos/patologia , Linfonodos/cirurgia , Pelve/patologia , Pelve/cirurgia , Prognóstico , Idoso , Estudos Retrospectivos , Quimiorradioterapia/métodos , Estadiamento de Neoplasias , Aorta/patologia , Aorta/cirurgia , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/cirurgia , Carcinoma de Células Escamosas/terapia , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/secundário
2.
Blood Press Monit ; 26(5): 396-399, 2021 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-34480474

RESUMO

OBJECTIVE: To evaluate the accuracy of the YuWell YE900 oscillometric upper-arm professional office blood pressure monitor in adults and children according to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO) Universal Standard (ISO 81060-2:2018). METHODS: Subjects were recruited to fulfill the age, sex, blood pressure and cuff distribution criteria of the AAMI/ESH/ISO Universal Standard in adults and children (aged 3-12 years) using the same arm sequential blood pressure measurement method. Three cuffs of the test device were used for arm circumference 18-22 cm (small), 22-32 cm (medium) and 32-42 cm (large). RESULTS: Ninety-two subjects were recruited, and 85 (50 adults and 35 children) were analyzed. For validation criterion 1, the mean ± SD of the differences between the test device and reference blood pressure readings was 1.7 ± 6.62/3.1 ± 5.76 mmHg (systolic/diastolic). For validation criterion 2, the SD of the averaged blood pressure differences between the test device and reference blood pressure per subject was 5.25/5.13 mmHg (systolic/diastolic). CONCLUSION: The YuWell YE900 professional electronic blood pressure monitor has passed the requirements of the AAMI/ESH/ISO Universal Standard (ISO 81060-2:2018) in adults and children and can be recommended for clinical use.


Assuntos
Determinação da Pressão Arterial , Monitores de Pressão Arterial , Adulto , Pressão Sanguínea , Criança , Pré-Escolar , Humanos , Esfigmomanômetros , Sístole
3.
J Zhejiang Univ Sci B ; 21(7): 571-580, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32633111

RESUMO

To reduce the problems of poor solubility, high in vivo dosage requirement, and weak targeting ability of paclitaxel (PTX), a hyaluronic acid-octadecylamine (HA-ODA)-modified nano-structured lipid carrier (HA-NLC) was constructed. HA-ODA conjugates were synthesized by an amide reaction between HA and ODA. The hydrophobic chain of HA-ODA can be embedded in the lipid core of the NLC to obtain HA-NLC. The HA-NLC displayed strong internalization in cluster determinant 44 (CD44) highly expressed MCF-7 cells, and endocytosis mediated by the CD44 receptor was involved. The HA-NLC had an encapsulation efficiency of PTX of 72.0%. The cytotoxicity of the PTX-loaded nanoparticle HA-NLC/PTX in MCF-7 cells was much stronger than that of the commercial preparation Taxol®. In vivo, the HA-NLC exhibited strong tumor targeting ability. The distribution of the NLCs to the liver and spleen was reduced after HA modification, while more nanoparticles were aggregated to the tumor site. Our results suggest that HA-NLC has excellent properties as a nano drug carrier and potential for in vivo targeting.


Assuntos
Aminas/administração & dosagem , Sistemas de Liberação de Medicamentos , Ácido Hialurônico/análogos & derivados , Nanopartículas/administração & dosagem , Neoplasias/tratamento farmacológico , Paclitaxel/administração & dosagem , Animais , Endocitose , Feminino , Humanos , Ácido Hialurônico/administração & dosagem , Ácido Hialurônico/química , Ácido Hialurônico/farmacocinética , Lipídeos/química , Células MCF-7 , Camundongos , Camundongos Endogâmicos BALB C , Nanopartículas/química
4.
Sci Rep ; 5: 11246, 2015 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-26084812

RESUMO

Empirical results indicate that inducible defenses of plants have effects on herbivore populations. However, little is known about how inducible defenses of plants have influences on herbivore outbreak when space effect is considered. To reveal the relationship between inducible defenses and herbivore outbreak, we present a mathematical model to describe the interaction of them. It was found that time delay plays dual effects in the persistence of herbivore populations: (i) large value of time delay may be associated with small density of herbivore populations, and thus causes the populations to run a higher risk of extinction; (ii) moderate value of time delay is beneficial for maintaining herbivore density in a determined range which may promote the persistence of herbivore populations. Additionally, we revealed that interaction of time delay and space promotes the growth of average density of herbivore populations during their outbreak period which implied that time delay may drive the resilience of herbivore populations. Our findings highlight the close relationship between inducible defenses of plants and herbivore outbreak.


Assuntos
Ecossistema , Herbivoria , Plantas , Algoritmos , Animais , Cadeia Alimentar , Modelos Teóricos
5.
Gene ; 534(2): 324-44, 2014 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-24498651

RESUMO

T3801C is a common polymorphism in CYP1A1, showing differences in its biological functions. Case-control studies have been performed to elucidate the role of T3801C in cancer, although the results are conflicting and heterogeneous. Hence, we performed a meta-analysis to investigate the association between cancer susceptibility and T3801C (55,963 cases and 76,631 controls from 268 studies) polymorphism in different inheritance models.We used odds ratios with 95% confidence intervals to assess the strength of the association. Overall, significantly increased cancer risk was observed in any genetic model (dominant model: odds ratio [OR]=1.14, 95% confidence interval [CI]=1.09­1.19; recessive model: OR=1.23, 95% CI=1.12­1.34; CC vs. TT: OR=1.31, 95% CI=1.19­1.45; TC vs. TT: OR=1.12, 95% CI=1.07­1.18; additive model: OR=1.14, 95% CI=1.09­1.19) when all eligible studies were pooled into the meta-analysis. In further stratified and sensitivity analyses, the elevated risk remained for subgroups of cervical cancer, head and neck cancer, hepatocellular cancer, leukemia, lung cancer, prostate cancer and breast cancer. In addition, significantly decreased colorectal cancer risk was also observed. In summary, this meta-analysis suggests that the participation of CYP1A1 T3801C is a genetic susceptibility for some cancer types.Moreover, our work also points out the importance of new studies for T3801C association in some cancer types, such as gallbladder cancer, Asians of acute myeloid leukemia, and thyroid cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the CYP1A1 T3801C polymorphism in cancer development.


Assuntos
Citocromo P-450 CYP1A1/genética , Neoplasias/enzimologia , Neoplasias/genética , Estudos de Casos e Controles , Intervalos de Confiança , Feminino , Predisposição Genética para Doença , Genótipo , Humanos , Masculino , Razão de Chances , Polimorfismo Genético , Risco , Fatores de Risco
6.
PLoS One ; 9(5): e88490, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24802942

RESUMO

BACKGROUND: The XPG (xeroderma pigmentosum type G) Asp1104His and XPF (xeroderma pigmentosum type F) Arg415Gln polymorphisms had been implicated in cancer susceptibility. The previous published data on the association between XPG Asp1104His and XPF Arg415Gln polymorphisms and cancer risk remained controversial. METHODOLOGY/PRINCIPAL FINDINGS: To derive a more precise estimation of the association between the XPG Asp1104His and XPF Arg415Gln polymorphisms and overall cancer risk, we performed a meta-analysis to investigate the association between cancer susceptibility and XPG Asp1104His (32,162 cases and 39,858 controls from 66 studies) and XPF Arg415Gln polymorphisms (17,864 cases and 20,578 controls from 32 studies) in different inheritance models. We used odds ratios with 95% confidence intervals to assess the strength of the association. Overall, significantly elevated cancer risk was found when all studies were pooled into the meta-analysis of XPG Asp1104His (dominant model: OR = 1.05, 95% CI = 1.00-1.10; Asp/His vs. Asp/Asp: OR = 1.06, 95% CI = 1.01-1.11). In the further stratified and sensitivity analyses, significantly decreased lung cancer risk was found for XPF Arg415Gln (dominant model: OR = 0.82, 95% CI = 0.71-0.96; Arg/Gln versus Arg/Arg: OR = 0.83, 95% CI = 0.71-0.97; additive model: OR = 0.83, 95% CI = 0.72-0.95) and significantly increased other cancer risk was found among hospital-based studies for XPG Asp1104His (dominant model: OR = 1.23, 95% CI = 1.02-1.49). CONCLUSIONS/SIGNIFICANCE: In summary, this meta-analysis suggests that XPF Arg415Gln polymorphism may be associated with decreased lung cancer risk and XPG Asp1104His may be a low-penetrant risk factor in some cancers development. And larger scale primary studies are required to further evaluate the interaction of XPG Asp1104His and XPF Arg415Gln polymorphisms and cancer risk in specific populations.


Assuntos
Proteínas de Ligação a DNA/genética , Endonucleases/genética , Neoplasias Pulmonares/genética , Mutação de Sentido Incorreto , Proteínas Nucleares/genética , Polimorfismo Genético , Fatores de Transcrição/genética , Estudos de Casos e Controles , Humanos
7.
Gene ; 523(1): 10-9, 2013 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-23562721

RESUMO

The T241M polymorphism in the X-ray cross-complementing group 3 (XRCC3) had been implicated in cancer susceptibility. The previous published data on the association between XRCC3 T241M polymorphism and cancer risk remained controversial. Hence, we performed a meta-analysis to investigate the association between cancer susceptibility and XRCC3 T241M (61,861 cases and 84,584 controls from 157 studies) polymorphism in different inheritance models. We used odds ratios with 95% confidence intervals to assess the strength of the association. Overall, significantly increased cancer risk was observed in any genetic model (dominant model: odds ration [OR]=1.07, 95% confidence interval [CI]=1.00-1.13; recessive model: OR=1.15, 95% CI=1.08-1.23; additive model: OR=1.17, 95% CI=1.08-1.28) when all eligible studies were pooled into the meta-analysis. In further stratified and sensitivity analyses, the elevated risk remained for subgroups of bladder cancer and breast cancer, especially in Caucasians. In addition, significantly decreased lung cancer risk was also observed. In summary, this meta-analysis suggests the participation of XRCC3 T241M in the susceptibility for bladder cancer and breast cancer, especially in Caucasians, and XRCC3 T241M polymorphism is associated with decreased lung cancer risk. Moreover, our work also points out the importance of new studies for T241M association in some cancer types, such as gastric cancer, colorectal cancer, and melanoma skin cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the XRCC3 polymorphism in cancer development.


Assuntos
Neoplasias da Mama/genética , Proteínas de Ligação a DNA/genética , Estudos de Associação Genética/métodos , Polimorfismo Genético , Neoplasias da Mama/etnologia , Estudos de Casos e Controles , Intervalos de Confiança , Bases de Dados Genéticas , Detecção Precoce de Câncer/métodos , Feminino , Predisposição Genética para Doença/etnologia , Predisposição Genética para Doença/genética , Geografia , Humanos , Neoplasias Pulmonares/etnologia , Neoplasias Pulmonares/genética , Razão de Chances , Fatores de Risco , Neoplasias da Bexiga Urinária/etnologia , Neoplasias da Bexiga Urinária/genética , População Branca/genética
8.
Huan Jing Ke Xue ; 33(6): 1923-9, 2012 Jun.
Artigo em Zh | MEDLINE | ID: mdl-22946177

RESUMO

Using sub-milliFiltration (SMF) module get the sludge of the system divide into high concentration part and low concentration part, in order to make the high concentration part retain activated sludge to strengthen removal rate of organics and the low concentration part meet the need of MBR. Discussing the sludge concentration partition effect under the conditions of small reflux ratio(R 0.5, 1.0, 1.5, 2.0), In addition, investigating the COD removal efficiency of the system with SMF Module, comparing the measured and theoretical value of the MLVSS at each small reflux ratio. Results show that: the method of sludge concentration partition at small reflux ratio condition is feasible, the MLSS of the low concentration part is below 9 g x L(-1) and the high concentration part is above 20 g x L(-1); average removal rate of COD is above 90%; measured value of the two part is related to theoretical value.


Assuntos
Reatores Biológicos , Esgotos/química , Eliminação de Resíduos Líquidos/métodos , Análise da Demanda Biológica de Oxigênio , Filtração/métodos , Membranas Artificiais , Compostos Orgânicos/isolamento & purificação , Projetos Piloto , Eliminação de Resíduos/métodos , Águas Residuárias/química
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