Detalhe da pesquisa
1.
BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir.
Antimicrob Agents Chemother
; 68(4): e0095623, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38446062
2.
Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis.
J Med Chem
; 64(13): 8992-9009, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34132534
3.
The crossed [2+2] cycloaddition of 1-phenylcyclopropene and 1-bromo-2-phenylcyclopropene.
J Org Chem
; 74(20): 7994-7, 2009 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19761203
4.
Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design.
Eur J Med Chem
; 124: 186-199, 2016 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-27573544
5.
Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation.
Oncotarget
; 7(52): 86239-86256, 2016 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27863392
6.
Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification.
Sci Rep
; 5: 11702, 2015 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26118648
7.
Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer.
Expert Opin Investig Drugs
; 23(10): 1333-48, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24921970
8.
Ligand efficiency based approach for efficient virtual screening of compound libraries.
Eur J Med Chem
; 83: 226-35, 2014 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24960626
9.
3D-QSAR-assisted drug design: identification of a potent quinazoline-based Aurora kinase inhibitor.
ChemMedChem
; 8(1): 136-48, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23172777
10.
A novel synthesis of calix[4]thiophenes and calix[4]furans.
Chem Commun (Camb)
; 46(27): 5009-11, 2010 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20523935