Detalhe da pesquisa
1.
QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model.
Breast Cancer Res
; 11(3): R25, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19409087
2.
Modulation of cancer cell survival pathways using multivalent liposomal therapeutic antibody constructs.
Mol Cancer Ther
; 6(3): 844-55, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17339368
3.
In Vivo Validation of PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target.
Clin Cancer Res
; 23(21): 6555-6566, 2017 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28790117
4.
HER-2/neu overexpression increases the viable hypoxic cell population within solid tumors without causing changes in tumor vascularization.
Mol Cancer Res
; 2(11): 606-19, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15561777
5.
Treatment of HER-2/neu overexpressing breast cancer xenograft models with trastuzumab (Herceptin) and gefitinib (ZD1839): drug combination effects on tumor growth, HER-2/neu and epidermal growth factor receptor expression, and viable hypoxic cell fraction.
Clin Cancer Res
; 10(7): 2512-24, 2004 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15073131
6.
3'-Phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1) knockdown sensitizes non-small cell lung cancer cells to DNA damaging agents.
Oncotarget
; 6(19): 17161-77, 2015 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26220590
7.
Combined RNAi-mediated suppression of Rictor and EGFR resulted in complete tumor regression in an orthotopic glioblastoma tumor model.
PLoS One
; 8(3): e59597, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23555046
8.
Induction of autophagy is an early response to gefitinib and a potential therapeutic target in breast cancer.
PLoS One
; 8(10): e76503, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24146879
9.
Validating the use of a luciferase labeled breast cancer cell line, MDA435LCC6, as a means to monitor tumor progression and to assess the therapeutic activity of an established anticancer drug, docetaxel (Dt) alone or in combination with the ILK inhibitor, QLT0267.
Cancer Biol Ther
; 11(9): 826-38, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21358264
10.
Leishmania major abrogates gamma interferon-induced gene expression in human macrophages from a global perspective.
Infect Immun
; 75(7): 3506-15, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17470541
11.
Treatment with a cholesterol absorption inhibitor (FM-VP4) reduces body mass and adipose accumulation in developing and pre-obese mice.
Drug Dev Ind Pharm
; 33(10): 1058-69, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17963113
12.
Decreased levels of hypoxic cells in gefitinib treated ER+ HER-2 overexpressing MCF-7 breast cancer tumors are associated with hyperactivation of the mTOR pathway: therapeutic implications for combination therapy with rapamycin.
Breast Cancer Res Treat
; 106(3): 319-31, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17347776
13.
Development of a recombinant Leishmania major strain sensitive to ganciclovir and 5-fluorocytosine for use as a live vaccine challenge in clinical trials.
Vaccine
; 23(9): 1170-7, 2005 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15629360