Detalhe da pesquisa
1.
Evaluation of a TGN1412 analogue using in vitro assays and two immune humanized mouse models.
Toxicol Appl Pharmacol
; 372: 57-69, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30914376
2.
Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions.
Part Fibre Toxicol
; 14(1): 25, 2017 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28716104
3.
Nonclinical evaluation of the potential for mast cell activation by an erythropoietin analog.
Toxicol Appl Pharmacol
; 287(3): 246-52, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26079829
4.
Scientific and Regulatory Policy Committee Points-to-consider Paper*: Drug-induced Vascular Injury Associated with Nonsmall Molecule Therapeutics in Preclinical Development: Part 2. Antisense Oligonucleotides.
Toxicol Pathol
; 43(7): 935-44, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25717082
5.
Scientific and Regulatory Policy Committee Points-to-consider Paper*: Drug-induced Vascular Injury Associated with Nonsmall Molecule Therapeutics in Preclinical Development: Part I. Biotherapeutics.
Toxicol Pathol
; 43(7): 915-34, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25722122
6.
The role of eNOS phosphorylation in causing drug-induced vascular injury.
Toxicol Pathol
; 42(4): 709-24, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24705881
7.
Nonclinical safety biomarkers of drug-induced vascular injury: current status and blueprint for the future.
Toxicol Pathol
; 42(4): 635-57, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24777748
8.
Considerations for Use of Pharmacodynamic Biomarkers to Support Biosimilar Development - (II) A Randomized Trial with IL-5 Antagonists.
Clin Pharmacol Ther
; 113(1): 80-89, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36184697
9.
A metagenomic analysis for combination therapy of multiple classes of antibiotics on the prevention of the spread of antibiotic-resistant genes.
Gut Microbes
; 15(2): 2271150, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37908118
10.
Considerations for Use of Pharmacodynamic Biomarkers to Support Biosimilar Development - (III) A Randomized Trial with Interferon Beta-1a Products.
Clin Pharmacol Ther
; 113(2): 339-348, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36324229
11.
Evaluating the Utility of Proteomics for the Identification of Circulating Pharmacodynamic Biomarkers of IFNß-1a Biologics.
Clin Pharmacol Ther
; 113(1): 98-107, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36308070
12.
Establishing the carcinogenic risk of immunomodulatory drugs.
Toxicol Pathol
; 40(2): 267-71, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22105649
13.
Evaluation of a Sequential Antibiotic Treatment Regimen of Ampicillin, Ciprofloxacin and Fosfomycin against Escherichia coli CFT073 in the Hollow Fiber Infection Model Compared with Simultaneous Combination Treatment.
Antibiotics (Basel)
; 11(12)2022 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36551362
14.
Expanding Approved Patient Populations for Rare Disease Treatment Using In Vitro Data.
Clin Pharmacol Ther
; 112(1): 58-61, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34496049
15.
Calibration and Validation of a Mechanistic COVID-19 Model for Translational Quantitative Systems Pharmacology - A Proof-of-Concept Model Development for Remdesivir.
Clin Pharmacol Ther
; 112(4): 882-891, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35694844
16.
New science, drug regulation, and emergent public health issues: The work of FDA's division of applied regulatory science.
Front Med (Lausanne)
; 9: 1109541, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36743666
17.
Anti-SARS-CoV-2 Repurposing Drug Database: Clinical Pharmacology Considerations.
CPT Pharmacometrics Syst Pharmacol
; 10(9): 973-982, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34218521
18.
Effects of sedative psychotropic drugs combined with oxycodone on respiratory depression in the rat.
Clin Transl Sci
; 14(6): 2208-2219, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34080766
19.
Early events in vascular injury in the rat induced by the phosphodiesterase IV inhibitor SCH 351591.
Toxicol Pathol
; 38(5): 738-44, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20585143
20.
Effect of drug combinations on the kinetics of antibiotic resistance emergence in Escherichia coli CFT073 using an in vitro hollow-fibre infection model.
Int J Antimicrob Agents
; 55(4): 105861, 2020 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-31838036