Sustained response to bevacizumab in a patient with mosaic neurofibromatosis type 2 carrying the NF2:c.784C>T p.(Arg262*) variant.

Neurofibromatosis type 2 (NF2) is a tumor predisposition syndrome characterized by the growth of schwannomas, especially bilateral vestibular schwannomas (VS), meningiomas, and ependymomas. The anti-VEGF antibody bevacizumab has shown efficacy for VS in some NF2 patients. However, there is limited data on the effect of bevacizumab on non-vestibular tumors, and on the correlation between therapy response and genotype. Here, we report on a 33-year-old patient with bilateral VS, 14 additional intracranial or spinal schwannomas, and a meningioma treated with bevacizumab, off-label in the European Union, for 2 years. The genotype of the patient was determined by mutational analysis of NF2, SMARCB1, and LZTR1 on DNA of multiple tissues. Additionally, we performed volumetric measurements of quantifiable non-vestibular tumors (n = 8) on MRI scans from 5 pre-therapeutic and 2 therapeutic years, and pure-tone audiometry of the non-deaf ear. A heterozygous NM_000268.3(NF2):c.784C>T p.(Arg262*) variant was identified in DNA from 3 schwannomas, but not in leukocyte or oral mucosa DNA, and no rare SMARCB1/LZTR1 variants were detected, establishing the diagnosis of definite NF2 mosaicism. While schwannomas had progressed with a mean annual growth rate of 38% pre-therapeutically, volume stabilization or reduction of all schwannomas along with improvement of pain and neurological deficits, including hearing impairment, were observed under 24 months of bevacizumab. In summary, this is the first report of a sustained response to bevacizumab in a patient shown to carry the frequent mosaic NF2:c.784C>T p.(Arg262*) variant. Our results may be of particular relevance to guide treatment decisions in mosaic NF2 patients harboring this variant.

Rare germline variants in the E-cadherin gene CDH1 are associated with the risk of brain tumors of neuroepithelial and epithelial origin.

The genetic basis of brain tumor development is poorly understood. Here, leukocyte DNA of 21 patients from 15 families with ≥ 2 glioma cases each was analyzed by whole-genome or targeted sequencing. As a result, we identified two families with rare germline variants, p.(A592T) or p.(A817V), in the E-cadherin gene CDH1 that co-segregate with the tumor phenotype, consisting primarily of oligodendrogliomas, WHO grade II/III, IDH-mutant, 1p/19q-codeleted (ODs). Rare CDH1 variants, previously shown to predispose to gastric and breast cancer, were significantly overrepresented in these glioma families (13.3%) versus controls (1.7%). In 68 individuals from 28 gastric cancer families with pathogenic CDH1 germline variants, brain tumors, including a pituitary adenoma, were observed in three cases (4.4%), a significantly higher prevalence than in the general population (0.2%). Furthermore, rare CDH1 variants were identified in tumor DNA of 6/99 (6%) ODs. CDH1 expression was detected in undifferentiated and differentiating oligodendroglial cells isolated from rat brain. Functional studies using CRISPR/Cas9-mediated knock-in or stably transfected cell models demonstrated that the identified CDH1 germline variants affect cell membrane expression, cell migration and aggregation. E-cadherin ectodomain containing variant p.(A592T) had an increased intramolecular flexibility in a molecular dynamics simulation model. E-cadherin harboring intracellular variant p.(A817V) showed reduced ß-catenin binding resulting in increased cytosolic and nuclear ß-catenin levels reverted by treatment with the MAPK interacting serine/threonine kinase 1 inhibitor CGP 57380. Our data provide evidence for a role of deactivating CDH1 variants in the risk and tumorigenesis of neuroepithelial and epithelial brain tumors, particularly ODs, possibly via WNT/ß-catenin signaling.

How to alleviate the agony of providing negative feedback: Emotion regulation strategies affect hormonal stress responses to a managerial task.

Providing negative feedback can be demanding, as it typically requires dealing with multiple negative emotions. The first aim of this study was to transfer this work-related task to a new laboratory protocol and to investigate short-term hormonal changes among feedback providers. The second aim was to test if such hormonal stress responses can be attenuated through a priori instructions on how to regulate emotions. Each of 150 participants (51% women) provided eight saliva samples before, during, and after anticipating and conducting a negative feedback conversation with a professional actor who displayed negative emotional reactions. Participants were divided into four conditions regarding the way they were instructed to regulate their emotions: expressive suppression (keeping a neutral expression); cognitive reappraisal (staying task-oriented and emotionally distanced); affect utilization (moving towards and using emotions); or control condition. By means of three-phase spline growth models, latent growth factors during baseline, stress response, and recovery were specified. Providing negative feedback was followed by significant temporary testosterone decreases as well as cortisol increases. Testosterone (but not cortisol) responses were attenuated when feedback providers had been instructed to either follow a cognitive reappraisal or affect utilization strategy. This study provides evidence that a typical managerial task, that is, having to provide negative feedback, is a testosterone- and cortisol-relevant experience. Down-regulation of an individual's emotional involvement through reappraisal, as well as the newly introduced technique of moving towards and making use of the interaction partner's emotions (affect utilization), revealed consequences in terms of attenuating the testosterone response to stress.

Primary and secondary gliosarcoma: differences in treatment and outcome.

INTRODUCTION: There are only few studies comparing differences in the outcome of primary versus secondary gliosarcoma. This study aimed to review the outcome and survival of patients with primary or secondary gliosarcoma following surgical resection and adjuvant treatment. The data were also matched with data of patients with primary and secondary glioblastoma (GBM). PATIENTS AND METHODS: Treatment histories of 10 patients with primary gliosarcoma and 10 patients with secondary gliosarcoma were analysed and compared. Additionally, data of 20 patients with primary and 20 patients with secondary GBM were analysed and compared. All patients underwent surgical resection of the tumour in our department. Follow-up data, progression-free survival (PFS), and median overall survival (mOS) were evaluated. RESULTS: The median PFS in patients with primary gliosarcoma was significantly higher than in patients with secondary gliosarcoma (p = 0.037). The 6-month PFS rates were 80.0% in patients with primary and 30.0% in patients with secondary gliosarcoma. Upon recurrence, five patients with primary gliosarcoma and four patients with secondary gliosarcoma underwent repeat surgical resection. The mOS of patients with primary gliosarcoma was significantly higher than that of patients with secondary gliosarcoma (p = 0.031). The percentage of patients surviving at 1-year/2-year follow-up in primary gliosarcoma was 70%/20%, while it was only 10%/10% in secondary gliosarcoma. When PFS and mOS of primary gliosarcoma was compared to primary GBM, there were no statistically differences (p = 0.509; p = 0.435). The PFS and mOS of secondary gliosarcoma and secondary GBM were also comparable (p = 0.290 and p = 0.390). CONCLUSION: Patients with primary gliosarcoma have a higher PFS and mOS compared to those with secondary gliosarcoma. In the case of tumour recurrence, patients with secondary gliosarcoma harbour an unfavourable prognosis with limited further options. The outcome of patients with primary or secondary gliosarcoma is comparable to that of patients with primary or secondary GBM.

Too hot to carry on? Disinclination to persist at a task in a warm office environment.

We investigated the effect of an elevated ambient temperature on performance in a persistence task. The task involved the coding of incorrect symbols and participants were free to decide how long to spend performing this task. Applying a between-subject design, we tested 125 students in an office-like environment in one of the three temperature conditions. The comfort condition (Predicted Mean Vote [PMV] = 0.01) featured an average air temperature of 24 °C. The elevated ambient temperature condition was 28 °C (PMV = 1.17). Condition three employed an airstream of approximately 0.8 m/s, intended to compensate for performance decrements at the elevated air temperature (28 °C, PMV = 0.13), according to Fanger's thermal comfort equation. Participants in the warm condition were significantly less persistent compared with participants in the control and compensation conditions. As predicted by the thermal comfort equation, the airstream seemed to compensate for the higher temperature. Participants' persistence in the compensation and comfort conditions did not differ. Practitioner Summary: A laboratory experiment involving a simulated office environment and three ambient temperature conditions (24 °C, 28 °C and 28 °C plus airstream) showed that persistence at a task is significantly impaired at 28 °C. An airstream of 0.8 m/s at 28 °C compensated for the disinclination to persist with the task.

Rare ADAR and RNASEH2B variants and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis.

In search of novel germline alterations predisposing to tumors, in particular to gliomas, we studied a family with two brothers affected by anaplastic gliomas, and their father and paternal great-uncle diagnosed with prostate carcinoma. In this family, whole-exome sequencing yielded rare, simultaneously heterozygous variants in the Aicardi-Goutières syndrome (AGS) genes ADAR and RNASEH2B co-segregating with the tumor phenotype. AGS is a genetically induced inflammatory disease particularly of the brain, which has not been associated with a consistently increased cancer risk to date. By targeted sequencing, we identified novel ADAR and RNASEH2B variants, and a 3- to 17-fold frequency increase of the AGS mutations ADAR,c.577C>G;p.(P193A) and RNASEH2B,c.529G>A;p.(A177T) in the germline of familial glioma patients as well as in test and validation cohorts of glioblastomas and prostate carcinomas versus ethnicity-matched controls, whereby rare RNASEH2B variants were significantly more frequent in familial glioma patients. Tumors with ADAR or RNASEH2B variants recapitulated features of AGS, such as calcification and increased type I interferon expression. Patients carrying ADAR or RNASEH2B variants showed upregulation of interferon-stimulated gene (ISG) transcripts in peripheral blood as seen in AGS. An increased ISG expression was also induced by ADAR and RNASEH2B variants in tumor cells and was blocked by the JAK inhibitor Ruxolitinib. Our data implicate rare variants in the AGS genes ADAR and RNASEH2B and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis, consistent with a genetic basis underlying inflammation-driven malignant transformation in glioma and prostate carcinoma development.

Multidomain engagement and self-reported psychosomatic symptoms in middle-aged women and men.

BACKGROUND: Multimorbidity can be operationalized as the presence of multiple psychosomatic symptoms and has been shown to be detrimental to the quality of life across the life span. Middle-aged adults are generally engaged in multiple life domains simultaneously. This is one of the developmental challenges of middle adulthood as it can lead to conflict between the demands of different domains and, in turn, contribute to multiple psychosomatic symptoms, thereby diminishing the quality of life. This may be particularly true for women. Facilitation between life domains may serve to reduce the number of psychosomatic symptoms. However, this subject has been largely neglected in the literature. OBJECTIVE: We aimed to close this gap by investigating the influence of conflict and facilitation between life domains (work, family, leisure) on self-reported psychosomatic symptoms in middle-aged women and men. METHODS: Life domain conflict/facilitation and psychosomatic symptoms were assessed via self-report in a cross-sectional study with 277 adults aged 30-55 years (mean = 41.70, SD = 7.2; 56.7% women) who all worked at least 30 h/week and lived with their partner or family. RESULTS: In line with our hypothesis, women reported more psychosomatic symptoms when they experienced conflict between life domains. However, contrary to expectation, they did not profit more from facilitation than men and, at low levels of facilitation, women even reported more psychosomatic symptoms than men. In men, there was no association between life domain conflict/facilitation and psychosomatic symptoms. The results were robust when statistically controlling for neuroticism. CONCLUSIONS: Engagement in multiple life domains influences the frequency of psychosomatic symptoms in women, but not in men: women suffer more and profit less than men from combining work, family and leisure.

Decision made, good feelings fade? How noise and multitasking affect decision confidence and well-being.

Objectives. This study aimed to examine the influence of office noise and multitasking on decision confidence, overconfidence, satisfaction, calibration and affective well-being. Detrimental effects of noise and multitasking on perceived annoyance and concentration are well documented. Little is known about whether decision confidence and well-being during decisions are also affected. Methods. The study was a between-subjects laboratory experiment (n = 109) involving a noise condition with office noise presented through headphones (A-weighted equivalent sound pressure level of LAeq = 60 dB), a multitasking condition with an email-sorting task as the primary task and a control condition. Results. Compared to the control condition, subjects in the noise and multitasking conditions exhibited overestimation of confidence. There was also a significant decrease in well-being for people in the noise condition. Calibration was not affected. Conclusion. In the case of noise, well-being is affected even before the thresholds of workplace legislation are reached. Undue overconfidence can have detrimental effects upon subsequent decisions and risk-taking. Findings suggest that there should be greater consideration of environmental influences during decision-making in work environments.

Dual-earner couples' sharing of work-related experiences: Effects on relational and personal well-being.

Personal growth and self-expressive goals have become increasingly important in modern marriages. In dual-earner couples, sharing work-related experiences with the partner can be particularly important in promoting mutual support for each other's personal growth. The current study examined dual-earner couples' sharing of work-related experiences and how it influenced both partners' relationship satisfaction and personal well-being. A total of 102 heterosexual dual-earner couples were recruited from communities in Hong Kong. They completed a pretest survey, a 14-day daily diary study, and a follow-up survey 1 year later. The Actor-Partner Interdependence Model was adopted to analyze the dyadic effects of sharing positive and negative work-related experiences on relationship satisfaction and personal well-being on the same day and 1 year later. In general, the sharing of both positive and negative work-related experiences had beneficial effects on the outcomes. Specifically, wives' sharing had more immediate effects on both partners' relational and personal well-being, whereas husbands' sharing had more long-term effects on the partner's personal well-being. The findings highlight the importance of work-related sharing in dual-earner couples. Practical implications are discussed.

Longing for grandparenthood: Its association with life satisfaction in late middle adulthood.

The present study applies the life-span theoretical concept of life longing (Sehnsucht) to grandparenthood as an important normative transition of middle and late adulthood that can be hoped for but not acted upon. A cross-sectional online study was conducted with N = 477 parents (73.5% women; age range: 40-81 years) whose adult children have not (yet) had offspring. Longing for grandparenthood was measured with a grandparenthood-specific adaptation of an established self-report questionnaire (Life Longing Questionnaire) and by employing a bifactor exploratory structural equation model (ESEM). As expected, strong expressions of longing for grandparenthood were associated with lower life satisfaction. Emotional support by the partner (here, perceiving the partner as understanding this Sehnsucht) offset this negative relationship (as did dispositional optimism, which an ancillary analysis revealed). By contrast, control over the longing fantasies did not help to attenuate the association between longing for grandparenthood and life satisfaction. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

How perceived maternal gatekeeping affects fathers: An 8-week study.

Maternal gatekeeping describes mothers' attempts to influence father involvement in child-rearing. While the effect of maternal gatekeeping on the father-child relationship has been explored, less is known about how fluctuations in the perception of maternal gatekeeping influences fathers' family outcomes and whether father's attachment might moderate these associations. Building on family systems theory, this study explores the within-person effect of negative maternal gatekeeping on father's weekly reports of romantic relationship quality and feelings of exclusion from the family and tests father attachment as a moderator of these associations. Two hundred seventy-seven Canadian and German fathers with children under the age of 6 took part in an 8-week online diary study. Data were analyzed using multilevel structural equation modeling. During weeks when fathers perceived more maternal gatekeeping than was typical, they reported lower positive romantic relationship quality, higher negative romantic relationship quality, and felt more excluded from the family system. Avoidant attachment moderated the within-person effect of perceived maternal gatekeeping on negative romantic relationship quality, such that within-person increases in perceived maternal gatekeeping were more strongly linked with higher than-average negative romantic relationship quality among more avoidant fathers. Our findings shed new light on the within-person effects of perceived maternal gatekeeping on fathers' feelings regarding the family system. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Moderately Hypofractionated Radio(chemo)therapy With Simultaneous Integrated Boost for Recurrent, Previously Irradiated, High-grade Glioma.

BACKGROUND/AIM: The therapy of recurrent, previously irradiated, high-grade gliomas is still a major interdisciplinary challenge, and the overall prognosis remains poor. Reirradiation has been established as a major component of the management of relapse, in addition to further debulking surgery and systemic options. Herein, we present a moderately hypofractionated reirradiation concept with simultaneous integrated boost for such recurrent, previously irradiated tumors. PATIENTS AND METHODS: From October 2019 to January 2021, 12 patients with recurrent malignant gliomas were re-irradiated. All patients had previously undergone surgery and irradiation with mostly normal fractions at the time of primary therapy. Radiotherapy of relapse was performed in all patients with 33 Gy, with 2.2 Gy single dose with a simultaneously integrated boost of 40.05 Gy with a single dose of 2.67 Gy in 15 fractions. Nine out of the 12 patients underwent debulking surgery before reirradiation, and seven patients received concurrent chemotherapy with temozolomide. The mean follow-up was 15.5 months. RESULTS: The median overall survival after recurrence was 9.3 months. The survival rate after 1 year was 33%. Toxicity during radiotherapy was low. In two patients, small areas of radionecrosis were observed at follow-up magnetic resonance imaging in the target volume; these patients were clinically asymptomatic. CONCLUSION: Moderate hypofractionation shortens the duration of radiotherapy and thereby improves accessibility for patients with limited mobility and prognosis, and achieves a respectable overall survival rate. Furthermore, the extent of late toxicity is also acceptable in these preirradiated patients.

Rare germline variants in POLE and POLD1 encoding the catalytic subunits of DNA polymerases ε and δ in glioma families.

Pathogenic germline variants in the DNA polymerase genes POLE and POLD1 cause polymerase proofreading-associated polyposis, a dominantly inherited disorder with increased risk of colorectal carcinomas and other tumors. POLE/POLD1 variants may result in high somatic mutation and neoantigen loads that confer susceptibility to immune checkpoint inhibitors (ICIs). To explore the role of POLE/POLD1 germline variants in glioma predisposition, whole-exome sequencing was applied to leukocyte DNA of glioma patients from 61 tumor families with at least one glioma case each. Rare heterozygous POLE/POLD1 missense variants predicted to be deleterious were identified in glioma patients from 10 (16%) families, co-segregating with the tumor phenotype in families with available DNA from several tumor patients. Glioblastoma patients carrying rare POLE variants had a mean overall survival of 21 months. Additionally, germline variants in POLD1, located at 19q13.33, were detected in 2/34 (6%) patients with 1p/19q-codeleted oligodendrogliomas, while POLE variants were identified in 2/4 (50%) glioblastoma patients with a spinal metastasis. In 13/15 (87%) gliomas from patients carrying POLE/POLD1 variants, features of defective polymerase proofreading, e.g. hypermutation, POLE/POLD1-associated mutational signatures, multinucleated cells, and increased intratumoral T cell response, were observed. In a CRISPR/Cas9-derived POLE-deficient LN-229 glioblastoma cell clone, a mutator phenotype and delayed S phase progression were detected compared to wildtype POLE cells. Our data provide evidence that rare POLE/POLD1 germline variants predispose to gliomas that may be susceptible to ICIs. Data compiled here suggest that glioma patients carrying POLE/POLD1 variants may be recognized by cutaneous manifestations, e.g. café-au-lait macules, and benefit from surveillance colonoscopy.

The Emesis Trial: Depressive Glioma Patients Are More Affected by Chemotherapy-Induced Nausea and Vomiting.

PURPOSE: Glioma patients face a limited life expectancy and at the same time, they suffer from afflicting symptoms and undesired effects of tumor treatment. Apart from bone marrow suppression, standard chemotherapy with temozolomide causes nausea, emesis and loss of appetite. In this pilot study, we investigated how chemotherapy-induced nausea and vomiting (CINV) affects the patients' levels of depression and their quality of life. METHODS: In this prospective observational multicentre study (n = 87), nausea, emesis and loss of appetite were evaluated with an expanded MASCC questionnaire, covering 10 days during the first and the second cycle of chemotherapy. Quality of life was assessed with the EORTC QLQ-C30 and BN 20 questionnaire and levels of depression with the PHQ-9 inventory before and after the first and second cycle of chemotherapy. RESULTS: CINV affected a minor part of patients. If present, it reached its maximum at day 3 and decreased to baseline level not before day 8. Levels of depression increased significantly after the first cycle of chemotherapy, but decreased during the further course of treatment. Patients with higher levels of depression were more severely affected by CINV and showed a lower quality of life through all time-points. CONCLUSION: We conclude that symptoms of depression should be perceived in advance and treated in order to avoid more severe side effects of tumor treatment. Additionally, in affected patients, delayed nausea was most prominent, pointing toward an activation of the NK1 receptor. We conclude that long acting antiemetics are necessary totreat temozolomide-induced nausea.

Applying different emotion regulation strategies while providing negative feedback: Introduction of a new laboratory protocol.

One aim of creating a new laboratory protocol was to investigate stress responses while being confronted with a work-related task, that is, having to provide negative feedback. It was central to the development of the scenario to make potential testosterone and cortisol responses measurable. The first part of the protocol comprises the introduction to the cover story, that is, being a member of the assessors' team as part of a larger assessment center program aiming to estimate the proficiency of students prior to their entry into professional life. Watching a video of one of the assessment center's candidates and having to assess his performance in a self-presentation task was introduced to personally involve participants in the feedback conversation they had to conduct with the same candidate later on. A second aim was to introduce an experimental manipulation in the form of instructions and brief tutorials regarding different emotion regulation strategies to apply. Participants were randomly assigned to one out of four conditions: expressive suppression (keeping a neutral expression); cognitive reappraisal (staying task-oriented and emotionally distanced); affect utilization (moving towards and using emotions); or control condition. Distinguishing these ways to regulate one's emotions enabled us to reveal differential hormonal stress responses: Applying either cognitive reappraisal or affect utilization strategies alleviated temporary testosterone declines compared with the other two conditions. This method article contains details regarding the procedure as well as the following documents in their original wording: • Introduction to the cover story (being a member of the assessors' team, observation of the attendant's self-presentation, assessment dimensions) • Slides and audio instructions regarding experimental conditions (how to regulate emotions) • Documents handed out to assist participants in conducting the feedback conversation.

Child-related bliss and couples' partnership satisfaction in the early parenthood period: A longitudinal dyadic perspective.

This research investigates the impact of parents' feelings of fulfillment and joy aroused by their infant and parenthood-referred to as child-related bliss-on their partnership satisfaction in the early period of parenthood between 6 and 24 months postpartum. In addition, the influence of partnership satisfaction during pregnancy and after childbirth on child-related bliss is investigated. Guided by family systems theory, we assumed both parents' child-related bliss to be positively associated with individual (i.e., spillover effects) as well as the spouse's partnership satisfaction (i.e., crossover effects). Longitudinal dyadic data from N = 135 heterosexual couples were analyzed using the actor-partner interdependence model, which takes interdependencies between couples into account. Taken as a set, the findings suggest that fathers' child-related and partnership-related perceptions are more closely linked than is the case for mothers. Fathers' child-related bliss 6 months postpartum positively influenced their partnership satisfaction at that time, and at 12 and 24 months postpartum. For mothers, in contrast, such spillover effects were not detected. Most importantly with respect to interdependencies between couples, the results indicate crossover effects from fathers to mothers, that is, fathers' child-related bliss positively contributed to mothers' partnership satisfaction in the postnatal period. In contrast, mothers' bliss did not influence fathers' partnership satisfaction. The study demonstrates that fathers' parental feelings of fulfillment and bliss contribute to their individual and to mothers' partnership satisfaction. This highlights gender-specific couple dynamics, that is, an influence of fathers' blissful child-related feelings on mothers' partnership satisfaction in the postnatal period. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Nail-biters and thrashing wins: Testosterone responses of football fans during World Cup matches.

Two main hypotheses have been formulated to explain short-term testosterone responses to competitions. The challenge hypothesis and the biosocial model of status make different predictions concerning the point of time, direction, and meaning of hormonal changes. This field study investigated whether testosterone reacts to experiences of challenge during the early stages of a competition or to experiences of status change as a consequence of the competition's outcome. Over a period of 28 days, approximately 2000 salivary testosterone samples were collected from 82 football fans (53% men), while they were watching the matches of their favorite national team during the 2014 World Cup. Conducting repeated measurements across seven competitive events (i.e., matches) and over the course of each match allowed us to split vicarious experiences during each competition into phases of challenge and phases of status change. For both sexes, the results revealed discriminable testosterone trajectories depending on whether the fans experienced highly competitive matches or quick victories. By use of a discontinuous change model, maximal testosterone increases were detected during experiences of challenge. In contrast, a return to pre-contest baseline testosterone levels was initiated as soon as a status gain became certain. Testosterone responsiveness was partly moderated by the subjective importance of the competitive event. Thus, this study provides evidence in favor of the challenge hypothesis and emphasizes the value of conducting high-resolution within-subject designs to further explain the adaptive meaning of androgen responses.

Going beyond work and family: A longitudinal study on the role of leisure in the work-life interplay.

Going beyond the relation of work and family, the present three-wave longitudinal study spanning one year assessed different forms of conflict and facilitation between leisure and the life domains work and family and their relation to subjective well-being. A sample of N = 277 employed men and women reported their perceived conflict and facilitation between leisure, work, and family and subjective well-being. Results suggest that leisure is a source of facilitation for work and family, and, at the same time, a major recipient of conflict from work and family. Moreover, leisure conflict was negatively correlated and leisure facilitation was positively associated with concurrent subjective well-being. Both conflict and facilitation between all three life domains remained highly stable over the course of one year. Only few and non-systematic lagged effects were found, indicating that the variance of the stability of the constructs and their relations over time leave little room for longitudinal predictions. Taken together, the study demonstrates that, similar to work-family relations, conflict and facilitation with the leisure domain are also associated with subjective well-being and remain highly stable over the course of a year in the lives of young and middle-aged adults.

Ecological performance of electrical consumer products: the influence of automation and information-based measures.

Being concerned with the environmental impact of electrical consumer products, this article examines possibilities of influencing ecological user performance through design features. Furthermore, it looks at the relationship of user characteristics and ecological performance. The impact of level of automation and type of control labelling on ecological user performance was examined in a lab-based experimental scenario with 36 users. In addition to performance indicators, a range of user variables (e.g., self-reported domestic behaviour, environmental knowledge and attitude) was measured to assess their influence on user behaviour. The results showed that low-level automation improved ecological performance whereas no such positive effect was observed for enhanced display-control labelling. Furthermore, the results suggested that the user's mental model of ecological performance was rather limited. No relationship was found between environmental knowledge, attitude and performance. The findings pointed at the strong prevalence of habits in the domestic domain. The implications of the results for designers of consumer products are discussed.

Designing low-complexity electrical consumer products for ecological use.

This study examined the environmental impact of low-complexity electrical consumer products during their use in a domestic context. In the experimental scenario, 48 users were asked to use a kettle under different conditions. On-product information (OPI), task instruction, and kettle design were employed as independent variables in a mixed multi-factorial design to examine their effects on different parameters of ecological performance (e.g., water and electricity consumption). Measures of user variables (environmental concern, knowledge, domestic habits, environmental control beliefs) were also taken to examine their relationship with performance parameters. The results revealed main effects of ecological task instruction, OPI and (partly) kettle design on ecological user behaviour. Habits, environmental concern and control beliefs were found to be related to performance parameters whereas knowledge was not. The implications of the results for product design are discussed against the background of a strong prevalence of habits and low ecological user motivation.