A Comparison of Mental Workload in Individuals with Transtibial and Transfemoral Lower Limb Loss during Dual-Task Walking under Varying Demand.

OBJECTIVES: This study aimed to evaluate the influence of lower limb loss (LL) on mental workload by assessing neurocognitive measures in individuals with unilateral transtibial (TT) versus those with transfemoral (TF) LL while dual-task walking under varying cognitive demand. METHODS: Electroencephalography (EEG) was recorded as participants performed a task of varying cognitive demand while being seated or walking (i.e., varying physical demand). RESULTS: The findings revealed both groups of participants (TT LL vs. TF LL) exhibited a similar EEG theta synchrony response as either the cognitive or the physical demand increased. Also, while individuals with TT LL maintained similar performance on the cognitive task during seated and walking conditions, those with TF LL exhibited performance decrements (slower response times) on the cognitive task during the walking in comparison to the seated conditions. Furthermore, those with TF LL neither exhibited regional differences in EEG low-alpha power while walking, nor EEG high-alpha desynchrony as a function of cognitive task difficulty while walking. This lack of alpha modulation coincided with no elevation of theta/alpha ratio power as a function of cognitive task difficulty in the TF LL group. CONCLUSIONS: This work suggests that both groups share some common but also different neurocognitive features during dual-task walking. Although all participants were able to recruit neural mechanisms critical for the maintenance of cognitive-motor performance under elevated cognitive or physical demands, the observed differences indicate that walking with a prosthesis, while concurrently performing a cognitive task, imposes additional cognitive demand in individuals with more proximal levels of amputation.

Biomechanical and neurocognitive performance outcomes of walking with transtibial limb loss while challenged by a concurrent task.

Individuals who have sustained loss of a lower limb may require adaptations in sensorimotor and control systems to effectively utilize a prosthesis, and the interaction of these systems during walking is not clearly understood for this patient population. The aim of this study was to concurrently evaluate temporospatial gait mechanics and cortical dynamics in a population with and without unilateral transtibial limb loss (TT). Utilizing motion capture and electroencephalography, these outcomes were simultaneously collected while participants with and without TT completed a concurrent task of varying difficulty (low- and high-demand) while seated and walking. All participants demonstrated a wider base of support and more stable gait pattern when walking and completing the high-demand concurrent task. The cortical dynamics were similarly modulated by the task demand for both groups, to include a decrease in the novelty-P3 component and increase in the frontal theta/parietal alpha ratio power when completing the high-demand task, although specific differences were also observed. These findings confirm and extend prior efforts indicating that dual-task walking can negatively affect walking mechanics and/or neurocognitive performance. However, there may be limited additional cognitive and/or biomechanical impact of utilizing a prosthesis in a stable, protected environment in TT who have acclimated to ambulating with a prosthesis. These results highlight the need for future work to evaluate interactions between these cognitive-motor control systems for individuals with more proximal levels of lower limb loss, and in more challenging (ecologically valid) environments.

Modulation of Vertical Ground Reaction Impulse With Real-Time Biofeedback: A Feasibility Study.

Given its apparent representation of cumulative (vs peak) loads, this feasibility study investigates vertical ground reaction impulse (vGRI) as a real-time biofeedback variable for gait training aimed at reducing lower limb loading. Fifteen uninjured participants (mean age = 27 y) completed 12 2-min trials, 1 at each combination of 4 walking speeds (1.0, 1.2, 1.4, and 1.6 m/s) and 3 targeted reductions in vGRI (5, 10, and 15%) of the assigned ("target") limb, with the latter specified relative to an initial baseline (no feedback) condition at each speed. The ability to achieve targeted reductions was assessed using step-by-step errors between measured and targeted vGRI. Mean (SD) errors were 5.2% (3.7%); these were larger with faster walking speeds but consistent across reduction targets. Secondarily, we evaluated the strategy used to modulate reductions (ie, stance time or peak vertical ground reaction force [vGRF]) and the resultant influences on knee joint loading (external knee adduction moment [EKAM]). On the targeted limb, stance times decreased (P < .001) with increasing reduction target; first and second peaks in vGRF were similar (P > .104) across all target conditions. While these alterations did not significantly reduce EKAM on the target limb, future work in patients with knee pathologies is warranted.

Mediolateral joint powers at the low back among persons with unilateral transfemoral amputation.

OBJECTIVE: To analyze mediolateral joint powers at the low back during gait among persons with and without unilateral transfemoral amputation to better understand the functional contributions of tissues in and around the low back to altered lateral trunk movements in this population. DESIGN: Retrospective analysis of biomechanical gait data. SETTING: Gait laboratory. PARTICIPANTS: Twenty persons with unilateral transfemoral amputation and 20 uninjured controls (N=40). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Net joint powers, and total generation (+) and absorption (-) energies, at the low back (L5/S1 spinal level) were analyzed in the frontal plane using inverse dynamics analyses on over-ground gait data collected at self-selected walking speeds (∼1.3m/s). RESULTS: Compared with uninjured controls, 4 distinctly larger positive phases of mediolateral joint power at L5/S1 were evident in persons with transfemoral amputation, occurring before and after each heel strike. Total generation energies throughout the gait cycle were also larger (P<.001) among persons with transfemoral amputation (4.8±1.4J) than among uninjured controls (1.3±0.7J). CONCLUSIONS: Larger positive phases of joint power at L5/S1 in the frontal plane support previous suggestions that persons with transfemoral amputation use a more active mediolateral trunk movement strategy, although such an active trunk movement strategy with transfemoral amputation may contribute to higher metabolic energy expenditures and low back pain risk.

Does a microprocessor-controlled prosthetic knee affect stair ascent strategies in persons with transfemoral amputation?

BACKGROUND: Stair ascent can be difficult for individuals with transfemoral amputation because of the loss of knee function. Most individuals with transfemoral amputation use either a step-to-step (nonreciprocal, advancing one stair at a time) or skip-step strategy (nonreciprocal, advancing two stairs at a time), rather than a step-over-step (reciprocal) strategy, because step-to-step and skip-step allow the leading intact limb to do the majority of work. A new microprocessor-controlled knee (Ottobock X2(®)) uses flexion/extension resistance to allow step-over-step stair ascent. QUESTIONS/PURPOSES: We compared self-selected stair ascent strategies between conventional and X2(®) prosthetic knees, examined between-limb differences, and differentiated stair ascent mechanics between X2(®) users and individuals without amputation. We also determined which factors are associated with differences in knee position during initial contact and swing within X2(®) users. METHODS: Fourteen individuals with transfemoral amputation participated in stair ascent sessions while using conventional and X2(®) knees. Ten individuals without amputation also completed a stair ascent session. Lower-extremity stair ascent joint angles, moment, and powers and ground reaction forces were calculated using inverse dynamics during self-selected strategy and cadence and controlled cadence using a step-over-step strategy. RESULTS: One individual with amputation self-selected a step-over-step strategy while using a conventional knee, while 10 individuals self-selected a step-over-step strategy while using X2(®) knees. Individuals with amputation used greater prosthetic knee flexion during initial contact (32.5°, p = 0.003) and swing (68.2°, p = 0.001) with higher intersubject variability while using X2(®) knees compared to conventional knees (initial contact: 1.6°, swing: 6.2°). The increased prosthetic knee flexion while using X2(®) knees normalized knee kinematics to individuals without amputation during swing (88.4°, p = 0.179) but not during initial contact (65.7°, p = 0.002). Prosthetic knee flexion during initial contact and swing were positively correlated with prosthetic limb hip power during pull-up (r = 0.641, p = 0.046) and push-up/early swing (r = 0.993, p < 0.001), respectively. CONCLUSIONS: Participants with transfemoral amputation were more likely to self-select a step-over-step strategy similar to individuals without amputation while using X2(®) knees than conventional prostheses. Additionally, the increased prosthetic knee flexion used with X2(®) knees placed large power demands on the hip during pull-up and push-up/early swing. A modified strategy that uses less knee flexion can be used to allow step-over-step ascent in individuals with less hip strength.

Transfemoral amputations: is there an effect of residual limb length and orientation on energy expenditure?

BACKGROUND: Energy cost of ambulation has been evaluated using a variety of measures. With aberrant motions resulting from compensatory strategies, persons with transfemoral amputations generally exhibit a larger center of mass excursion and an increased energy cost. However, few studies have analyzed the effect of residual femur length and orientation or energy cost of ambulation. QUESTIONS/PURPOSES: The purpose of this study was to compare residual limb length and orientation with energy efficiency in patients with transfemoral amputation. We hypothesized that patients with shorter residual limbs and/or more abnormal residual femur alignment would have higher energy expenditure cost and greater center of mass movement than those with longer residual limbs resulting from lacking musculature, shorter and/or misoriented lever arms, and greater effort required to ambulate through use of compensatory movements. METHODS: Twenty-six adults with acute, trauma-related unilateral transfemoral amputations underwent gait and metabolic analysis testing. Patients were separated into groups for analysis based on residual limb length and residual femoral angle. RESULTS: Cohorts with longer residual limbs walked faster than those with shorter residual limbs (self-selected walking velocity 1.28 m/s versus 1.11 m/s, measured effect size = 1.08; 95% confidence interval = short 1.10-1.12, long 1.26-1.30; p = 0.04). However, there were no differences found with the numbers available between the compared cohorts regardless of limb length or orientation in regard to O2 cost or other metabolic variables, including the center of mass motion. CONCLUSIONS: Those with longer residual limbs after transfemoral amputation chose a faster self-selected walking velocity, mirroring previous studies; however, metabolic energy and center of mass metrics did not demonstrate a difference in determining whether energy expenditure is affected by length or orientation of the residual limb after transfemoral amputation. These factors may therefore have less effect on transfemoral amputee gait efficiency and energy requirements than previously thought.

Does intact limb loading differ in servicemembers with traumatic lower limb loss?

BACKGROUND: The initiation and progression of knee and hip arthritis have been related to limb loading during ambulation. Although altered gait mechanics with unilateral lower limb loss often result in larger and more prolonged forces through the intact limb, how these forces differ with traumatic limb loss and duration of ambulation have not been well described. QUESTIONS/PURPOSES: The purpose of this study was to determine whether biomechanical variables of joint and limb loading (external adduction moments, vertical ground reaction force loading rates, and impulses) are larger in the intact limb of servicemembers with versus without unilateral lower limb loss and whether intact limb loading differs between shorter (≤ 6 months) versus longer (≥ 2 years) durations of ambulation with a prosthesis. METHODS: A retrospective review was conducted of all clinical and research gait evaluations performed in the biomechanics laboratory at Walter Reed Army Medical Center and Walter Reed National Military Medical Center between January 2008 and December 2012. Biomechanical data meeting all inclusion and exclusion criteria were obtained for 32 individuals with unilateral transtibial limb loss, 49 with unilateral transfemoral limb loss, and 28 without limb loss. Individuals with unilateral lower limb loss were separated by their experience ambulating with a prosthesis at the time of the gait collection, ≤ 6 months or ≥ 2 years, to determine the effect of duration of ambulation with a prosthesis. RESULTS: Intact limb mean and peak vertical ground reaction force loading rates (median [range; 95% confidence interval]) were larger for transtibial subjects with ≤ 6 months of experience ambulating with a prosthesis versus control subjects (mean: 12.13 body weight [BW]/s [4.45-16.79; 10.18-12.81] versus 9.03 BW/s [4.64-14.47; 8.26-9.74]; effect size [ES] = 0.40; p = 0.003; and peak: 17.23 BW/s [6.58-25.25; 15.46-19.01] versus 13.60 BW/s [9.82-19.51; 12.98-15.05]; ES = 0.43; p = 0.001), respectively. Intact limb mean and peak vertical ground reaction force loading rates were also larger in subjects with transfemoral limb loss with ≤ 6 months and ≥ 2 years of experience ambulating with a prosthesis versus control subjects (mean: 12.67 BW/s [5.88-18.15; 11.06-14.47] and 12.59 BW/s [8.08-17.39; 11.83-13.68] versus 9.03 BW/s [4.64-14.47; 8.26-9.74]; ES ≥ 0.53; p < 0.001; peak: 19.82 BW/s [11.93-29.43; 18.35-23.05] and 21.33 BW/s [16.68-36.69; 20.66-24.26] versus 13.60 BW/s [9.82-19.51; 12.98-15.05]; ES ≥ 0.68; p < 0.001, respectively). Similarly, intact limb vertical ground reaction force impulses (0.63 BW·s [0.53-0.81; 0.67-0.69] and 0.62 BW·s [0.55-0.74; 0.60-0.63] versus 0.57 BW·s [0.50-0.66; 0.55-0.58]; ES ≥ 0.53, p < 0.001) were also larger among both groups of transfemoral subjects versus control subjects, respectively. Limb loading variables were not statistically different between times ambulating with a prosthesis within groups with transtibial or transfemoral limb loss. CONCLUSIONS: Larger intact limb loading in individuals with traumatic transtibial loss were only noted early in the rehabilitation process, but these variables were present early and late in the rehabilitation process for those with transfemoral limb loss. Such evidence suggests an increased risk for early onset and progression of arthritis in the intact limb, especially in those with transfemoral limb loss. CLINICAL RELEVANCE: Interventions should focus on correcting modifiable gait mechanics associated with arthritis, particularly among individuals with transfemoral limb loss, to potentially mitigate the development and progression in this population.

Amputee locomotion: determining the inertial properties of running-specific prostheses.

OBJECTIVES: (1) To test the validity of a trifilar pendulum in estimating moments of inertia (MOIs) for running-specific prostheses (RSPs), (2) to measure inertial properties (mass, center of mass [CM] position, and MOIs) for 4 RSPs, (3) to verify the influence of the stiffness on the inertial properties of RSPs, and (4) to develop a predictive equation to estimate RSP CM positions. DESIGN: An aluminum block with known MOIs was used for verifying the accuracy of the trifilar pendulum MOI measurements. MOI errors were investigated by systematically misaligning the block and pendulum principal axes across a range of 1 to 10cm. Mass, CM position, and MOI were tested across 4 RSP designs with 3 stiffness categories each. SETTING: University biomechanics laboratory. SPECIMENS: Four different RSP designs and 3 stiffness categories per design were examined. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: MOI errors from known values and principal axis misalignments between RSPs and pendulum; mass, CM positions, and RSP principal axis MOIs; and predictive equation CM position errors. RESULTS: The trifilar pendulum estimated MOIs within -6.21×10(-5)kg/m(2) (≤1% error) for a block with known MOIs. Misalignments of 1 to 5cm between the RSPs' and pendulum's CM yielded errors from .00002 to .00113 kg/m(2) (0.3%-59.2%). Each RSP's inertial properties are presented. MOIs about any axis varied <.004kg/m(2) across stiffness categories; MOIs differed up to .013kg/m(2) between different designs. The predictive CM equation erred between .010 and .028m when using average input values across an RSP design. CONCLUSIONS: Trifilar pendulums can accurately measure RSP MOI. The RSP inertial properties differed slightly across stiffness categories within each design, but differed more substantially across different RSP designs. Using a predictive equation to estimate RSP CM positions can provide adequate data, but directly measuring CM positions is preferable.

Advanced technologies for intuitive control and sensation of prosthetics.

The Department of Defense, Department of Veterans Affairs and National Institutes of Health have invested significantly in advancing prosthetic technologies over the past 25 years, with the overall intent to improve the function, participation and quality of life of Service Members, Veterans, and all United States Citizens living with limb loss. These investments have contributed to substantial advancements in the control and sensory perception of prosthetic devices over the past decade. While control of motorized prosthetic devices through the use of electromyography has been widely available since the 1980s, this technology is not intuitive. Additionally, these systems do not provide stimulation for sensory perception. Recent research has made significant advancement not only in the intuitive use of electromyography for control but also in the ability to provide relevant meaningful perceptions through various stimulation approaches. While much of this previous work has traditionally focused on those with upper extremity amputation, new developments include advanced bidirectional neuroprostheses that are applicable to both the upper and lower limb amputation. The goal of this review is to examine the state-of-the-science in the areas of intuitive control and sensation of prosthetic devices and to discuss areas of exploration for the future. Current research and development efforts in external systems, implanted systems, surgical approaches, and regenerative approaches will be explored.

Medial knee joint contact force in the intact limb during walking in recently ambulatory service members with unilateral limb loss: a cross-sectional study.

BACKGROUND: Individuals with unilateral lower limb amputation have a high risk of developing knee osteoarthritis (OA) in their intact limb as they age. This risk may be related to joint loading experienced earlier in life. We hypothesized that loading during walking would be greater in the intact limb of young US military service members with limb loss than in controls with no limb loss. METHODS: Cross-sectional instrumented gait analysis at self-selected walking speeds with a limb loss group (N = 10, age 27 ± 5 years, 170 ± 36 days since last surgery) including five service members with transtibial limb loss and five with transfemoral limb loss, all walking independently with their first prosthesis for approximately two months. Controls (N = 10, age 30 ± 4 years) were service members with no overt demographical risk factors for knee OA. 3D inverse dynamics modeling was performed to calculate joint moments and medial knee joint contact forces (JCF) were calculated using a reduction-based musculoskeletal modeling method and expressed relative to body weight (BW). RESULTS: Peak JCF and maximum JCF loading rate were significantly greater in limb loss (184% BW, 2,469% BW/s) vs. controls (157% BW, 1,985% BW/s), with large effect sizes. Results were robust to probabilistic perturbations to the knee model parameters. DISCUSSION: Assuming these data are reflective of joint loading experienced in daily life, they support a "mechanical overloading" hypothesis for the risk of developing knee OA in the intact limb of limb loss subjects. Examination of the evolution of gait mechanics, joint loading, and joint health over time, as well as interventions to reduce load or strengthen the ability of the joint to withstand loads, is warranted.

Locomotor adaptability in persons with unilateral transtibial amputation.

BACKGROUND: Locomotor adaptation enables walkers to modify strategies when faced with challenging walking conditions. While a variety of neurological injuries can impair locomotor adaptability, the effect of a lower extremity amputation on adaptability is poorly understood. OBJECTIVE: Determine if locomotor adaptability is impaired in persons with unilateral transtibial amputation (TTA). METHODS: The locomotor adaptability of 10 persons with a TTA and 8 persons without an amputation was tested while walking on a split-belt treadmill with the parallel belts running at the same (tied) or different (split) speeds. In the split condition, participants walked for 15 minutes with the respective belts moving at 0.5 m/s and 1.5 m/s. Temporal spatial symmetry measures were used to evaluate reactive accommodations to the perturbation, and the adaptive/de-adaptive response. RESULTS: Persons with TTA and the reference group of persons without amputation both demonstrated highly symmetric walking at baseline. During the split adaptation and tied post-adaptation walking both groups responded with the expected reactive accommodations. Likewise, adaptive and de-adaptive responses were observed. The magnitude and rate of change in the adaptive and de-adaptive responses were similar for persons with TTA and those without an amputation. Furthermore, adaptability was no different based on belt assignment for the prosthetic limb during split adaptation walking. CONCLUSIONS: Reactive changes and locomotor adaptation in response to a challenging and novel walking condition were similar in persons with TTA to those without an amputation. Results suggest persons with TTA have the capacity to modify locomotor strategies to meet the demands of most walking conditions despite challenges imposed by an amputation and use of a prosthetic limb.

Gait and Functional Outcomes for Young, Active Males With Traumatic Unilateral Transfemoral Limb Loss.

OBJECTIVE: Altered body structures that occur with the loss of a lower limb can impact mobility and quality of life. Specifically, biomechanical changes that result from wearing a prosthesis have been associated with an increased risk of falls or joint degeneration, as well as increased energy demands. While previous studies describing these outcomes are typically limited by number of outcome measures and/or small, diverse patient groups, recent military conflicts present a unique opportunity to collect outcomes from a relatively homogenous, active patient population with limb loss. Thus, the objective of this study is to provide reference outcome measures on the basis of a large, relatively homogenous cohort of military personnel with transfemoral limb loss. METHODS: A retrospective review of biomechanical, physiological, functional, and subjective measures was completed for 67 male servicemembers who sustained an injury resulting in traumatic, transfemoral limb loss during recent conflicts. These individuals represent a defined cohort, capable of exhibiting improved clinical outcomes resulting from demographic characteristics and extensive rehabilitation. Biomechanical and physiological outcome measures for 76 uninjured male servicemembers are also provided to serve as normative reference for full return to function. Select biomechanical and physiological outcomes related to stability, overuse, and efficiency are discussed in the text, on the basis of relevance to clinical gait assessment, in addition to functional and subjective measures. RESULTS: In general, individuals with transfemoral limb loss exhibit decreased stability relative to uninjured individuals, noted by larger peak trunk velocity and step width variability; increased risk of low back and knee joint pain and/or degeneration, noted by larger trunk lateral flexion and bending moments, as well as larger vertical ground reaction force (vGRF) loading rates and impulses, respectively; and decreased efficiency during gait, noted by larger oxygen costs and leading limb mechanical work. CONCLUSION: Although the comprehensive set of measures presented here indicates overall reductions in biomechanical and functional performance with transfemoral limb loss compared to uninjured individuals, these reductions were relatively smaller than existing evidence among populations that are more diverse in age and activity level. Therefore, this data set may be used as benchmarks for young, active individuals with transfemoral limb loss, to assist with setting clinical goals, and to aid in the evaluation of new treatment techniques or interventions. These measures will also be particularly important for subsequent evaluations and longitudinal follow-ups to determine the longer-term impact of transfemoral limb loss on this cohort.

Performance of conventional and X2® prosthetic knees during slope descent.

BACKGROUND: Individuals with transfemoral amputation often have difficulty descending sloped surfaces due to increased lower extremity range of motion and torque requirements. The X2®, a new microprocessor-controlled prosthetic knee, claims to improve gait over sloped terrain. The aim of this study was to evaluate how experienced prosthesis users descended a sloped surface using the X2®, compared to a conventional knee, either mechanical (MECH) or microprocessor (MP). METHODS: Descent technique and biomechanics were assessed in 21 service members with unilateral transfemoral amputation as they descended an instrumented 10° slope at a self-selected walking velocity. FINDINGS: Use of the X2® in the MECH group resulted in greater hill assessment scores (8.5 to 11.0, P=0.026), due primarily to decreased reliance on handrail use. The use of the X2® in the MP group increased prosthetic knee flexion to a median of 6.4° at initial contact (P=0.002) and 73.7° in swing (P=0.005), contributing to longer prosthetic limb steps (P=0.024) and increased self-selected velocity (P=0.041). Additionally, the use of the X2® in the MP group increased prosthetic limb impact peaks (11.6N/kg, P=0.004), improving impact peak symmetry to -1.3% (P=0.004). INTERPRETATION: Decreased reliance on handrail use as MECH users descended in the X2® indicate improved function and perhaps greater confidence in the device. Additional biomechanical improvements for existing MP users suggest potential longer-term benefits with regard to intact limb health and overuse injuries.

Persons with unilateral transfemoral amputation experience larger spinal loads during level-ground walking compared to able-bodied individuals.

BACKGROUND: Persons with lower limb amputation walk with increased and asymmetric trunk motion; a characteristic that is likely to impose distinct demands on trunk muscles to maintain equilibrium and stability of the spine. However, trunk muscle responses to such changes in net mechanical demands, and the resultant effects on spinal loads, have yet to be determined in this population. METHODS: Building on a prior study, trunk and pelvic kinematics collected during level-ground walking from 40 males (20 with unilateral transfemoral amputation and 20 matched controls) were used as inputs to a kinematics-driven, nonlinear finite element model of the lower back to estimate forces in 10 global (attached to thorax) and 46 local (attached to lumbar vertebrae) trunk muscles, as well as compression, lateral, and antero-posterior shear forces at all spinal levels. FINDINGS: Trunk muscle force and spinal load maxima corresponded with heel strike and toe off events, and among persons with amputation, were respectively 10-40% and 17-95% larger during intact vs. prosthetic stance, as well as 6-80% and 26-60% larger during intact stance relative to controls. INTERPRETATION: During gait, larger spinal loads with transfemoral amputation appear to be the result of a complex pattern of trunk muscle recruitment, particularly involving co-activation of antagonistic muscles during intact limb stance; a period when these individuals are confident and likely to use the trunk to assist with forward progression. Given the repetitive nature of walking, repeated exposure to such elevated loading likely increases the risk for low back pain in this population.

Functional Outcomes of Service Members With Bilateral Transfemoral and Knee Disarticulation Amputations Resulting From Trauma.

As longitudinal studies for those with bilateral transfemoral amputation (BTFA) or knee disarticulation (KD) are lacking, it is important to quantify performance measures during rehabilitation in an effort to determine reasonable expectations and trends that may influence the rehabilitation process. At initial evaluation (date of first independent ambulation) and follow up (median 135 [range = 47-300] days later), 10 participants with BTFA/KD completed 6 minute walk testing and Activity Specific Balance Confidence and Lower Extremity Functional Scale questionnaires. Of these, six participants also completed stair ambulation; ascent time and stair assessment index (SAI) scores were calculated. Patients utilized their prescribed prostheses at each visit. Participants were able to cover a significantly greater distance (135.3 [70.1] m) in 6 minutes at the follow-up visit (*p = 0.005). The change in SAI scores for stair ascent and descent was not statistically significant (p = 0.247). Stair ambulation confidence scores were significantly greater at the final visit (*p = 0.034). Stair negotiation appears to plateau early; however, confidence builds despite absence of functional gains over time. Service members with BTFAs/KDs are able to achieve functional community ambulation skills. Thus, this investigation suggests that clinicians can realign rehabilitation paradigms to shift focus towards community distance ambulation once safe stair ascent and descent is achieved.

Persons with unilateral transfemoral amputation have altered lumbosacral kinetics during sitting and standing movements.

Increases in spinal loading have been related to altered movements of the lower back during gait among persons with lower limb amputation, movements which are self-perceived by these individuals as contributing factors in the development of low back pain. However, the relationships between altered trunk kinematics and associated changes in lumbosacral kinetics during sit-to-stand and stand-to-sit movements in this population have not yet been assessed. Three-dimensional lumbosacral kinetics (joint moments and powers) were compared between 9 persons with unilateral transfemoral amputation (wearing both a powered and passive knee device), and 9 uninjured controls, performing five consecutive sit-to-stand and stand-to-sit movements. During sit-to-stand movements, lumbosacral joint moments and powers were significantly larger among persons with transfemoral amputation relative to uninjured controls. During stand-to-sit movements, lumbosacral joint moments and powers were also significantly larger among persons with transfemoral amputation relative to uninjured controls, with the exception of sagittal joint powers. Minimal differences in kinetic measures were noted between the powered and passive knee devices among persons with transfemoral amputation across all conditions. Altered lumbosacral kinetics during sitting and standing movements, important activities of daily living, may play a biomechanical role in the onset and/or recurrence of low back pain or injury among persons with lower-limb amputation.

Whole-body vibration during manual wheelchair propulsion with selected seat cushions and back supports.

Although the exposure to whole-body vibrations (WBV) has been shown to be detrimental to seated humans, the effects of wheelchairs and seating systems on the transmission of vibration to an individual have not been thoroughly examined. The purpose of this study was to determine if the selected wheelchair seat cushions and back supports minimize the transmission of vibrations. Thirty-two wheelchair users traversed an activities of daily living course three times using 16 randomly selected seating systems as well as their own. Vibrations were measured using triaxial accelerometers at the seat and participant's head. The weighted fore-to-aft (Tx), vertical (Tz), and resultant (Tr) transmissibility based on the vibrational-dose-value (VDV) were used to determine if differences existed among the four seat cushions and back supports. The obstacles that seem to have the largest effect on the transmission of WBV are the single event shocks and the repeated event shocks. Comparisons between the individuals own seating system and the tested seating systems suggest that the individuals are not using the most appropriate seating system in terms of the reduction of vibration transmission.

Using the absorbed power method to evaluate effectiveness of vibration absorption of selected seat cushions during manual wheelchair propulsion.

Although wheelchair users are frequently subjected to oscillatory and shock vibrations, little research has been conducted to assess the whole-body vibration exposure of wheelchair users. The purpose of this study was to determine if selected wheelchair cushions alter potentially harmful whole-body vibrations transferred to wheelchair users. Thirty-two participants, who use wheelchairs as their primary mode of mobility, contributed to this study. Four of the most commonly prescribed wheelchair cushions were selected. Participants were asked to propel their wheelchair over a simulated activities of daily living (ADL) course while acceleration and force data were recorded. A repeated measures ANOVA showed no significant differences between the different cushions for the total averaged absorbed power (p = 0.190), the 50 mm curb drop (p = 0.234), or the rumble strip (p = 0.143). A repeated measure ANOVA for the peak curb drop absorbed power revealed a significant difference in the cushions (p = 0.043). The cushions that were most effective in this testing appear to be the Invacare Pindot and the Varilite Solo. Not only did those cushions appear to have the lowest values much of the time but also they did not display the highest values. When comparing results from a similar study, absorbed power appears to be as effective in determining vibration effects in the time domain as the methods in the ISO 2631 Standard.

Three-dimensional joint reaction forces and moments at the low back during over-ground walking in persons with unilateral lower-extremity amputation.

BACKGROUND: Abnormal mechanics of locomotion following lower-extremity amputation are associated with increases in trunk motion, which in turn may alter loads at the low back due to changes in inertial and gravitational demands on the spine and surrounding trunk musculature. METHODS: Over-ground gait data were retrospectively compiled from two groups walking at similar self-selected speeds (~1.35m/s): 40 males with unilateral lower-extremity amputation (20 transtibial, 20 transfemoral) and 20 able-bodied male controls. Three-dimensional joint reaction forces and moments at the low back (L5/S1 spinal level) were calculated using top-down and bottom-up approaches. Peak values and the timings of these were determined and compared between and within (bilaterally) groups, and secondarily between approaches. FINDINGS: Peak laterally-directed joint reaction forces and lateral bend moments increased with increasing level of amputation, and were respectively 83% and 41% larger in prosthetic vs. intact stance among persons with transfemoral amputation. Peak anteriorly-directed reaction forces and extension moments were 31% and 55% larger, respectively, among persons with transtibial amputation compared to controls. Peak vertical reaction forces and axial twist moments were similar between and within groups. Peak joint reaction forces and moments were larger (3-14%), and the respective timing of these sooner (11-62ms), from the bottom-up vs. top-down approach. INTERPRETATION: Increased and asymmetric peak reaction forces and moments at the low back among persons with unilateral lower-extremity amputation, particularly in the frontal plane, suggest potential mechanistic pathways through which repeated exposure to altered trunk motion and spinal loading may contribute to low-back injury risk among persons with lower-extremity amputation.

Kinematic analysis of males with transtibial amputation carrying military loads.

The biomechanical responses to load carriage, a common task for dismounted troops, have been well studied in nondisabled individuals. However, with recent shifts in the rehabilitation and retention process of injured servicemembers, there remains a substantial need for understanding these responses in persons with lower-limb amputations. Temporal-spatial and kinematic gait parameters were analyzed among 10 male servicemembers with unilateral transtibial amputation (TTA) and 10 uninjured male controls. Participants completed six treadmill walking trials in all combinations of two speeds (1.34 and 1.52 m/s) and three loads (none, 21.8, and 32.7 kg). Persons with TTA exhibited biomechanical compensations to carried loads that are comparable to those observed in uninjured individuals. However, several distinct gait changes appear to be unique to those with TTA, notably, increased dorsiflexion (deformation) of the prosthetic foot/ankle, less stance knee flexion on the prosthetic limb, and altered trunk forward lean/excursion. Such evidence supports the need for future work to assess the risk for overuse injuries with carried loads in this population in addition to guiding the development of adaptive prosthetic feet/components to meet the needs of redeployed servicemembers or veterans/civilians in physically demanding occupations.